FASEB SRC on Skeletal Muscle Satellite and Stem Cells

FASEB SRC 关于骨骼肌卫星和干细胞

• 批准号: 8397854
• 负责人: Grace K Pavlath
• 金额: $ 2.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8397854
• 关键词: Activities of Daily Living; Address; Adult; Aging; American; Basal lamina; Basic Science; Biology; Cell Communication; Cells; Cellular biology; Clinical Sciences; Data; Development; Disease; Environment; Epigenetic Process; Exercise; Fertilization; Future; Growth; Hypertrophy; Individual; Injury; Investigation; Italy; Lead; Location; Molecular; Muscle; Muscle satellite cell; Muscular Atrophy; Natural regeneration; Participant; Patients; Population; Post-Transcriptional Regulation; Process; Proliferating; Regenerative Medicine; Research; Research Personnel; Role; Science; Skeletal Muscle; Skeletal Muscle Satellite Cells; Societies; Stem cells; Stimulus; Therapeutic; Time; Tissues; Trauma; abstracting; adult stem cell; age effect; age related; insight; interest; meetings; multidisciplinary; muscle degeneration; muscle regeneration; posters; programs; regenerative; response; satellite cell; self-renewal; stem; stem cell biology; stem cell population; success; symposium; therapeutic development

DESCRIPTION (provided by applicant): This application seeks partial support for the upcoming Federation of American Societies of Experimental Biology (FASEB) conference entitled, Skeletal Muscle Satellite and Stem cells, that will be held on August 12-17, 2012 in Lucca, Italy. We expect approximately 185 attendees from around the world. The overall objective of this meeting is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cell and progenitor cell populations (such as satellite cells) and their role in development, regeneration, hypertrophy, aging and myopathic states. This will be the 7th conference focused on satellite cells/stem cells and muscle regeneration. The increased participation from the first to the sixth meetings has demonstrated the need for a conference dedicated to satellite and stem cells. It is clear from the successes of the previous six meetings that this topic is of high interest and this meeting represents the only conference that directly addresses muscle satellite and stem cell populations. The biennial timing of this multidisciplinary conference has facilitated the presentation of new unpublished data that has generated considerable discussion and promoted collaborative interactions. Eight plenary sessions presenting 44 speakers (16 to be selected from submitted abstracts) at the senior, mid-level and junior levels will address: epigenetic and post- transcriptional control of satellite cells, non-myogenic cells in muscle that influence satellite cell biology, biology of satellite cells in the had muscles, satellite cell quiescence, activation and self-renewal, the molecular control of myogenic lineage progression and differentiation, satellite cells in growth and hypertrophy, and satellite cells in aging and disease. Three dedicated poster sessions that feature these and related topics will be held. Importantly, the participants of this conference will represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries for the field. The conference will further promote collaborative interactions in an attempt to promote future advancements and translational initiatives directed toward the treatment and cure of patients with myopathic diseases. PUBLIC HEALTH RELEVANCE: The aim of this conference is to highlight recent advances pertaining to the regulatory mechanisms of myogenic stem cells and their role in growth, regeneration, and therapeutics. Understanding the biology of satellite cells and other muscle-derived stem cells at the molecular and cellular levels will lead to new insights that will hasten development of therapeutic approaches to treating disease, injuries and aging of skeletal muscle.

描述（由申请人提供）：本申请寻求对即将于 2012 年 8 月 12 日至 17 日在意大利卢卡举行的美国实验生物学会联合会 (FASEB) 会议的部分支持，该会议题为“骨骼肌卫星和干细胞” 。我们预计将有来自世界各地的大约 185 名与会者。本次会议的总体目标是强调有关肌源干细胞和祖细胞群（例如卫星细胞）调节机制及其在发育、再生、肥大、衰老和肌病状态中的作用的最新进展。这将是第七届专注于卫星细胞/干细胞和肌肉再生的会议。从第一次到第六次会议的参与人数不断增加，表明有必要召开一次专门讨论卫星和干细胞的会议。从前六次会议的成功经验可以清楚地看出，这个主题引起了人们的高度关注，并且本次会议是唯一直接讨论肌肉卫星和干细胞群的会议。这个多学科的项目每两年举办一次 会议促进了新的未发表数据的展示，这些数据引发了大量讨论并促进了协作互动。八场全体会议，有 44 名高级、中级和初级级别的发言者（从提交的摘要中选出 16 名）将讨论：卫星细胞的表观遗传和转录后控制、影响卫星细胞生物学的肌肉中的非生肌细胞、肌肉中卫星细胞的生物学，卫星细胞静止、激活和自我更新，肌源谱系进展和分化的分子控制，生长和肥大中的卫星细胞，以及衰老和疾病中的卫星细胞。将举办三场以这些及相关主题为主题的专门海报会议。重要的是，本次会议的参与者将代表跨学科团体，他们将对该领域的最新发现进行全面分析和整合。会议将进一步促进合作互动，以促进针对肌病患者治疗和治愈的未来进步和转化举措。 公共健康相关性：本次会议的目的是强调有关肌源干细胞调节机制及其在生长、再生和治疗中的作用的最新进展。在分子和细胞水平上了解卫星细胞和其他肌肉干细胞的生物学特性将带来新的见解，从而加速治疗骨骼肌疾病、损伤和衰老的治疗方法的发展。