Stress Related Mechanisms of Hypertension Risk in Youth

青少年高血压风险的压力相关机制

• 批准号: 8058686
• 负责人: GREGORY ALAN HARSHFIELD
• 金额: $ 211.11万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8058686
• 关键词: Stress; Related; Mechanisms; Hypertension; Risk

DESCRIPTION (provided by applicant): This program project renewal application is an integrated multidisciplinary program including four closely related projects examining the roles of stress, lifestyle behaviors and genetic predisposition in the development of preclinical measures of essential hypertension. New to the renewal application will be the incorporation of adiposity as a mediating factor into our gene/environment interaction model. Four vasoactive pathways will be examined which may link impaired sodium regulation during stress and exaggerated cardiovascular reactivity to stress to the development of preclinical measures of hypertension. These pathways are the sympathetic nervous system, the renin-angiotensin-aldosterone system, the endothelial system, and the hypothalamic-pituitary-adrenal axis. Specifically, Projects 1 and 4 will focus on the role of the renin-angiotensin-aldosterone system in human and animal models of stress-induced salt sensitive hypertension. Projects 2 (human) and 3 (animal) will continue in the evaluation of blood pressure hyper-reactivity. Project 2 will continue to evaluate this model in a cohort of subjects with a family history of hypertension that will have been continuously evaluated for 22 years. Also, new to this application will be evaluation of the hypothalamic-pituitary-adrenal axis. Project 3 will use air jet stress in Dahl salt-sensitive rats to examine acute changes in endothelin and oxidative stress. All four projects will examine a potential mediating role of increased adiposity. In addition, each of these four projects will be supported by an Administrative (Core A), Bioassay (Core B), Biomedical (Core C), and Data Management and Statistics (Core D) cores.

描述（由申请人提供）： 该计划项目更新应用程序是一个综合的多学科计划，包括四个密切相关的项目，研究压力，生活方式行为和遗传倾向在开发基本高血压的临床前测量中的作用。续签应用的新手将是将肥胖作为中介因子纳入我们的基因/环境相互作用模型。将检查四个血管活性途径，这可能会将压力期间钠调节受损和夸大的心血管反应性与压力与高血压测量的发展联系起来。 这些途径是交感神经系统，肾素 - 血管紧张素 - 醛固酮系统，内皮系统和下丘脑 - 垂体 - 肾上腺轴。具体而言，项目1和4将重点关注肾素 - 血管紧张素 - 醛固酮系统在应激诱导的盐敏感高血压的人类和动物模型中的作用。项目2（人）和3（动物）将继续评估血压高反应性。项目2将继续在具有高血压家族史的一系列受试者中评估该模型，这些史将不断评估22年。同样，该应用程序的新手将是对下丘脑 - 垂体 - 肾上腺轴的评估。项目3将在DAHL盐敏感大鼠中使用空气胁迫检查内皮素和氧化应激的急性变化。这四个项目将检查肥胖增加的潜在中介作用。此外，这四个项目中的每个项目都将得到行政（核心A），生物测定（核心B），生物医学（核心C）以及数据管理和统计（核心D）内核的支持。