2012 Biology of Acute Respiratory Infection Gordon Research Conference

2012年急性呼吸道感染生物学戈登研究会议

• 批准号: 8249190
• 负责人: Alice S Prince
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249190
• 关键词: 2 year old; AIDS/HIV problem; Acute; Acute respiratory infection; Address; Area; Bacteria; Bacterial Pneumonia; Biology; Cessation of life; Child; Collaborations; Communities; Data; Disabled Persons; Epidemiology; Epithelial; Europe; Fostering; Funding; Goals; Healthcare; Hospitalization; Host Defense; Human; Immune; Immune response; Immunologics; Immunologist; Immunology; Infection; Influenza; Lead; Lipoxins; Lung; Malignant Neoplasms; Medical; Modeling; Morbidity - disease rate; Mucosal Immune Responses; Mycoplasma pneumoniae; Natural Immunity; Organism; Pathogenesis; Pathology; Pertussis; Pneumococcal vaccine; Pneumonia; Postdoctoral Fellow; Prevention; Prevention strategy; Public Health; Reagent; Request for Applications; Research; Research Personnel; Respiratory Tract Infections; Role; Running; Scientist; Signal Transduction; Staging; Staphylococcus aureus; Streptococcus pneumoniae; Technology; Thinking; Time; Underrepresented Minority; Viral Pathogenesis; Virus; Virus Diseases; Woman; Work; adaptive immunity; career; cost; disorder prevention; experience; fungus; graduate student; influenza virus vaccine; interest; meetings; methicillin resistant Staphylococcus aureus; microbial; mortality; novel strategies; pathogen; peer; posters; response; symposium; vaccine development

DESCRIPTION: This application requests funding to partially support the third meeting of the Gordon Research Conference on the Biology of Acute Respiratory Infection. This meeting will be held in Ventura, CA March 11-16, 2012 and we expect 110 - 150 scientists to participate. The overarching goal of this multi-disciplinary conference is to provide a setting to present and discuss outstanding research in the area of acute lung infection. As the diverse pathogens that infect the lung activate a limited number of conserved immunologic responses, there is a great deal of information that can be shared by colleagues working in and by colleagues who study different pathogens. General principles of vaccine development, particularly the activation of local immune protection are highly relevant to many different types of pulmonary infection. The meeting will run for 4 1/2 days leading off with presentations each morning dealing with general topics in innate immunity relevant to diverse types of lung infection. Sessions devoted to specific pathogens will be held in morning and evening sessions, each led by an experienced discussion leader, often a scientist who has presented their own work at previous meetings. Topics will include major causes of bacterial pneumonia, Streptococcus pneumoniae, Staphylococcus aureus (especially MRSA) Mycoplasma pneumoniae and pertussis. Sessions focusing upon viral pathogenesis and prevention will be held focusing on influenza, RSV and mixed bacterial/viral infection. Several talks will address the host response to infection; the participation of lipoxins and resolvins, the role of epithelial signaling in host defense, and the recruitment of PMNs to the lung will be included. Afternoon poster sessions will provide an informal venue to discuss work-in progress and enable graduate students and post-docs to meet with various luminaries in their field of interest as well as their peers. At all stages of speaker invitation and recruitment of attendees we have made every effort to encourage participation by women, underrepresented minorities and people with disabilities. As pulmonary infection is a leading cause of mortality in the USA and worldwide this conference is highly relevant to public health and will potentially foster novel approaches to disease prevention and vaccine development. PUBLIC HEALTH RELEVANCE: Acute lung infections are a major cause of morbidity and mortality, associated with a greater number of deaths each year in the USA than HIV/AIDS and cancer combined. The health care associated costs of community-acquired pneumonia in 2007 exceeded 2 billion dollars/year in Europe alone, despite the availability of pneumococcal and influenza vaccines. The cost of RSV hospitalizations for children under 2 years of age in the US exceeds 384 million dollars per year. Although many different types of pathogens infect the lung, there are conserved mucosal immune responses to these infections. The purpose of this conference is to provide a forum for investigators who study acute lung infections to better understand microbial pathogenesis and the intricacies of the immune responses evoked which cause much pathology. This Gordon research Conference will provide an opportunity to share new hypotheses, discuss novel approaches and establish collaborations to better understand the pathogenesis of lung infection and hopefully develop better strategies for prevention and treatment.

描述： 该申请要求资金部分支持戈登呼吸道感染生物学研究会议的第三次会议。这次会议将于2012年3月11日至16日在加利福尼亚州的文图拉举行，我们预计110-150名科学家将参加。这次多学科会议的总体目标是提供一个环境，以展示和讨论急性肺部感染领域的杰出研究。随着感染肺部的多种病原体激活了有限的保守免疫反应，因此在研究不同病原体的同事中，同事和同事可以共享大量信息。疫苗发育的一般原理，特别是局部免疫保护的激活与许多不同类型的肺部感染高度相关。这次会议将在每天早上进行4 1/2天的开展，以涉及与各种肺部感染相关的先天免疫的一般主题。专门用于特定的会议 病原体将在早晨和晚上举行，每个会议由经验丰富的讨论负责人领导，通常是一位在以前的会议上展示自己的工作的科学家。主题将包括细菌性肺炎，肺炎链球菌，金黄色葡萄球菌（尤其是MRSA）肺炎和百日咳的主要原因。关注病毒发病机理和预防的会议将集中在流感，RSV和混合细菌/病毒感染上。几次谈判将解决宿主对感染的反应；脂毒素和溶质素的参与，上皮信号在宿主防御中的作用以及将PMN募集到肺中的作用将包括在内。下午的海报会议将提供一个非正式的场所，讨论工作进步，并使研究生和毕业后能够与他们感兴趣的各种名人以及同龄人会面。在演讲者邀请和招募与会者的所有阶段，我们已尽一切努力鼓励妇女，代表性不足的少数民族和残疾人参与。由于肺部感染是美国死亡率的主要原因，并且在全球范围内，本次会议与公共卫生高度相关，并有可能促进预防疾病和疫苗开发的新颖方法。 公共卫生相关性： 急性肺部感染是发病率和死亡率的主要原因，与艾滋病毒/艾滋病和癌症相比，美国每年的死亡人数更多。尽管有肺炎球菌和流感疫苗，但2007年，2007年社区获得的肺炎的医疗保健相关费用超过了20亿美元/年。美国2岁以下儿童的RSV住院费用每年超过3.84亿美元。尽管许多不同类型的病原体感染了肺，但对这些感染有保守的粘膜免疫反应。这次会议的目的是为研究急性肺部感染的研究人员提供一个论坛，以更好地了解微生物发病机理以及引起多种病理学的免疫反应的复杂性。这次戈登研究会议将提供一个分享新假设，讨论新方法并建立合作以更好地了解肺部感染的发病机理的机会，并希望制定更好的预防和治疗策略。