2012 Glycolipid & Sphingolipid Biology Gordon Research Conference

2012 糖脂

• 批准号: 8318983
• 负责人: WALTER M HOLLERAN
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-09 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318983
• 关键词: Animal Model; Apoptosis; Basic Science; Biochemistry; Biological Process; Biology; Cell Communication; Cell Membrane Structures; Cell physiology; Cells; Ceramides; Chemotherapy-Oncologic Procedure; Clinical Trials; Collaborations; Communication; Communities; Complex; Country; Development; Developmental Biology; Diabetes Mellitus; Discipline; Disease; Environment; Etiology; Eye; Fenretinide; Fostering; Functional disorder; Funding; Genetic; Glycolipids; Goals; Homeostasis; Infection; Italy; Knowledge; Learning; Lipids; Malignant Neoplasms; Membrane Microdomains; Membrane Structure and Function; Metabolic syndrome; Metabolism; Microbe; Minority; Modeling; Molecular; Multiple Sclerosis; Neurodegenerative Disorders; Participant; Pathology; Physicians; Plants; Prevention; Regulation; Research; Research Personnel; Role; Safingol; Scientist; Series; Signal Transduction; Signaling Molecule; Social Environment; Sphingolipids; Translational Research; United States National Institutes of Health; Woman; Work; Yeasts; analog; base; cancer chemoprevention; cell growth; innovation; lectures; meetings; mouse model; novel; posters; programs; receptor function; sphingosine 1-phosphate; symposium

DESCRIPTION (provided by applicant): Partial support is requested for the Gordon Research Conference on Glycolipid and Sphingolipid Biology, to be held at Il Ciocco Hotel in Lucca, Italy from April 22-26, 2012. The purpose of the conference is to encourage the transfer of ideas and information within the community of scientists who work at the cutting edge of glycolipid and sphingolipid research, as well as to provide an environment where investigators from other scientific disciplines can learn about, and contribute to, this rapidly evolving field. Sphingolipis participate in many biological processes, including cell growth, differentiation and apoptosis, but only in the past decade have the molecular bases for these functions become clear (i.e., as modulators of membrane structure, cell- cell interactions, receptor functions, and signaling via ceramide, sphingosine 1-phosphate and others potent bioactive lipids). As an understanding of the roles of sphingolipids in disease etiology and treatment--most notably for cancer--has evolved, sphingolipid analogs such as safingol and FTY720, as well as anticancer chemotherapeutics that modify sphingolipid metabolism (such as fenretinide) either have entered clinical trials or have been approved (e.g., FTY720 for multiple sclerosis), illustrating te strong partnership of basic and translational research in this field. Important aspects of this Gordon Research Conference are that it brings together scientists that work in different disciplines, such as basic biochemistry, genetics, developmental biology, cancer chemoprevention and chemotherapy and that it encourages participation of both senior investigators and junior investigators. As with previous Gordon Research Conferences in this series, there will be a significant percentage of participants from countries outside the U.S. as well as participation by women and minorities. Conferees will be encouraged to participate both in the formal lecture/discussion sessions and less formally in poster presentations. The platform sessions will cover leading edge research in basic sphingolipid biology and biochemistry, including multiple sessions devoted to translational aspects of sphingolipid biology; i.e., sphingolipids in metabolic syndrome and diabetes, and as signaling molecules in cancer, infection, and multiple sclerosis. The program will close with a session dedicated to exploring new models for exploring sphingolipid functions in lipid homeostasis and function in yeast, in the eye (in Drososphila), and importantly, in mouse models of cancer. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Glycolipid and Sphingolipid Biology assembles a group of scientists and physicians who are performing research on the cutting edge of their respective fields to define the roles for these complex and bioactive lipids not only in membrane structure, function, cell regulation, but also their roles in many diseases, including lipid storage disorders, diabetes, neurodegenerative disorders, and most- importantly, cancer and its prevention.

描述（由申请人提供）：要求在2012年4月22日至26日在意大利卢卡的Il Ciocco Hotel举行的有关糖脂和鞘脂生物学的戈登研究会议的部分支持。该会议的目的是鼓励在glycolipid and Sphingipic and Sphingipid and Sphingipid and Sphingipid and Sphingsific and Sphinghingipid and Sphinghingipic and Sphinghingipic and Sphinghingipid and Sphinghingipid and sphinghingsific and Sphinghingsific and Sphinghingsific and Sphinghingipid a的范围内的态度。学科可以学习这个迅速发展的领域并为这个迅速发展的领域做出贡献。鞘氨饼参与许多生物学过程，包括细胞生长，分化和凋亡，但 仅在过去的十年中，这些功能的分子碱基变得清晰（即，作为膜结构的调节剂，细胞相互作用，受体功能以及通过Ceramide，Ceramide，Sphingosine 1-磷酸盐和其他有效的生物活性脂质的信号传导）。为了理解鞘脂脂在疾病病因和治疗中的作用 - 特别是对于癌症而言，诸如Safingol和Fty720之类的鞘脂类似物，以及抗癌化学治疗学，以及修改鞘脂的代谢（例如fenretinide）（例如，已批准的范围）（例如，已被批准）（E. G.）在该领域基础研究和转化研究的牢固伙伴关系。这次戈登研究会议的重要方面是，它汇集了在不同学科中工作的科学家，例如基本的生物化学，遗传学，发育生物学，癌症化学预防和化学疗法，并鼓励高级研究人员和初级研究人员参与。与以前的戈登研究会议一样，来自美国以外国家以及妇女和少数民族的参与者将有很大一部分的参与者。鼓励联合会参加正式的演讲/讨论会议，而较少正式参加海报演示。该平台会议将涵盖基本鞘脂生物学和生物化学的领先研究，包括致力于鞘脂生物学转化方面的多个课程；即，代谢综合征和糖尿病中的鞘脂，以及作为癌症，感染和多发性硬化症的信号分子。该程序将通过一个专门探索探索脂质稳态中鞘脂功能的新模型的会议结束，在酵母中，眼睛（在Drosasphila）中，以及在癌症的小鼠模型中的重要性。 公共卫生相关性：戈登糖脂和鞘脂生物学的戈登研究会议组装了一群科学家和医生，他们正在对各自领域的最前沿进行研究，以定义这些复杂和生物活性脂质在膜结构中的角色，而且还在膜结构，功能，细胞调节中，而且还在 许多疾病，包括脂质储存障碍，糖尿病，神经退行性疾病，最重要的是癌症及其预防。