Properties of Ion Channels that Control Secretion

控制分泌的离子通道的特性

• 批准号: 8038532
• 负责人: JOHN J ENYEART
• 金额: $ 22.88万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8038532
• 关键词: Addison' s disease; Adipocytes; Adrenal Cortex; Adrenal Glands; Biochemical; Blood Glucose; Brain; Brain Injuries; Calcium; Cattle; Cell membrane; Cell physiology; Cells; Cessation of life; Chronic stress; Circadian Rhythms; Code; Corticotropin; Coupled; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endocrine; Energy-Generating Resources; Event; Gene Expression; Genes; Genetic Transcription; Goals; Hippocampus (Brain); Hour; Hydrocortisone; Hypoglycemia; Ion Channel; Ions; Knowledge; Learning; Liver; Mediating; Membrane; Memory impairment; Messenger RNA; Molecular; Muscle; Pathology; Pathway interactions; Pattern; Peptides; Physiological; Pituitary Gland; Potassium Channel; Production; Property; Proteins; Psychological Stress; Regulation; Research; Role; Signal Pathway; Signal Transduction; Testing; Transcriptional Activation; Zona Fasciculata; abstracting; design; electrical property; energy balance; hypothalamic-pituitary-adrenal axis; mRNA Stability; novel; patch clamp; public health relevance; response; sugar; voltage

项目成果

Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: properties and modulation by ACTH and AngII.

正常人肾上腺束状带细胞的 Ca2 和 K 通道：ACTH 和 AngII 的特性和调节。

• 发表时间: 2013-08
• 作者: Enyeart, John J;Enyeart, Judith A
• 通讯作者: Enyeart, Judith A

8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanism.

8-苯硫基腺嘌呤通过不依赖于 cAMP 的机制刺激类固醇羟化酶、Cav3.2 Ca2+ 通道的表达以及皮质醇的合成。

• 发表时间: 2011-11
• 作者: Enyeart, Judith A;Liu, Haiyan;Enyeart, John J
• 通讯作者: Enyeart, John J

Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.

肾上腺束状细胞表达 T 型并快速和缓慢激活调节皮质醇分泌的 L 型 Ca2 通道。

• DOI: 10.1152/ajpcell.00002.2015
• 发表时间: 2015-06-01
• 期刊: American journal of physiology. Cell physiology
• 作者: J. J. Enyeart;J. A. Enyeart
• 通讯作者: J. A. Enyeart

Evidence for cAMP-independent bTREK-1 inhibition by ACTH and NPS-ACTH in adrenocortical cells.

肾上腺皮质细胞中 ACTH 和 NPS-ACTH 抑制 cAMP 独立的 bTREK-1 的证据。

• 发表时间: 2012-01-02
• 影响因子: 4.1
• 作者: Enyeart, John J;Liu, Haiyan;Enyeart, Judith A
• 通讯作者: Enyeart, Judith A

Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.

人肾上腺肾小球细胞表达受 ANG II 和 ACTH 抑制的 K2P 和 GIRK 钾通道。

• 发表时间: 2021
• 作者: Enyeart, John J;Enyeart, Judith A
• 通讯作者: Enyeart, Judith A