Cohort Follow-up and Database Maintenance

队列跟进和数据库维护

基本信息

批准号：
8250808
负责人：
ERIC B RIMM
金额：
$ 135.55万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8250808
关键词：
1,25 (OH) vitamin D Address Adult Alcohol consumption Alcohols All-Trans-Retinol Alleles Animals Anti-Inflammatory Agents Anti-inflammatory Ascorbic Acid Aspirin Biological Blood Brain Breast C-Peptide C-reactive protein CYP2C9 gene Calcium Calcium Milk Cause of Death Cells Cessation of life Characteristics Cheek structure Chronic Collection Colon Carcinoma Colonic Polyps Colorectal Adenoma Colorectal Cancer Colorectal Neoplasms DNA Dairy Products Data Databases Diabetes Mellitus Diagnosis Diet Dietary Factors Dietary Practices Documentation Down-Regulation Ejaculation Energy Intake Epigenetic Process Estrogen receptor negative Excision Exhibits Fatty acid glycerol esters Fish Products Fishes Folate Folic Acid Frequencies GC gene Genes Genetic Genetic Determinism Genetic Polymorphism Genetic Predisposition to Disease Genetic Variation Germ Lines Glioma Goals Haplotypes Health Professional Hormones Hyperinsulinism Image Incidence Inflammation Inflammatory Insulin Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth-Factor-Binding Proteins Intake Interleukin-6 Link Mails Maintenance Malignant Neoplasms Malignant neoplasm of large intestine Malignant neoplasm of prostate Marines Meat Mediating Medical Records Meta-Analysis Metabolism Methods Methylation Milk Mixed Function Oxygenases Molecular Mutate Names Newsletter Non-Steroidal Anti-Inflammatory Agents Nurses&apos Health Study Obesity Omega-3 Fatty Acids Participant Pathology Pathway interactions Persons Physical activity Plasma Postmenopause Premenopause Principal Investigator Procedures Process Production Prospective Studies Prostate Prostatic Prostatic Tissue Questionnaires RXR Recording of previous events Report (document)Reporting Research Personnel Resources Risk Risk Factors Scanning Smoker Somatomedins Specimen Testing Testosterone Tomatoes Update Variant Vascular Endothelial Growth Factors Vitamin D Vitamin E Vitamins Weight Gain Woman adenoma adiponectin alcohol effect cancer risk cohort computerized data processing cruciferous vegetable density design diet and cancer energy balance follow-up fruits and vegetables high risk men improved indexing inflammatory marker lifestyle factors lycopene malignant breast neoplasm men nutrient blood level overexpression programs prospective repository response tumor waist circumference

项目摘要

The Cohort Follow-up and Database Maintenance core (Core C) serves as the center for data processing, cohort maintenance, cancer documentation, and biospecimen repository for the Health Professionals Follow-up Study, and, thus, it supports each of the projects within this proposal. The goals of the core are to: (1) develop and mail follow-up questionnaires, (2) process, verify and compile a database of exposure data, (3) document reports of incident cases of cancer, (4) identify and ascertain cause of death among all participants, (5) trace lost subjects and maintain a name and address file, and (6) maintain participation through biennial newsletters and correspondence. The core also serves as a resource to all four projects which use stored questionnaire data, plasma and buffy coat from 18,018 men, cheek cells from an additional 17,000 men, and tumor blocks collected from over 2,000 confirmed cancer and adenoma cases. With input from other investigators on the Program Project, Core C develops and designs the biennial follow- up questionnaire sent to study participants to update information on diet, exposure information, physical activity, and major illnesses. While maintaining continuity with previous questionnaires, new and existing hypotheses are also evaluated and specific wording for questions is scrutinized. Returned questionnaires are checked for completeness, optically scanned, verified for scanning errors, digitally imaged, stored, and a database of exposure information is compiled. Core C uses a variety of methods to trace participants and to maintain high levels of participation. For each two-year follow-up cycle, we average a 93% response rate. At present, over 71% of participants responded to the 2004 questionnaire after only a single mailing. From the information collected, incident cases of cancer are documented by obtaining medical records. We estimate that we will need to confirm more than 5000 adenoma and cancer cases over the next 5 years of the study. Most deaths are reported through the questionnaire mailings, and searches of the National Death Index are done after each 2-year questionnaire cycle. A major additional component of the study has come through the collection of biological specimens. Efficient procedures have been developed to obtain pathology blocks for prevalent and incident colon polyps, colon cancer, and prostate cancer cases. Core C serves as a resource to projects which use stored specimens.

队列跟进和数据库维护核心（核心 C）作为数据中心处理、队列维护、癌症记录和健康生物样本存储库专业人员后续研究，因此，它支持该提案中的每个项目。的目标核心是：(1) 制定并邮寄后续调查问卷，(2) 处理、验证和编制数据库暴露数据，(3) 癌症事件病例的文件报告，(4) 识别和确定死亡原因在所有参与者中，（5）追踪丢失的受试者并维护姓名和地址文件，以及（6）维护通过两年一次的通讯和信件参与。该核心还充当所有四个的资源该项目使用存储的问卷数据、18,018 名男性的血浆和血沉棕黄层、来自另外还有 17,000 名男性，以及从 2,000 多个确诊的癌症和腺瘤病例中收集的肿瘤块。根据该计划项目其他研究人员的意见，Core C 开发和设计了两年一次的后续项目向研究参与者发送调查问卷，以更新有关饮食、暴露信息、身体状况的信息活动和重大疾病。在保持与之前调查问卷的连续性的同时，新的和现有的调查问卷还评估假设并仔细审查问题的具体措辞。返回的调查问卷检查完整性、光学扫描、验证扫描错误、数字成像、存储和编制暴露信息数据库。 Core C 使用多种方法来追踪参与者并保持高水平的参与。对于每个两年的随访周期，我们的平均回复率为 93%。目前，超过71%的参与者仅在一次邮寄后就回复了2004年的调查问卷。从收集到的信息，通过获取医疗记录来记录癌症事件病例。我们估计未来5年我们需要确认超过5000例腺瘤和癌症病例研究。大多数死亡是通过邮寄问卷和搜索全国死亡报告来报告的索引在每个 2 年问卷周期后完成。该研究的一个主要附加部分已经到来通过生物标本的采集。已开发出有效的程序以获得针对常见和偶发的结肠息肉、结肠癌和前列腺癌病例的病理学模块。核心C 作为使用存储样本的项目的资源。