Etiology and Neuropsychology of Math, Reading, ADHD, and their Covariation

数学、阅读、多动症及其协变的病因学和神经心理学

• 批准号: 8256780
• 负责人: STEPHEN A. PETRILL
• 金额: $ 60.23万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256780
• 关键词: Accounting; Address; Attention deficit hyperactivity disorder; Behavior; Behavioral; Childhood; Classification; Cognitive; Comorbidity; Complex; Comprehension; DSM-IV; Data Set; Development; Dimensions; Disease; Etiology; General Practitioners; Genes; Genetic; Growth; Hyperactive behavior; Impulsivity; Individual Differences; Intercept; International; Knowledge; Lead; Longitudinal Studies; Math disability; Measures; Modeling; Names; Neuropsychology; Nursery Schools; Outcome; Printing; Problem Solving; Process; Psychometrics; Reading; Reading Disabilities; Reporting; Risk Factors; Sampling; Short-Term Memory; Speed; Structure; Symptoms; Testing; Time; Twin Multiple Birth; Twin Studies; Vocabulary; disorder subtype; inattention; neuropsychological; ninth grade; phonology; population based; processing speed; public health relevance; response

DESCRIPTION (provided by applicant): Reading disability (RD), math disability (MD), and attention-deficit/hyperactivity disorder (ADHD) are common disorders of childhood that frequently co-occur, but the developmental etiology of this comorbidity is largely unknown. The proposed project is an extension of the Western Reserve Reading and Math Project and the International Longitudinal Twin Study of Early Reading Development, two longitudinal twin studies that have followed population-based samples of twins since preschool. The twins will complete an extensive battery of measures of reading, math, ADHD, and neuropsychological functioning at the end of ninth grade. These measures will provide important new information regarding the developmental etiology of word reading and more complex reading fluency and comprehension, the developmental stability of DSM-IV symptom dimensions and subtypes of ADHD, and the longitudinal and cross-sectional etiology of covariance between individual differences and extreme scores on measures of reading, math, and ADHD symptoms. The extensive battery of neuropsychological measures will be used to test which neuropsychological functions are uniquely associated with RD, ADHD, or MD and which are shared risk factors across two or more of these domains, and multivariate twin analyses will be conducted to test the etiology of these associations. PUBLIC HEALTH RELEVANCE: Reading disability (RD), math disability (MD), and attention-deficit/hyperactivity disorder (ADHD) are common disorders of childhood that often co-occur due to unknown causes. This study will administer measures of neuropsychological functioning to two large longitudinal studies of twins to assess the genetic, environmental, and neuropsychological factors that lead to stability and change in each disorder and the specific factors that lead to their frequent co-occurrence.

描述（由申请人提供）：阅读障碍（RD），数学障碍（MD）和注意力缺陷/多动症障碍（ADHD）是童年的常见疾病，经常同时发生，但是这种合并症的发展病因在很大程度上是未知的。 拟议的项目是西方储备阅读和数学项目的延伸以及《早期阅读开发》的国际纵向双胞胎研究，两项纵向双胞胎研究遵循自幼儿园以来基于人群的双胞胎样本。 双胞胎将在九年级结束时完成广泛的阅读，数学，ADHD和神经心理功能的衡量标准。 这些措施将提供有关单词阅读以及更复杂的阅读流畅性和理解力，DSM-IV症状维度和ADHD的亚型的发育稳定性的重要新信息，以及在阅读，数学和ADHD症状的测量中，个体差异之间的纵向和横截面病因。 大量的神经心理学措施将用于测试哪些神经心理学功能与RD，ADHD或MD唯一相关，并且在这些域中的两个或多个域中，哪些是共同的风险因素，以及将进行多变量双胞胎分析以测试这些关联的病因。 公共卫生相关性：阅读障碍（RD），数学障碍（MD）和注意力缺陷/多动症（ADHD）是童年的常见疾病，由于未知原因而经常同时发生。 这项研究将对双胞胎的两项大型纵向研究进行神经心理功能的测量，以评估导致每种疾病的稳定性和变化的遗传，环境和神经心理学因素，以及导致其经常出现的特定因素。