2011-2013 Metals in Biology GRC and Bioinorganic GRS

2011-2013 生物GRC和生物无机GRS中的金属

• 批准号: 8197758
• 负责人: WILLIAM B Tolman
• 金额: $ 0.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197758
• 关键词: Alzheimer' s Disease; Anabolism; Antibiotics; Bioinorganic Chemistry; Biology; Chemicals; Chemistry; Collaborations; Communities; DNA; Data; Development; Diagnostic; Discipline; Disease; Drug Delivery Systems; Ensure; Enzymes; Fostering; Funding; Future; Hormones; Ions; Knowledge Discovery; Leukotrienes; Malignant Neoplasms; Metals; Modeling; Molecular; Nature; Neurotransmitters; Parents; Parkinson Disease; Participant; Pathway interactions; Performance; Physics; Play; Postdoctoral Fellow; Request for Proposals; Research; Research Personnel; Role; Running; Scientist; Steroids; Students; Training; biological systems; graduate student; improved; lectures; meetings; metalloenzyme; multidisciplinary; organizational structure; public health relevance; success; symposium; tool

DESCRIPTION (provided by applicant): This proposal requests funds to support the Metals in Biology Gordon Research Conference (MIB GRC) in Jan-Feb, 2011-2013, and the associated Graduate Research Seminar in Bioinorganic Chemistry (GRS) in February, 2011-2013. The MIB GRC provides the principal forum for the discussion of research at the forefront of bioinorganic chemistry. It is the core meeting for the field, is a 'flagship', leading GRC with an 85% performance rating (2008 data), and is consistently oversubscribed even though it has met consistently since 1962. The GRS was established in 1996 in order to provide a forum for graduate students and postdocs to participate in a meeting that overlaps with the "parent" MIB GRC (for one evening), yet also runs independently. This organizational structure ensures that the students and postdocs interact with leading researchers while developing their own sense of community, providing a means for future leaders of the field to emerge. The two and a half day GRS is organized by young investigators with the support of leading scientists from the associated GRC. A central theme of both meetings is the need to understand the critical role that metal ions play in diverse biological systems. Specifically, metal ions are critical for the function of over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. The molecular-level details regarding metalloenzyme function emerge from multiple complementary lines of study, at the interface of chemistry, biology, and physics. A thorough understanding of metallobiochemistry is critical to the development of potential diagnostic tools and drug targets for the treatment of diseases such as Alzheimer's, Parkinson's, and cancer. Discussion of these issues in formal lectures and informal interactions in the unique Gordon Research Conference format effectively disseminates knowledge of discoveries at the forefront of research in the field, fosters collaborations, and improves the cohesiveness of the field, notwithstanding its highly multidisciplinary nature. PUBLIC HEALTH RELEVANCE: A central theme of the meetings is the need to understand the critical role that metal ions play in diverse biological systems. Specifically, metal ions are critical for the function of over one third of all enzymes, and are involved in a number of important biosynthetic pathways including the conversion of electrochemical to chemical energy, and the biosynthesis of antibiotics, DNA, neurotransmitters, steroids, leukotrienes, and hormones. A thorough understanding of metallobiochemistry is critical to the development of potential diagnostic tools and drug targets for the treatment of diseases such as Alzheimer's, Parkinson's, and cancer.

描述（由申请人提供）：该提案要求资金在2011年至2013年1月 - FEB的生物学戈登研究会议（MIB GRC）以及2011年2月在2011年2月的生物促进化学（GRS）的研究生研究研讨会。 MIB GRC提供了在生物无机化学最前沿的研究讨论的主要论坛。它是该领域的核心会议，是一个“旗舰”，领先GRC的性能等级为85％（2008年数据），即使自1962年以来一直在始终相遇，也始终如一地超额认购。该GRS于1996年成立于1996年，以便为研究生和博士提供一个论坛，以便与“同时与“父母”一晚的跑步群体一起参加“ Mib” Mib GRC（以备用“ Mib”）（以“一位” Mib（一个晚上），以供“ Mib”（Mib GRC）（以“ Mib”（Mib Grc））（一个晚上）（以“ Mib”（Mib Grc））（以“ Mib”（Mib Grc）（一对一），以供“ Mib”（Mib Grc）（以“ Mib”（Mib Grc）为独立），以便为“ Mib”（Mib Grc）（又有一个晚上）。这种组织结构可确保学生和博士后与领先的研究人员互动，同时发展自己的社区意识，为未来的领导者出现一种手段。两天半的GRS是由年轻的研究人员组织的，在相关GRC的主要科学家的支持下。 两次会议的一个核心主题是需要了解金属离子在各种生物系统中的关键作用。具体而言，金属离子对于所有酶的三分之一以上的功能至关重要，并且参与了许多重要的生物合成途径，包括电化学向化学能的转化以及抗生素，DNA，神经递质，神经固醇，类固醇，白细胞和激素的生物合成。关于金属酶功能的分子级详细信息来自化学，生物学和物理学的界面，从多个互补的研究线中出现。对金属生物化学的透彻理解对于开发潜在的诊断工具和药物目标是治疗诸如阿尔茨海默氏症，帕金森氏症和癌症等疾病的药物目标。在独特的戈登研究会议格式中对这些问题的讨论和非正式互动有效地传播了在该领域研究的最前沿，促进合作的知识，并提高了该领域的凝聚力，尽管其高度多学科的性质。 公共卫生相关性：会议的一个核心主题是需要了解金属离子在各种生物系统中所起的关键作用。具体而言，金属离子对于所有酶的三分之一以上的功能至关重要，并且参与了许多重要的生物合成途径，包括电化学向化学能的转化以及抗生素，DNA，神经递质，神经固醇，类固醇，白细胞和激素的生物合成。对金属生物化学的透彻理解对于开发潜在的诊断工具和药物目标是治疗诸如阿尔茨海默氏症，帕金森氏症和癌症等疾病的药物目标。