Magnetic Resonance Microscopy of Alzheimers Disease Pathology

阿尔茨海默病病理学的磁共振显微镜

• 批准号: 8250367
• 负责人: Jean Augustinack
• 金额: $ 13.26万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8250367
• 关键词: Alzheimer' s Disease; Anisotropy; Area; Back; Biological; Biological Assay; Biomedical Engineering; Brain; Cell Death; Clinical; Common wart; Data; Data Analyses; Development; Diagnosis; Diagnostic Imaging; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Fiber; Functional disorder; Goals; Hippocampal Formation; Histology; Human; Image; Imaging Techniques; Instruction; Island; Label; Location; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Massachusetts; Measures; Mentors; Methodology; Microscopy; Neocortex; Nerve Degeneration; Neurofibrillary Tangles; Noise; Parietal Lobe; Pathological Staging; Pathology; Perforant Pathway; Property; Protons; Research; Research Personnel; Research Training; Resolution; Sampling; Senile Plaques; Severities; Severity of illness; Signal Transduction; Slice; Specimen; Staging; Structure; Techniques; Temporal Lobe; Training; Training Programs; aging population; career development; case control; data acquisition; density; entorhinal cortex; hippocampal fissure; neuroimaging; neuron loss; neuropathology; novel; programs; reconstruction; tau Proteins; tau-1; tool; white matter

DESCRIPTION (provided by applicant): This career development application describes a combined research and training program that has two fundamental goals: (1) the development of the candidate into a strong and independent investigator in novel high resolution magnetic resonance imaging techniques and neuropathology of Alzheimer's disease (AD) and (2) to define parameters in ex vivo magnetic resonance imaging and accompanying neuropathology and correlate the two different mediums. The candidate is eager to continue AD-related research and to add a new methodology to her training program. Primary training goals will concentrate on three components: (1) the application of novel ex vivo neuroimaging data acquisition techniques, (2) neuropathological assessment of Alzheimer's disease cases and quantitative analysis of neuropathological markers and cell death and (3) apply ex vivo imaging to 3D reconstruction and fiber tractography. The Mentors and Advisors on this proposal and the training setting of the Athinoula A. Martinos Center for Biomedical Engineering and the Massachusetts Alzheimer's Disease Research Center will provide excellent instruction in these areas. The candidate anticipates to develop the fundamentals in advanced neuroimaging techniques and data analysis and implement a strong neuropathological and quantitative analysis on Alzheimer's disease cases to develop an enduring research program that targets our aging population and incorporates the two diverse techniques, neuropathology of Alzheimer's disease and high resolution neuroimaging. The proposed research will combine novel ultra high field, high resolution ex vivo imaging with neuropathological assessment of AD to delineate the ex vivo imaging parameters in AD cases and to determine whether ex vivo images follow the staging of severity as in AD neuropathology and whether diffusion tensor imaging (DTI) measures reflect with the temporal lobe neurodegeneration, especially the perforant pathway. Specimens will be received from the Massachusetts Alzheimer's Disease Research Center. Neuroimaging data will be correlated to the clinical and neuropathological data. The Specific Aims of this research are: Aim 1: Identify the hierarchy in ex vivo MRI using histology in clinically and neuropathologically diagnosed AD cases. Aim 2: Identify the effect of white matter degeneration in the perforant pathway using DTI. Aim 3: Identify the T2* sequences in ex vivo imaging and relate to neuropathological markers. The proposed research and training program will yield novel applications to Alzheimer's diagnosis and treatment.

描述（由申请人提供）：该职业发展申请描述了一个综合研究和培训计划，该计划有两个基本目标：（1）将候选人发展成为新型高分辨率磁共振成像技术和阿尔茨海默氏症神经病理学领域的强大且独立的研究者疾病（AD）和（2）来定义离体磁共振成像和伴随的神经病理学参数，并将两种不同的介质关联起来。该候选人渴望继续进行 AD 相关研究，并在她的培训计划中添加新的方法。主要培训目标将集中在三个组成部分：（1）新型离体神经影像数据采集技术的应用，（2）阿尔茨海默病病例的神经病理学评估以及神经病理标志物和细胞死亡的定量分析，以及（3）将离体成像应用于3D 重建和纤维束成像。该提案的导师和顾问以及 Athinoula A. Martinos 生物医学工程中心和马萨诸塞州阿尔茨海默病研究中心的培训环境将在这些领域提供出色的指导。候选人预计将发展先进的神经影像技术和数据分析的基础知识，并对阿尔茨海默病病例实施强大的神经病理学和定量分析，以开发一项持久的研究计划，该计划针对我们的老龄化人口，并结合了两种不同的技术：阿尔茨海默病的神经病理学和高分辨率神经影像。拟议的研究将新型超高场、高分辨率离体成像与 AD 的神经病理学评估相结合，以描绘 AD 病例的离体成像参数，并确定离体图像是否遵循 AD 神经病理学中的严重程度分期，以及扩散张量是否成像（DTI）测量反映了颞叶神经变性，尤其是穿通通路。样本将从马萨诸塞州阿尔茨海默病研究中心收到。神经影像数据将与临床和神经病理学数据相关联。这项研究的具体目标是： 目标 1：使用组织学在临床和神经病理学诊断的 AD 病例中识别离体 MRI 的层次结构。目标 2：使用 DTI 确定穿支通路中白质变性的影响。目标 3：在离体成像中识别 T2* 序列并与神经病理学标志物相关。拟议的研究和培训计划将为阿尔茨海默病的诊断和治疗带来新的应用。

项目成果

Memory Part 3: The Role of the Fornix and Clinical Cases.

记忆第 3 部分：穹窿的作用和临床病例。

• DOI: 10.3174/ajnr.a4371
• 发表时间: 2015
• 期刊: AJNR. American journal of neuroradiology
• 作者: Raslau,FD;Augustinack,JC;Klein,AP;Ulmer,JL;Mathews,VP;Mark,LP
• 通讯作者: Mark,LP

Harnessing advances in structural MRI to enhance research on Parkinson's disease.

• DOI: 10.2217/iim.13.8
• 发表时间: 2013-04
• 期刊: Imaging in medicine
• 作者: Ziegler DA;Augustinack JC
• 通讯作者: Augustinack JC

Corrigendum to "Surface based analysis of diffusion orientation for identifying architectonic domains in the in vivo human cortex" [NeuroImage 69 (2013) 87-100].

“基于表面的扩散方向分析，用于识别体内人类皮层的结构域”的勘误表 [NeuroImage 69 (2013) 87-100]。

• DOI: 10.1016/j.neuroimage.2013.04.037
• 发表时间: 2013
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: McNab,JenniferA;Polimeni,JonathanR;Wang,Ruopeng;Augustinack,JeanC;Fujimoto,Kyoko;Stevens,Allison;Triantafyllou,Christina;Janssens,Thomas;Farivar,Reza;Folkerth,RebeccaD;Vanduffel,Wim;Wald,LawrenceL
• 通讯作者: Wald,LawrenceL