CLINICAL TRIAL: THE EFFECT OF VITAMIN D SUPPLEMENTATION ON PRE-DIABETES IN A MIN

临床试验：维生素 D 补充剂对 1 分钟内糖尿病前期的影响

• 批准号: 8173591
• 负责人: Mayer Benson Davidson
• 金额: $ 4.18万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173591
• 关键词: African American; American; American Indian and Alaska Native; Asian Americans; Biological; Cardiovascular Diseases; Caring; Caucasians; Caucasoid Race; Cause of Death; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Dietary intake; Disease; Funding; Genetic Variation; Grant; Hawaiian population; Hispanics; Institution; Latino; Link; Medical; Minority Groups; Non-Insulin-Dependent Diabetes Mellitus; Pacific Island Americans; Play; Prediabetes syndrome; Research; Research Personnel; Resources; Role; Serum; Skin Pigmentation; Source; Sun Exposure; Supplementation; United States National Institutes of Health; Vitamin D; Vitamins; health disparity; high risk; racial difference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease (CVD) and related disorders remain the leading cause of death in the nation and diabetes in strongly linked to CVD. African-Americans, Hispanic/Latino Americans, American Indians, Alaska Natives, some Asian-Americans, Native Hawaiians and other Pacific Islanders, are at particularly high risk for the development o type 2 diabetes. Rates of diabetes in ethnic and racial minorities are presently increased (1) and are projected to continue to increase at an alarming rate (2). Although access to medical care or genetic variations may have a role, an intriguing biological explanation to help explain this health disparity is racial differences in vitamin Dlevels. Racial/ethnic minorities have reduced serum 25-hydroxy vitamin D 925-OHD) levels, with African-Americans having lower levels than Caucasians and Hispanic/Latino Americans having intermediate levels (3-5). The low serum 25-OHD levels in racial/ethnic minorities may be due to increased skin pigmentation, although reduced sun exposure, reduced dietary intake of vitamin D or other factor may also play a role.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 心血管疾病 (CVD) 和相关疾病仍然是该国死亡的主要原因，而糖尿病与 CVD 密切相关。非裔美国人、西班牙裔/拉丁美洲裔美国人、美洲印第安人、阿拉斯加原住民、一些亚裔美国人、夏威夷原住民和其他太平洋岛民患 2 型糖尿病的风险特别高。目前，少数族裔和种族的糖尿病发病率有所增加 (1)，并且预计将以惊人的速度继续增加 (2)。尽管获得医疗保健或遗传变异可能发挥一定作用，但有助于解释这种健康差异的一个有趣的生物学解释是维生素 D 水平的种族差异。少数种族/族裔的血清 25-羟基维生素 D (925-OHD) 水平降低，其中非洲裔美国人的水平低于白种人，西班牙裔/拉丁裔美国人的水平处于中等水平 (3-5)。少数种族/族裔的血清 25-OHD 水平较低可能是由于皮肤色素沉着增加所致，尽管阳光照射减少、维生素 D 膳食摄入量减少或其他因素也可能起到一定作用。