Animal & Instrumentation Core

动物

• 批准号: 8514694
• 负责人: Thomas Heppner
• 金额: $ 36.82万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8514694
• 关键词: Actins; Age; Animal Experiments; Animals; Astrocytes; Biosensor; Boxing; Breeding; Calcium Signaling; Caliber; Caring; Cerebrum; Clip; Communication; Communities; Contracts; Databases; Date of birth; Diet; Disease; Doxycycline; Ear; Endothelial Cells; Endothelium; Ensure; Equipment; Food; Gel; Gender; Genetic; Genotype; Glial Fibrillary Acidic Protein; Goals; Health; Heterozygote; Individual; Laboratories; Location; Mails; Methods; Monitor; Mouse Strains; Mus; Online Systems; Operative Surgical Procedures; Population; Power Sources; Progress Reports; Rattus; Regulation; Research; Research Personnel; Research Project Grants; Schedule; Scheme; Security; Services; Signal Transduction; Smooth Muscle; Smooth Muscle Myocytes; Specific qualifier value; System; Tail; Tetracyclines; Time; Tissues; Transgenic Mice; Transgenic Organisms; Universities; Vermont; Water; Weaning; Work; animal care; base; cerebrovascular; drinking water; feeding; instrumentation; meetings; mouse development; mouse model; novel; offspring; overexpression; programs; promoter; ratiometric; sex; success

The overall goal of the Program Project is to understand mechanisms regulating the cerebral vasculature in normal and disease states. All four projects that constitute this PPG are focused on this goal, and each recognizes that experimental success depends on the proper isolation of tissue from euthanized animals, careful implementation of surgical procedures and appropriate post-op care. The top priority of the Animal & Instrumentation Core is. to enhance the success of research projects for each investigator. This includes providing a central means for handling animal populations, ensuring proper conditions for surgical use, and maintaining excellent post-op care of animals. By centralizing these tasks, which are common to all projects, the Animal & Instrumentation Core allows investigators to focus on experimental issues and management unique to each project to enhance experimental success.

该计划项目的总体目标是了解调节正常和疾病状态下脑脉管系统的机制。构成该PPG的所有四个项目都集中在这一目标上，并且每个项目都认识到实验成功取决于从安乐死动物中隔离组织，仔细实施手术程序和适当的后护理。动物和仪器核心的重点是。为每个研究者增强研究项目的成功。这包括提供一种处理动物种群的中心手段，确保适当的外科手术条件以及维持对动物的出色后护理。通过集中所有项目共有的任务，动物和仪器核心使研究人员能够专注于每个项目所独有的实验问题和管理，以增强实验成功。