Clinical and Translational Research Core

临床和转化研究核心

• 批准号: 8433285
• 负责人: Uptal D Patel
• 金额: $ 32.83万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8433285
• 关键词: Address; Area; Back; Basic Science; Biological; Biometry; Cardiovascular Diseases; Chronic Kidney Failure; Clinic; Clinical; Clinical Research; Collaborations; Communication; Data; Data Analyses; Data Set; Databases; Development Plans; Epidemiology; Evaluation; Fostering; Functional disorder; Goals; Heart Diseases; Heart failure; Human; Hypertension; Individual; Institutes; Institutional Review Boards; Interdisciplinary Study; Investigation; Kidney; Kidney Diseases; Link; Nephrology; Prevention; Protocols documentation; Public Health; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Research Support; Resources; Risk; Risk Factors; Sampling; Science; Source; Translating; Translational Research; Translations; Validation; Work; base; biobank; biological systems; cardiovascular disorder risk; data management; effective intervention; improved; multidisciplinary; prevent; repository; translational medicine; treatment response

Chronic kidney disease is both a cause and consequence of hypertension (HTN), and both CKD and HTN are independent risk factors for cardiovascular disease (CVD). Thus CKD, CVD and HTN are closely inter-related, and the investigation of each in relation to the others holds the greatest promise for improving the public health. Clinical and translational research can advance understanding of these inter-relationships by evaluating the relevance of basic science discoveries to these conditions in humans, and by identifying associations in humans that warrant validation in biological systems. The Clinical and Translational Core of the Duke O'Brien Center for Kidney Research (DOCK) builds on an outstanding track record of human research in CKD, CVD and HTN. However, this research base has generally operated as 3 separate research agendas. The proposed Core will encourage and facilitate expansion of each area into multi-disciplinary research that addresses the thematic focus of DOCK: the kidney in hypertension and the unique links between the kidney and cardiovascular disease. The Core will capitalize on existing relationships of investigators in Duke Nephrology with the Duke Translational Medicine Institute (DTMI), the Duke Clinical Research Institute (DCRI), and other entities within DTMI. Core investigators will expand our understanding of mechanisms, translate and/or validate findings from the other Cores into human studies, and develop strategies for implementing effective interventions addressing our thematic area of focus. The proposed Clinical and Translational Core has four functional units: 1) a Study Implementation Group to provide oversight and project management; 2) a Biostatistics Unit to provide support for study design, data analysis, and data management; 3) a Biological Samples Unit to provide access to existing biological sample repositories; and 4) a Database Unit to provide access to existing clinical data repositories. These resources will provide foundational support for a wide range of clinical research approaches by a diverse, multidisciplinary group of clinical and translational investigators. This Core will foster collaboration and communication among Core investigators and across the other Cores within the DOCK, potentially leading to bi-directional translation of findings from clinic to bench and back. Thus the proposed Clinical and Translational Core will promote powerful interdisciplinary research that will move science forward in addressing the inter-relationships among CKD, CVD and HTN.

慢性肾脏疾病既是高血压（HTN）的原因和后果，而CKD和HTN都是心血管疾病（CVD）的独立危险因素。因此，CKD，CVD和HTN密切相关，并且对其他人的调查是改善公共卫生的最大希望。临床和转化研究可以通过评估基础科学发现与人类的这些状况的相关性，并通过确定需要在生物系统中验证的人类的关联来提高对这些关系的理解。奥布莱恩肾脏研究中心（DOCK）的临床和转化核心以CKD，CVD和HTN的人类研究的出色记录为基础。但是，该研究基础通常以3个单独的研究议程运行。提出的核心将鼓励和促进每个区域扩展到多学科研究中，该研究涉及码头的主题重点：高血压的肾脏以及肾脏和心血管疾病之间的独特联系。核心将利用杜克大学杜克大学的现有关系与杜克翻译医学研究所（DTMI），杜克临床研究所（DCRI）和DTMI中的其他实体。核心研究人员将扩大我们对机制，转化和/或验证其他核心发现的理解，并制定实施针对我们主题重点领域的有效干预措施的策略。拟议的临床和转化核心具有四个功能单元：1）一个研究实施小组，以提供监督和项目管理； 2）生物统计学单元，以提供研究设计，数据分析和数据管理的支持； 3）一个生物样品单元，可提供现有的生物样品存储库； 4）一个数据库单元，可提供对现有临床数据存储库的访问。这些资源将为各种各样的临床和转化调查人员组成的多种临床研究方法提供基本的支持。该核心将促进核心调查员以及码头中其他核心之间的协作和沟通，这可能导致从诊所到长凳和背部的发现的双向翻译。因此，拟议的临床和转化核心将促进强大的跨学科研究，该研究将推动科学在解决CKD，CVD和HTN之间的关系方面。