A Whole Systems Approach to the Study of Ayurveda for Cancer Survivorship

阿育吠陀癌症生存研究的整体系统方法

• 批准号: 8248787
• 负责人: Anand Dhruva
• 金额: $ 12.83万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8248787
• 关键词: Accounting; Acupuncture procedure; Address; Aftercare; Anxiety; Applications Grants; Attention; Behavioral Research; Biological Factors; Botanicals; California; Cancer Patient; Cancer Survivor; Cancer Survivorship; Caring; Chinese Traditional Medicine; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Communities; Complementary and alternative medicine; Complex; Control Groups; Controlled Study; Data; Data Analyses; Data Collection; Diagnosis; Disease remission; Enrollment; Equilibrium; European Organization for Research and Treatment of Cancer; Evaluation; Fatigue; Foundations; Future; Goals; HIV; Healed; Health; Healthcare; Hematologist; Individual; Institute of Medicine (U.S.); Instruction; Integrative Medicine; Interleukin-6; Intervention; Interview; Investigation; K-Series Research Career Programs; Lead; Learning; Life Style; Malignant Neoplasms; Manuals; Medical Oncologist; Medicine; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Modality; Modeling; Oncologist; Outcome; Outcome Measure; Patient Self-Report; Patients; Persons; Pilot Projects; Placebo Effect; Preventive Intervention; Qualitative Methods; Qualitative Research; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Reporting; Reproducibility; Research; Research Methodology; Research Personnel; Residual state; Sample Size; Sampling; San Francisco; Sleeplessness; Surveys; Symptoms; System; Techniques; Testing; Therapeutic Touch; Time; Treatment Efficacy; Universities; Videotape; Yoga; anakinra; arm; ayurveda; base; cancer care; cancer therapy; career; design; experience; healing; improved; malignant breast neoplasm; nutrition; oncology; patient population; programs; prospective; psychosocial; symptom management; treatment planning; virtual

This is an application for a K23 award for Dr. Anand Dhruva, a medical oncologist/hematologist at the University of California, San Francisco. Dr. Dhruva is establishing himself as a young investigator in complementary and alternative medicine (CAM) and cancer symptom management. This K23 will provide Dr. Dhruva with the support necessary to accomplish the following goals: (1) to develop into an Independent clinical investigator focusing on the rigorous study and successful integration of CAM modalities into conventional oncology care; (2) to learn and apply compatible research methods for the study of whole systems of medicine, with focused expertise in the study of the application of Ayurveda to the oncology setting; and (3) to learn and apply advanced clinical research and qualitative methods in clinical studies. To achieve these goals, Dr. Dhruva has assembled a mentoring team comprised of primary mentor, Dr. Frederick Hecht, Director of Research at the Osher Center for Integrative Medicine, who conducts clinical investigations in CAM and HIV, and three co-mentors: Dr. Christine Miaskowski, an expert in the study of cancer-related symptoms and quality of life; Dr. Donald Abrams, an oncologist who focuses on integrative oncology; and Dr. Shelley Adler, an expert in qualitative research. Despite achieving remission or cure, many cancer survivors discover that the residual symptoms due to the cancer and/or the treatment of the cancer to be difficult, disabling, and impair quality of life. Whole systems approaches to health, such as Ayurveda, have potential benefits for improving quality of life and symptoms in cancer survivors. Complex, individualized interventions, such as those used in Ayurveda, are currently being studied using the technique of "manualization," in which a study manual is utilized to balance the competing concerns of reproducibility and ecological validity. Dr. Dhruva's research will focus on developing a manualized Ayurvedic approach to improve cancer survivor quality of life and symptoms (Aim 1) and then conducting a pilot randomized controlled trial to assess feasibility and obtain preliminary estimates of efficacy of a manualized Ayurvedic approach to improve quality of life and symptoms among breast cancer survivors (Aim 2). This research will form the basis for a larger randomized controlled trial of Ayurveda (using the manualized approach developed in this K award) that will investigate the efficacy of Ayurveda to improve quality of life and symptoms among breast cancer survivors, which will be proposed in a subsequent ROl grant application. RELEVANCE (See instructions): With increasing numbers of cancer survivors, improving understanding of effective and safe ways to improve quality of life and residual symptoms is important. Given the widespread use of CAM, more evidence from rigorously conducted studies is needed to guide its successful integration into modern healthcare.

这是 Anand Dhruva 博士的 K23 奖项申请，他是该医院的肿瘤内科医师/血液学家 加州大学旧金山分校。 Dhruva 博士正在将自己定位为一名年轻的调查员 补充和替代医学（CAM）和癌症症状管理。这款 K23 将提供 Dhruva 博士获得实现以下目标所需的支持：(1) 发展成为独立的 临床研究者专注于 CAM 模式的严格研究和成功整合 传统肿瘤护理； (2)学习并运用兼容的研究方法进行整体研究 医学系统，专注于阿育吠陀在肿瘤学应用研究的专业知识 环境; (3)学习并应用先进的临床研究和临床研究中的定性方法。到 为了实现这些目标，Dhruva 博士组建了一个由主要导师 Dr. Dhruva 博士组成的指导团队。 弗雷德里克·赫克特 (Frederick Hecht)，奥舍整合医学中心研究主任，负责临床研究 CAM 和 HIV 的研究，以及三位共同导师：Christine Miaskowski 博士，研究专家 癌症相关症状和生活质量； Donald Abrams 博士是一位专注于综合治疗的肿瘤学家 肿瘤学；以及定性研究专家 Shelley Adler 博士。 尽管实现了缓解或治愈，许多癌症幸存者发现由于以下原因而残留的症状 癌症和/或癌症的治疗是困难的、致残的和损害生活质量的。所有的 系统的健康方法，例如阿育吠陀，对于改善生活质量和 癌症幸存者的症状。复杂的、个性化的干预措施，例如阿育吠陀中使用的干预措施， 目前正在研究使用“手动化”技术，其中利用学习手册来平衡 可重复性和生态有效性的相互竞争的关注点。 Dhruva 博士的研究重点是 开发手动阿育吠陀方法来改善癌症幸存者的生活质量和症状（目标 1）然后进行试点随机对照试验来评估可行性并获得初步结果 手动阿育吠陀方法改善生活质量和症状的功效估计 乳腺癌幸存者（目标 2）。这项研究将为更大规模的随机对照试验奠定基础 阿育吠陀（使用本 K 奖中开发的手动方法）将研究以下功效： 阿育吠陀旨在改善乳腺癌幸存者的生活质量和症状，这将在 随后的 ROI 拨款申请。 相关性（参见说明）： 随着癌症幸存者数量的不断增加，人们对有效且安全的改善方法的了解不断加深 生活质量和残留症状很重要。鉴于 CAM 的广泛使用，更多证据来自 需要进行严格的研究来指导其成功融入现代医疗保健。