Summer Research and Training Program in Environmental Health Sciences

环境健康科学夏季研究和培训计划

• 批准号: 7783764
• 负责人: F PETER Guengerich
• 金额: $ 1.18万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-08 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7783764
• 关键词: Antioxidants; Applications Grants; Area; Biological; Biomedical Research; Chemical Agents; Chemicals; Clinical Research; Coupled; DNA; Development; Discipline; Doctor of Medicine; Environmental Health; Enzymes; Event; Faculty; Funding; Genetic; Intervention; Investigation; Kidney; Manganese; Medical Students; Mentors; Mercury; Metals; Neurologic; Nitrogen; Oxygen; Participant; Physicians; Research; Research Personnel; Research Project Grants; Research Training; Role; Scientist; Signal Pathway; Structure-Activity Relationship; Students; Training Programs; Training and Infrastructure; Universities; career; cell injury; design; experience; improved; medical schools; member; patient oriented research; planetary Atmosphere; pre-doctoral; programs; research facility; response

DESCRIPTION (provided by applicant) This T35 grant application is designed to support medical students involved in a Summer Research and Training Program in Environmental Health Sciences. The proposed program will capitalize on the outstanding research facilities at the Vanderbilt University, School of Medicine, strengths in environmental health coupled with patient-oriented research, existing research and training infrastructure, and a demonstrated institutional commitment to the continued development of biomedical research and training. Funds are requested to support ten pre-doctoral short-term trainees per year (M.D. candidates). The list of preceptors includes twenty-eight faculty members representing basic and clinical research disciplines. Students will have the opportunity to participate in research projects in a variety of areas including mechanisms of cell damage by reactive oxygen and nitrogen species, biological intervention by antioxidants, chemical damage to DNA and genetic stability, signaling pathways induced as a response to genetic damage, structure-function relationships in mutagenic events, roles of enzymes in influencing damage from chemical agents, and mechanisms of neurological and renal damage induced by metals (especially manganese and mercury). The primary objective of this program is to provide a meaningful research experience in the field of environmental health sciences to medical students early in their academic careers and encourage more towards careers as physician-scientists. To achieve this objective, the program aims to 1) provide the medical student with the opportunity to conduct mentor-guided research in order to gain an improved understanding of biomedical research and career opportunities in the field; 2) provide students with information about what is involved in a career in biomedical investigation; 3) provide an atmosphere that encourages and facilitates student interaction with a diverse group of established investigators and clinicians in the broad area of environmental health sciences; and, 4) give participants a comprehensive and current overview of environmental health sciences and unsolved research problems in the field.

描述（由申请人提供） 该 T35 拨款申请旨在支持参与环境健康科学夏季研究和培训项目的医科学生。 拟议的计划将利用范德比尔特大学医学院出色的研究设施、环境健康方面的优势以及以患者为导向的研究、现有的研究和培训基础设施，以及对持续发展生物医学研究和培训的明确机构承诺。 每年申请资金支持十名博士前短期培训生（医学博士候选人）。 导师名单包括代表基础和临床研究学科的二十八名教员。 学生将有机会参与各个领域的研究项目，包括活性氧和氮物种造成的细胞损伤机制、抗氧化剂的生物干预、对 DNA 的化学损伤和遗传稳定性、因遗传损伤而诱导的信号通路、诱变事件中的结构-功能关系、酶在影响化学试剂损伤中的作用以及金属（特别是锰和汞）引起的神经和肾脏损伤的机制。 该计划的主要目标是在医学生学术生涯的早期为他们提供环境健康科学领域有意义的研究经验，并鼓励更多人从事医师科学家的职业。 为了实现这一目标，该计划旨在 1) 为医学生提供进行导师指导研究的机会，以更好地了解该领域的生物医学研究和职业机会； 2）向学生提供有关生物医学研究职业所涉及的信息； 3）提供一种氛围，鼓励和促进学生与环境健康科学广泛领域内的不同群体的既定研究人员和临床医生进行互动； 4) 为参与者提供环境健康科学和该领域未解决的研究问题的全面、最新的概述。