Prolonged Juvenile State and Juvenile Protective Factors Affect Chronic Diseases

长期青少年状态及青少年保护因素对慢性病的影响

基本信息

批准号：
7533842
负责人：
SHUMEI S SUN
金额：
$ 35.37万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2012-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7533842
关键词：
Adhesions Adolescence Adolescent Adrenal Glands Adult Affect Age Aging Androgens Appearance Biological Markers Birth Blood Vessels Body Composition C-reactive protein Cardiovascular Diseases Cardiovascular system Cell Adhesion Cell Adhesion Molecules Childhood Chronic Disease Data Dehydroepiandrosterone Sulfate Development Development Plans Diagnosis Diastolic blood pressure Fasting Fatty acid glycerol esters Female Freedom Goals Growth Growth and Development function Health Height Homeostasis Insulin Resistance Insulin-Like Growth Factor I Joints Lead Leptin Life Link Lipids Longitudinal Studies Measures Menarche Metabolic Metabolic syndrome Modeling Natural History Non-Insulin-Dependent Diabetes Mellitus Obesity Physiological Plasma Population Population Study Prevalence Prevention approach Protein C Public Health Recommendation Research Risk Factors Testing Time Triglycerides Weight Gain Woman adipokines adiponectin age group bone age boys early childhood fasting plasma glucose girls inflammatory marker male men prevent protective effect sex sexual dimorphism waist circumference

项目摘要

DESCRIPTION (provided by applicant): We will investigate factors involved in the rate of metabolic and cardiovascular aging in men and women in the Fels Longitudinal Study (FLS). Although it is possible to age in good health, in the U.S. population progressive weight gain (Yanovski et al 2000) and an increasing prevalence of the metabolic syndrome are common attributes of aging. The prevalence of adults in the FLS with BMI > 25kg/m2 increases from 30% in the fourth decade of life to 70% in the sixth decade, and the prevalence of the metabolic syndrome increase from 21% to 38% in men and from 14% to 34% in women the same age groups. Tempo of growth and development: We plan to ascertain the influence of a prolonged juvenile state, i.e., a retarded tempo of physiological development, on delaying the onset of the metabolic syndrome, cardiovascular disease (CVD), and type 2 diabetes mellitus (T2DM) later in life. To achieve this goal, we propose to link risk factors for these common but unhealthy features of aging to childhood tempo of physiological development. The tempo of physiological development will be determined in each subject by documenting his or her age at the time of the adiposity rebound; the onset of the pubertal growth spurt; the peak height velocity; menarche; and his or her bone age at each of these milestones. The temporal range of these milestones varies from 5 years for the adiposity rebound to nearly 8 years for menarche, and bone age may lag behind or jump ahead of chronological age by as much as 4.5 years in either direction. We plan to accomplish our objectives using long-term serial data collected from birth over periods as long as 75 years in 361 adult males and 354 adult females in the FLS. Juvenile protective factors: We also propose to examine levels of biomarkers measured in childhood and adolescence that are associated with a delayed onset of the metabolic syndrome, CVD, and T2DM. Such delays may be caused by the persistence of juvenile levels of protective factors into adulthood, or else by the persistence into adulthood of effects initiated by such factors in childhood. The biomarkers we will study include body composition, lipid profiles, adipokines, inflammatory markers, insulin resistance, insulin-like growth factor-1 (IGF-1), and adrenal androgens. We plan to identify which of these biomarkers measured during childhood and adolescence act to delay the onset of the metabolic syndrome, CVD, and T2DM and could be considered as juvenile protective factors. The proposed analysis of serial data collected over decades should reveal the natural history of the onset of the metabolic syndrome, CVD, and T2DM in relation to the tempo of growth and development during the first two decades of life and in relation to levels of biomarkers during childhood and adolescence that could be considered to be juvenile protective factors. We are examining features of childhood that prevent or delay the onset of unhealthy aspects of aging.

描述（由申请人提供）：我们将在费尔斯纵向研究（FLS）中调查与男性和女性代谢和心血管衰老速度相关的因素。尽管健康地衰老是可能的，但在美国人口中，体重逐渐增加（Yanovski et al 2000）和代谢综合征患病率的增加是衰老的常见特征。 FLS 中 BMI > 25kg/m2 的成年人的患病率从 40 岁的 30% 增加到 60 岁的 70%，代谢综合征的患病率从男性的 21% 增加到 38%，从 14 岁增加到 14%。同年龄段女性中的 % 至 34%。生长和发育速度：我们计划确定长期幼年状态，即生理发育速度迟缓，对延缓代谢综合征、心血管疾病 (CVD) 和 2 型糖尿病 (T2DM) 发病的影响在以后的生活中。为了实现这一目标，我们建议将这些常见但不健康的衰老特征的风险因素与儿童时期的生理发育节奏联系起来。通过记录肥胖反弹时的年龄来确定每个受试者的生理发育节奏；青春期生长突增的开始；峰值高度速度；初潮; 以及他或她在每个里程碑的骨龄。这些里程碑的时间范围从肥胖反弹的 5 年到初潮的近 8 年不等，骨龄可能会滞后或超前实际年龄 4.5 年。我们计划使用 FLS 中 361 名成年男性和 354 名成年女性从出生起长达 75 年的长期序列数据来实现我们的目标。青少年保护因素：我们还建议检查儿童期和青春期测量的与代谢综合征、CVD 和 T2DM 延迟发作相关的生物标志物水平。这种延迟可能是由于青少年时期的保护性因素水平持续到成年期所致，或者是由于这些因素在童年时期引发的影响持续到成年期所致。我们将研究的生物标志物包括身体成分、血脂、脂肪因子、炎症标志物、胰岛素抵抗、胰岛素样生长因子-1 (IGF-1) 和肾上腺雄激素。我们计划确定哪些在儿童期和青春期测量的生物标志物能够延缓代谢综合征、CVD 和 T2DM 的发作，并可被视为青少年保护因素。对几十年来收集的连续数据进行分析，应能揭示代谢综合征、CVD 和 T2DM 发病的自然史，与生命前 20 年的生长和发育节奏以及生命期间生物标志物水平的关系。童年和青春期可被视为青少年保护因素。我们正在研究童年时期的特征，这些特征可以预防或延缓衰老过程中不健康方面的发生。