Global Network for Women's and Children's Health

全球妇女儿童健康网络

基本信息

批准号：
8226891
负责人：
EDWARD A. LIECHTY
金额：
$ 5.89万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-17 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8226891
关键词：
Acquired Immunodeficiency Syndrome Acute Adherence Admission activity Africa African Age-Months Behavioral Sciences Bioethics Biological Preservation Biometry Catchment Area Certification Cessation of life Child Child health care Childhood Chlorine Clinical Research Communities Computerized Medical Record Control Groups Data Data Collection Databases Developing Countries Diarrhea Discipline of obstetrics Education Ensure Epidemiology Failure Failure to Thrive Family Funding Agency Growth Head circumference Health Health Personnel Health Promotion Healthcare Home environment Home visitation Hospital Referrals Hospitals House Call Household Incidence Indiana Individual Infant Infant Health Infant Mortality Institution Institutional Review Boards International Intervention Joints Kenya Lead Length Live Birth Lung diseases Medical Records Morbidity - disease rate Mothers Multi-Institutional Clinical Trial Neck Neonatal Neonatal Mortality Pediatric Research Population Prevention Prevention approach Principal Investigator Professional counselor Protocols documentation Public Health Qualifying Randomized Recording of previous events Rehydrations Reporting Research Research Activity Research Infrastructure Research Personnel Residual state Resources Rural Rural Health Rural Health Centers Site Social Marketing Social Welfare Sodium Hypochlorite Stress Supplementation System Testing Time Training Universities Vaccination Village Health Workers Vitamin A Water Weaning Weight Woman Zinc base chlorination clinical application clinical care data management design disorder prevention drinking water follow-up group intervention high risk infant improved indexing international center medical schools member mortality nutrition peer postnatal programs protocol development respiratory wasting water sampling water treatment working group

项目摘要

DESCRIPTION (provided by applicant): We propose to develop a Global Network for Women's and Children's Health Research site in Eldoret, Kenya. This East African site will be a joint partnership between Indiana University and Moi University School of Medicine, one of two medical schools in Kenya. The 17 year partnership of Moi University and Indiana University will bring unique strengths to the Global Network. These include an established administrative, scientific, and collegial relationship between the institutions, an extensive research infrastructure that includes an established network of rural health centers from which to draw subjects, a well functioning Kenyan Institutional Review Board with a OHRP Assurance number, and an established expanding coverage of subjects by an electronic medical record. The Senior Foreign Investigator is Dean of the Medical School, and has well established relationships with high level Ministry of Health personnel. A large number of other Moi University investigators with expertise in Obstetrics, Public Health, Nutrition, Epidemiology, and Behavioral Sciences are also eager to join the Global Network. US based expertise is also present in Obstetrics, Biostatistics, and Bioethics. We propose to the Network a cluster randomized protocol evaluating the efficacy of both Community Mobilization for the use of a Safe Water System (SWS) and for zinc supplementation in partially weaned infants less than 6 months of age. The SWS includes specially designed narrow neck water storage containers and point of use home chlorination using dilute sodium hypochlorite. Hypotheses to be tested are that 1.) Community Mobilization will result in sustained, consistent use of point of use water treatment 2.) This will lead to a decreased incidence of diarrhea in less than 6 month old infants. 3.) Zinc supplementation beginning at partial weaning will lead to a further decrease in the incidence of diarrhea in these infants. 4.) Growth will be improved and failure to thrive decreased in experimental groups. 5.) All cause mortality in >6 month old infants will be decreased in experimental groups. If efficacy is shown, these are highly sustainable interventions that will improve the health and well being of vulnerable infants.

描述（由申请人提供）：我们建议在肯尼亚Eldoret开发一个针对妇女和儿童健康研究网站的全球网络。这个东非地点将是印第安纳大学和肯尼亚两所医学院之一的MOI大学医学院之间的联合合作伙伴关系。 MOI大学和印第安纳大学的17年合作伙伴关系将为全球网络带来独特的优势。其中包括机构之间既定的行政，科学和合作关系，这是一个广泛的研究基础设施，其中包括一个既定的农村卫生中心网络，可以从中吸引受试者，这是一个运作良好的肯尼亚机构审查委员会，具有OHRP的保证号，以及通过电子医疗记录的既扩大对象的扩大对象的范围。外国高级调查员是医学院的院长，与高级卫生部人员建立了良好的关系。许多其他MOI大学的研究人员在妇产科，公共卫生，营养，流行病学和行为科学方面具有专业知识，也渴望加入全球网络。美国的专业知识也存在于产科，生物统计学和生物伦理学中。我们向网络提出了一个群集随机协议，该方案评估了社区动员使用安全供水系统（SWS）的功效，并在不到6个月大的部分中含有锌的锌补充。 SWS包括特殊设计的窄颈储藏容器，并使用稀钠次氯酸钠使用家用氯化。要测试的假设是1.）社区动员将导致持续，持续使用用水处理。 3.）补充部分断奶时的锌补充将导致这些婴儿腹泻的发生率进一步降低。 4.）实验组的增长将得到改善，未能下降。 5.）在实验组中，这一切都会导致> 6个月大的婴儿死亡率降低。如果显示功效，这些是高度可持续的干预措施，可以改善脆弱婴儿的健康和福祉。