FASEB SRC on Skeletal Muscle Satellite and Stem Cells

FASEB SRC 关于骨骼肌卫星和干细胞

基本信息

批准号：
8397854
负责人：
Grace K Pavlath
金额：
$ 2.8万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8397854
关键词：
Activities of Daily Living Address Adult Aging American Basal lamina Basic Science Biology Cell Communication Cells Cellular biology Clinical Sciences Data Development Disease Environment Epigenetic Process Exercise Fertilization Future Growth Hypertrophy Individual Injury Investigation Italy Lead Location Molecular Muscle Muscle satellite cell Muscular Atrophy Natural regeneration Participant Patients Population Post-Transcriptional Regulation Process Proliferating Regenerative Medicine Research Research Personnel Role Science Skeletal Muscle Skeletal Muscle Satellite Cells Societies Stem cells Stimulus Therapeutic Time Tissues Trauma abstracting adult stem cell age effect age related insight interest meetings multidisciplinary muscle degeneration muscle regeneration posters programs regenerative response satellite cell self-renewal stem stem cell biology stem cell population success symposium therapeutic development

项目摘要

DESCRIPTION (provided by applicant): This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, Skeletal Muscle Satellite and Stem cells, that will be held on August 12-17, 2012 in Lucca, Italy. We expect approximately 185 attendees from around the world. The overall objective of this meeting is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cell and progenitor cell populations (such as satellite cells) and their role in development, regeneration, hypertrophy, aging and myopathic states. This will be the 7th conference focused on satellite cells/stem cells and muscle regeneration. The increased participation from the first to the sixth meetings has demonstrated the need for a conference dedicated to satellite and stem cells. It is clear from the successes of the previous six meetings that this topic is of high interest and this meeting represents the only conference that directly addresses muscle satellite and stem cell populations. The biennial timing of this multidisciplinary conference has facilitated the presentation of new unpublished data that has generated considerable discussion and promoted collaborative interactions. Eight plenary sessions presenting 44 speakers (16 to be selected from submitted abstracts) at the senior, mid-level and junior levels will address: epigenetic and post- transcriptional control of satellite cells, non-myogenic cells in muscle that influence satellite cell biology, biology of satellite cells in the had muscles, satellite cell quiescence, activation and self-renewal, the molecular control of myogenic lineage progression and differentiation, satellite cells in growth and hypertrophy, and satellite cells in aging and disease. Three dedicated poster sessions that feature these and related topics will be held. Importantly, the participants of this conference will represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries for the field. The conference will further promote collaborative interactions in an attempt to promote future advancements and translational initiatives directed toward the treatment and cure of patients with myopathic diseases. PUBLIC HEALTH RELEVANCE: The aim of this conference is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cells and their role in growth, regeneration, and therapeutics. Understanding the biology of satellite cells and other muscle-derived stem cells at the molecular and cellular levels will lead to new insights that will hasten development of therapeutic approaches to treating disease, injuries and aging of skeletal muscle.

描述（由申请人提供）：本申请为即将到来的美国实验生物学社会联合会（FASEB）会议寻求部分支持，标题为“骨骼肌肉卫星和干细胞”，该会议将于2012年8月12日至17日在意大利卢卡举行。我们预计世界各地约有185名参与者。这次会议的总体目的是强调与肌原干细胞和祖细胞群体（例如卫星细胞）的调节机制有关的最新进展及其在发育，再生，肥大，衰老和肌病状态中的作用。这将是针对卫星细胞/干细胞和肌肉再生的第七届会议。从第一次会议到第六次会议的参与增加表明需要进行专门针对卫星和干细胞的会议。从上六次会议的成功来看，这个话题引起了人们的兴趣，这次会议代表了唯一直接解决肌肉卫星和干细胞种群的会议。这个多学科的每两年时间安排会议促进了新的未发表数据的介绍，这些数据已经引起了广泛的讨论并促进了协作互动。在高级，中级和初级级别呈现44位演讲者（从提交的摘要中选择的16位）的八个全体会议将解决：卫星细胞的表观遗传和转录后控制，在肌肉中的非肌源性细胞，影响卫星细胞生物学的肌肉中的非肌动物细胞，卫星细胞的生物学细胞，卫星细胞的生物学细胞，卫星细胞，摩擦性，自动化，自动化，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，激活，反射性。进展和分化，生长和肥大中的卫星细胞以及衰老和疾病中的卫星细胞。将举行三个专用海报会议，其中包含这些主题和相关主题。重要的是，本次会议的参与者将代表跨学科的团体，这些群体将对该领域的最新发现进行全面的分析和整合。该会议将进一步促进协作互动，以促进针对治疗和治愈肌病患者的未来进步和转化计划。公共卫生相关性：本次会议的目的是强调与肌源性干细胞的调节机制有关的最新进展及其在生长，再生和疗法中的作用。了解分子和细胞水平上卫星细胞和其他肌肉衍生的干细胞的生物学将导致新见解，这将加快治疗疾病，损伤和骨骼肌衰老的治疗方法的发展。