Clinical Evaluation of an Ultrasound Based Imaging System for Guiding Cardiac Abl

指导心脏功能的超声成像系统的临床评价

基本信息

批准号：
8325962
负责人：
PATRICK D WOLF
金额：
$ 68.88万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2014-08-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8325962
关键词：
Ablation Academic Medical Centers Acoustics Anatomy Animal Experiments Animal Testing Animals Arrhythmia Atrial Fibrillation Atrial Flutter Biosensing Techniques Blood Vessels Breast Canis familiaris Cardiac Cardiac ablation Catheters Clinic Clinical Clinical Research Clinical Trials Coagulation Process Collaborations Computer software Development Devices Dimensions Echocardiography Electrophysiology (science)Environment Funding Healthcare Heart Heart Atrium Hour Human Image Imagery Imaging technology In Vitro Institutional Review Boards Kidney Laboratories Laboratory Animals Left Left atrial structure Lesion Liver Location Maps Measures Methods Modification Morbidity - disease rate Multimodal Imaging Myocardial Navigation System Patients Phase Physicians Physiologic pulse Positioning Attribute Procedures Process Property Pulmonary veins Puncture procedure Qualifying Radiation Radiofrequency Interstitial Ablation Research Right atrial structure Series Services System Tachyarrhythmias Techniques Technology Testing Three-Dimensional Imaging Time Tissues Ultrasonography United States Ventricular Wolves Work base computerized data processing image guided therapy image processing imaging modality meetings migration novel performance tests prevent programs prototype public health relevance research clinical testing tool

项目摘要

DESCRIPTION (provided by applicant): We propose to clinically evaluate the ability of a novel intracardiac ARFI ultrasound imaging system combined with an electro-anatomic mapping system to guide radio-frequency ablations procedures for treating atrial fibrillation and atrial flutter. In parallel, and in collaboration with our industrial partner Siemens Ultrasound, we will migrate these technologies to a 3D ultrasonic imaging platform and develop two intracardiac probes optimized for combined 3D B-mode/ARFI imaging. Phantom, animal and, ultimately, human studies are proposed to evaluate the 3D scanner/probes and the related pulse sequences, beam forming methods and signal and image processing methods to be developed. If successful, the proposed methods will provide the electrophysiologist with real-time visualization of cardiac ablation lesions and with the ability guide the creation of these lesions. As such, the proposed studies could markedly reduce treatment times for atrial and ventricular cardiac ablation procedures, prevent complications from over ablation and reduce the rates of repeat procedures. PUBLIC HEALTH RELEVANCE: We propose to move from the laboratory to the clinic the technique we developed in Phase I for image guided ablation therapy. This system can show the physician regions of the heart which have already been treated. Currently physicians have no means to examine these regions. In Phase I we successfully built the system and demonstrated its efficacy. In phase II we plan a series of clinical tests to demonstrate its utility for treating atrial arrhythmias in patients.

描述（由申请人提供）：我们建议在临床上评估新型的ARFI超声成像系统与电解映射系统相结合的能力，以指导射频消融程序，以治疗心房纤维化和心房颤音。并行，并与我们的工业合作伙伴西门子的超声一起合作，我们将将这些技术迁移到3D超声成像平台，并开发出针对组合的3D B模式/ARFI成像优化的两个心脏内探针。幻影，动物以及最终提出了人类研究，以评估要开发的3D扫描仪/探针以及相关的脉冲序列，束形成方法以及信号和图像处理方法。如果成功的话，所提出的方法将为电生理学家提供心脏消融病变的实时可视化，并以能力指导这些病变的产生。因此，拟议的研究可以显着减少心房和心室消融程序的治疗时间，防止并发症过度消融并降低重复程序的速度。公共卫生相关性：我们建议从实验室转移到诊所，我们在I阶段为图像指导消融治疗中开发的技术。该系统可以显示已经被治疗的心脏的医师区域。目前，医师没有检查这些地区。在第一阶段，我们成功构建了该系统并证明了其功效。在第二阶段，我们计划了一系列临床测试，以证明其用于治疗患者心房心律失常的实用性。