Penn Center for Innovation in Personalized Breast Screening

宾夕法尼亚大学个性化乳房筛查创新中心

基本信息

批准号：
8223497
负责人：
KATRINA ARMSTRONG
金额：
$ 147.14万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-21 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8223497
关键词：
Address Back Behavior Benefits and Risks Bioinformatics Biological Markers Biometry Biopsy Biostatistics Core Breast Breast Cancer Detection Cancer Detection Characteristics Clinical Collaborations Communication Communities DNA Data Data Coordinating Center Decision Aid Decision Making Digital Mammography Discipline Documentation Electronic Health Record Evaluation Goals Health Health Services Research Healthcare Healthcare Systems Image Individual Internet Intervention Laboratories Leadership Learning Link Malignant Neoplasms Mammography Medical Oncology Medicine Modality Modeling Neighborhoods Outcome Pathology Patient-Centered Care Patients Pennsylvania Performance Policies Policy Maker Population Heterogeneity Primary Health Care Principal Investigator Process Provider Recommendation Records Reporting Research Research Infrastructure Research Personnel Research Project Grants Resources Risk Risk Assessment Risk Factors Role Screening for cancer Screening procedure Site Surveys System Terminology Testing Time Translating Trust Universities Woman Work base biobank cancer genetics cancer imaging cancer risk clinical practice comparative effectiveness computer science cost digital experience health care service utilization imaging modality improved indexing innovation malignant breast neoplasm mortality neoplasm registry new technology novel novel strategies oncology point of care tool

项目摘要

DESCRIPTION (provided by applicant): The ongoing controversy regarding mammography screening recommendations highlights the need for improved performance across the breast cancer screening process. While there is little debate that breast cancer screening can reduce breast cancer mortality, it is also clear that it is time for better approaches to screening that leverage advances in breast imaging modalities, breast cancer risk assessment and patient centered care to achieve better outcomes at lower cost. This application for a Penn Center for Personalized Breast Cancer Screening will advance a personalized breast cancer screening paradigm by developing a new tool (breast complexity index) for predicting individual screening outcomes, evaluating the comparative effectiveness of a new imaging modality (digital breast tomosynthesis) on screening process and outcomes, and developing effective strategies for communicating individual estimates of benefit and risk of alternative screening approaches to better link individualized information to informed patient and provider decision making. In addition to these three highly integrated research projects, the Center will bring together comprehensive screening process and outcome data on a diverse population of 74,000 women who undergo breast cancer screening at 6 sites within the Penn Medicine integrated health network. In addition to clinical, socio demographic and screening data from EMR and screening reporting systems, this Screening Process Documentation Unit will include risk factor and other patient reported information collected through web portal and point of care surveys, screening images, cancer outcomes from state cancer registries and pathology records, patient neighborhood characteristics from the Penn Cartographic Modeling Laboratory, as well as an ongoing DNA biobank. The proposed Center leverages the substantial expertise at Penn in the multiple disciplines needed to advance a personalized screening paradigm (including breast imaging, primary care, communication, computer science, biostatistics, health services research, bioinformatics, medical oncology, and cancer genetics) as well as the commitment of the clinical leadership (including the Center Principal Investigators) to Penn Medicine's role in the evaluation and implementation of such a paradigm. The Center will address questions with immediate scientific, clinical and policy impact and create an infrastructure for continuous learning about the breast cancer screening process and enabling collaboration through the PROSPR network.

描述（由申请人提供）：有关乳房X线摄影筛查建议的持续争议突出了在整个乳腺癌筛查过程中的提高性能的必要性。尽管几乎没有争论说乳腺癌筛查可以降低乳腺癌的死亡率，但也很明显，现在是时候采用更好的方法来进行筛查，以利用乳房成像的方式，乳腺癌风险评估和以患者为中心的护理，以较低的成本取得更好的结果。宾夕法尼亚州个性化乳腺癌筛查中心的应用将通过开发新工具（乳房复杂性指数）来预测个人筛查结果，评估新的成像方式（数字乳房合成性）（数字乳房合成）在筛选过程中，并开发有效的策略，以使个人估算的策略与互联性策略进行更大的依据，从而提高了个性化的乳腺癌筛查范式，以评估新的成像方式（数字乳房合成）的比较有效性决策。除了这三个高度集成的研究项目外，该中心还将汇总74,000名妇女的全面筛查过程和结果数据，这些妇女在Penn Medicine Integrated Health Network的6个地点进行乳腺癌筛查。除了来自EMR和筛查报告系统的临床，社会人口统计和筛查数据外，此筛查过程文档单位还将包括风险因素和其他患者通过Web门户和护理点调查收集的患者报告的信息，筛查图像，州癌症注册表和病理学的癌症结果和病理学记录，宾夕法尼亚州手机模型模型实验室的患者邻里特征，以及On Goughand DNA Biobank。拟议的中心利用了宾夕法尼亚州在宾夕法尼亚州的实质专业知识，以推进个性化的筛查范式（包括乳房成像，初级保健，沟通，计算机科学，生物统计学，卫生服务研究，生物信息学，医学肿瘤学和癌症遗传学），以及对临床领导力的承诺（包括中心的临床医学），并在宾夕法尼亚州的角色中扮演了临床领导力和宾夕法尼亚州的角色。该中心将以直接的科学，临床和政策影响解决问题，并创建一个基础设施，以持续学习有关乳腺癌筛查过程并通过ProSPR网络启用协作。