Metabolic and Immunologic Effects of Meditation

冥想的代谢和免疫作用

• 批准号: 8094377
• 负责人: Frederick M Hecht
• 金额: $ 115.81万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8094377
• 关键词: Abdomen; Accounting; Address; Affect; Antibody Formation; Arousal; Autonomic nervous system; Awareness; Behavior Therapy; Behavioral; Biological; Body Weight decreased; Cholesterol; Clinical Research; Clinical Trials; Complementary and alternative medicine; Cues; Data; Deposition; Desire for food; Diet; Dyslipidemias; Eating; Eating Behavior; Elements; Epidemic; Exercise; Fatty acid glycerol esters; Foundations; Goals; Grant; Group Meetings; HIV Infections; Health; Hormones; Hunger; Hydrocortisone; Hypertension; Immune response; Immune system; Immunologics; Indium; Individual; Influenza vaccination; Insulin Resistance; Integrative Medicine; Intervention; Investigation; Lead; Link; Location; Maintenance; Mediating; Mediation; Meditation; Metabolic; Metabolic syndrome; Mind-Body Intervention; Mind-Body Method; Modeling; Moderate Exercise; Moods; National Center for Complementary and Alternative Medicine; Neurobiology; Obesity; Outcome; Participant; Pathway interactions; Pattern; Perception; Peripheral; Phase; Process; Public Health; Randomized; Randomized Controlled Clinical Trials; Randomized Controlled Trials; Research; Satiation; Stress; Structure; Testing; Time; Training; Vaccines; Walking; abdominal fat; base; biological adaptation to stress; craving; diet and exercise; good diet; hypothalamic-pituitary-adrenal axis; immune function; improved; influenza virus vaccine; insulin sensitivity; meetings; mindfulness; mindfulness meditation; mindfulness-based stress reduction; programs; psychologic; response; weight loss intervention; weight maintenance

DESCRIPTION (provided by applicant): Obesity is epidemic and is one of our most serious public health problems. Many of obesity's unfavorable health effects are more strongly related to central (abdominal and upper trunk) adiposity than to peripheral adiposity. Central adiposity is closely linked to other components of metabolic syndrome: increased cholesterol, hypertension, and insulin resistance. Adverse stress hormone patterns appear to favor central fat deposition. In addition, adverse stress responses may drive eating patterns that lead to obesity. The overall goal of this project is to test whether a meditation based intervention that can shift stress hormone patterns, when added to a diet and exercise program, improves fat distribution and enhances weight loss and maintenance of weight loss. We have developed an intervention that applies mindfulness meditation practices to obesity and metabolic syndrome, Craving and Lifestyle Modification through Mindfulness (CALMM). The intervention draws on Mindfulness Based Stress Reduction and Mindfulness Based Eating Awareness Training. CALMM aims to decrease adverse stress responses, improve sensitivity to hunger satiety cues, and develop mindful eating practices. Initial data suggests that CALMM supports gradual weight loss, improvements in stress cortisol responses, and decreased abdominal fat. The diet component of CALMM+ aims for a modest calorie reduction (typically 500 Kcal/day) and focuses on healthy diet choices that facilitate caloric reduction. The exercise component of CALMM+ focuses on moderate exercise, primarily through increased daily walking as well as through structured exercise time. Both the diet and exercise components of CALMM+ incorporate mindfulness, e.g. mindful walking exercise and mindful eating. We have also developed a program, Diet-Ex, that uses the diet and exercise components from CALMM+, without the integration of mindfulness practices into diet and exercise. In this project, 200 participants will be randomized in a 1:1 ratio to CALMM+ or Diet-Ex. Groups will meet for 16 weekly sessions, then monthly during a 4 month maintenance phase. We will compare the effects of each intervention on weight loss and its maintenance, fat distribution, insulin sensitivity, and perceived stress and mood over an 18 month period. We hypothesize that the CALMM+ group will achieve greater improvements in fat distribution and maintain the most weight loss over 18 months. The results of the study will provide important new information about whether a mind-body intervention targeted to reduce adverse stress reactions and improve awareness of eating behaviors is useful in treating obesity and altering features of the metabolic syndrome.

描述（由申请人提供）：肥胖是流行病，是我们最严重的公共卫生问题之一。肥胖的许多不利的健康影响与中央（腹部和上部躯干）肥胖更为密切，而不是与外围肥胖。中央肥胖与代谢综合征的其他成分紧密相关：胆固醇，高血压和胰岛素抵抗增加。不良应力激素模式似乎有利于中心脂肪沉积。此外，不良压力反应可能会促进导致肥胖症的饮食模式。该项目的总体目标是测试基于冥想的干预措施，该干预措施是否可以改变饮食和运动计划，改善脂肪分布并增强体重减轻并维持体重减轻。我们已经开发了一种干预措施，将正念冥想实践应用于肥胖和代谢综合征，渴望和通过正念修改（Calmm）的生活方式修改。干预依赖于基于正念的压力减轻和基于正念的饮食意识训练。 Calmm的目标是减少不利的压力反应，提高对饥饿线索的敏感性，并发展正念饮食习惯。最初的数据表明，CALMM支持逐渐体重减轻，压力皮质醇反应的改善以及减少腹部脂肪。 Calmm+的饮食成分旨在减少卡路里（通常为500 kcal/day），并着重于促进降低热量的健康饮食选择。 Calmm+的运动成分集中在适度的运动上，主要是通过增加日常行走以及结构化的运动时间。 Calmm+的饮食和运动成分都融合了正念，例如谨慎的步行锻炼和正念饮食。我们还开发了一个饮食 - EX的计划，该计划使用Calmm+的饮食和运动组成部分，而无需将正念实践整合到饮食和运动中。在这个项目中，将有200名参与者与Calmm+或Diet-EX以1：1的比例随机分配。小组将开会16个每周一次，然后在4个月的维护阶段每月开会。我们将比较每种干预对体重减轻及其维持，脂肪分布，胰岛素敏感性以及在18个月内的压力和情绪的影响。我们假设Calmm+组将在脂肪分布方面取得更大的改善，并在18个月内保持最大的体重减轻。该研究的结果将提供有关旨在减少不良压力反应和提高对饮食行为的意识的心身干预措施的重要新信息，可用于治疗肥胖和改变代谢综合征的特征。