Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network

婴儿猝死综合症和死产中的产前酒精 (PASS) 网络

• 批准号: 8335188
• 负责人: William P. Fifer
• 金额: $ 71.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8335188
• 关键词: Abbreviations; Affect; Alcohol consumption; Alcohols; Anxiety; Autopsy; Biological Neural Networks; Brain; Brain Stem; Cerebral cortex; Child; Child health care; Clinical; Cognitive; Communities; Complex; Data; Data Analyses; Data Collection; Data Coordinating Center; Development; Developmental Biology; Early treatment; Electroencephalography; Enrollment; Environmental Risk Factor; Face; Failure; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Death; Fetal Development; Fetal Growth; Fetal Ultrasonography; Fetus; Forensic Medicine; Functional disorder; Genetic; Goals; Growth; Hearing; Infant; Infant Development; Investigation; Knowledge; Life; Link; Maternal Age; Measures; Mediating; Medical; Mental Depression; Mission; National Institute of Child Health and Human Development; National Institute on Alcohol Abuse and Alcoholism; Neurotransmitters; Outcome; Participant; Pathologic; Pathology; Pattern; Performance; Perfusion; Perinatal; Phase; Physiological; Physiology; Placenta; Pregnancy; Pregnancy Outcome; Principal Investigator; Public Health; Reporting; Request for Applications; Research; Research Infrastructure; Risk; Role; Scientist; Site; Stress; Structure; Sudden infant death syndrome; Synapses; Testing; Time; Ultrasonography; Variant; Work; adverse outcome; aging nutrition; base; clinical research site; critical period; fetal; fetal tobacco exposure; follow-up; high risk; improved; in vivo; indexing; infant death; interest; neurobehavioral; northern plains; prenatal; prevent; programs; resilience; response; stillbirth; tobacco exposure

DESCRIPTION (provided by applicant): The goal of the PASS Network is to determine the role of prenatal alcohol exposure in the risk for the sudden infant death syndrome (SIDS) and adverse outcomes of pregnancy, particularly stillbirth and fetal alcohol spectrum disorders (FASD), and in the potential inter-relationships between SIDS, stillbirth, and FASD. This application is in response to the Request for Application (RFA-HD-10-018) entitled "Role of Prenatal Alcohol Exposure in SIDS and Stillbirth". As requested, it proposes the completion of enrollment and follow-up of study participants and the performance of data analysis in Phase II of the PASS Network by the current five clinical, physiologic, biologic/pathologic, and data coordinating centers. The mission of the network is to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FAS, and to determine how these different outcomes are inter-related. The PASS Network is a collaborative effort comprised of two Comprehensive Clinical Sites (CCS) - Northern Plains Comprehensive Clinical Site (NPCCS) and Stellenbosch Comprehensive Clinical Site (SCCS), a Developmental Biology and Pathology Center (DBPC), a Physiology Assessment Center (PAC), and a centralized Data Coordinating and Analysis Center (DCAC) and program scientists and officers at the NICHD and NIAAA. This particular application pertains to the Physiology Assessment Center (PAC) of the PASS Network. The role of the PAC is to oversee the data collection infrastructure and analyze the physiological data from the 12,000 subjects tested at the PASS Network Clinical Sites. These early assessments will define physiological consequences of prenatal alcohol and other exposures prior to the development of adverse outcomes. The potential impact of this work is that, in combination with pathological, environmental and genetic findings, we will be better able to define the mechanisms that underlie vulnerability to stillbirth SIDS and FASD. The information gained will provide the potential for prospectively identifying fetuses and infants at greatest risk and the possibility for more precise targeting of early interventions. PUBLIC LEALTH RELEVANCE: The PASS Network will perform community-linked studies to determine the role of prenatal alcohol exposure in the risk for SIDS and adverse pregnancy outcomes, especially stillbirth and FASD. The study hopes to decrease fetal and infant death and improve child health in communities at high risk for prenatal maternal alcohol consumption.

描述（由申请人提供）：通过网络的目的是确定产前酒精暴露在婴儿突然死亡综合征（SIDS）和怀孕不良后果的风险中的作用，尤其是死产和胎儿酒精疾病（FASD）（FASD），以及在SIDS和SIDS之间的潜在相互作用，以及SIDS之间的潜在相互关系。此申请是对申请请求（RFA-HD-10-018）的响应，标题为“产前酒精暴露在SID和死产中的作用”。根据要求，它提议完成研究参与者的入学和随访以及通过当前五个临床，生理，生物学/病理和数据协调中心的PASS网络II阶段分析的性能。该网络的任务是进行社区关联的研究，以研究产前酒精暴露在SID，死产和FAS风险中的作用，并确定这些不同结果如何相互关联。通行网络是由两个综合临床站点（CCS）组成的合作努力 - 北部平原综合临床站点（NPCCS）和Stellenbosch综合临床站点（SCCS）（SCCS），一个发育生物学和病理中心（DBPC），一个生理学评估中心（PAC），以及中央数据协调和计划中心和分析中心（DCAC），以及分析中心（PAC），并进行了分析中心（DCAC）（DCAC）（DCAC）。 NIAAA。该特定应用与通行网络的生理评估中心（PAC）有关。 PAC的作用是监督数据收集基础架构并分析来自Pass网络临床部位测试的12,000名受试者的生理数据。这些早期评估将定义产前酒精和其他暴露的生理后果，然后发展不良后果。这项工作的潜在影响是，与病理，环境和遗传发现结合在一起，我们将更好地定义了脆弱性的脆弱性SIDS和FASD的机制。获得的信息将为前瞻性地识别具有最大风险的胎儿和婴儿的潜力，以及更精确地靶向早期干预措施的可能性。 公共Lealth相关性：PASS网络将进行社区关联的研究，以确定产前酒精暴露在SID和不良怀孕结果（尤其是死产和FASD）风险中的作用。该研究希望减少胎儿和婴儿死亡，并改善产前孕妇饮酒风险高风险的社区的儿童健康。