4th ASM Conference on Prokaryotic Cell Biology and Development

第四届 ASM 原核细胞生物学与发育会议

• 批准号: 8319208
• 负责人: SUSAN S GOLDEN
• 金额: $ 0.5万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319208
• 关键词: Address; American; Anabolism; Anti-Bacterial Agents; Antibiotic Resistance; Area; Bacillus subtilis; Behavior; Biochemical; Biochemistry; Biological; Biological Models; Canada; Caulobacter crescentus; Cell Cycle; Cell Cycle Regulation; Cell Differentiation process; Cell Polarity; Cell Shape; Cell Wall; Cell division; Cell physiology; Cells; Cellular Structures; Cellular biology; Collaborations; Commit; Communities; Coupling; Cytoskeleton; Development; Developmental Biology; Developmental Process; Drug Delivery Systems; Escherichia coli; Faculty; Feedback; Female; Fostering; Funding; Gene Expression; Gene Proteins; Goals; Heart; Imaging technology; Individual; International; Investigation; Knowledge; Maintenance; Metabolism; Methodology; Microbial Biofilms; Microbiology; Microscopy; Mind; Modeling; Molecular; Molecular Genetics; Morphogenesis; Myxococcus xanthus; Oral; Organelles; Organism; Participant; Pharmaceutical Preparations; Postdoctoral Fellow; Prevalence; Prokaryotic Cells; Property; Regulation; Research; Research Activity; Research Personnel; Resolution; Scientist; Signal Transduction; Signal Transduction Pathway; Societies; Streptomyces coelicolor; Structural Biologist; Structure; Study models; System; Systems Biology; Technology; Theoretical model; Thinking; Time; Virulence; Whole Organism; Work; abstracting; antimicrobial; career; cell behavior; cell envelope; cell motility; cellular imaging; experience; graduate student; insight; intercellular communication; interdisciplinary approach; interdisciplinary collaboration; interest; meetings; member; next generation; novel; novel strategies; pathogen; structural biology; symposium; three dimensional structure; unpublished works

DESCRIPTION (provided by applicant): Over the last decade key insights have been gained into the fundamental mechanisms underlying the internal organization of prokaryotic cells and how this ties in with prokaryotic development and multicellular behavior. In particular, advances in prokaryotic cell biology have led to fundamental insights in our understanding of essential cell structures including the cell division apparatus, the cytoskeleton, the cell wall, and structures involved in bacterial motility. Similarly, important insights have been gained into how cells organize and interact to differentiate and form biofilms by means of sophisticated intercellular communication systems and intracellular signal transduction pathways. Because cell differentiation involves a reorganization of cell shape, division, metabolism and gene expression, the investigation of differentiating prokaryotic cells is providing important insights into these fundamental cellular properties. These insights into cell function are vitally important because of the increasing prevalence of antibiotic resistant pathogens. Developing the next generation of antibacterial drugs will require new thinking that takes advantage of knowledge derived from our growing understanding of the fundamental mechanisms of prokaryotic cell function, interactions and development. For example, the cell division apparatus, the cytoskeleton, the cell wall, and structures involved in bacterial motility are high priority drug targets. Furthermore, the cell-cell signaling mechanisms that coordinate cell behavior are vitally important virulence determinants and disrupting these signaling networks is an outstanding strategy for the development of novel antimicrobial therapies. This subject matter is at the heart of this conference. The central goals of this conference are to bring together researchers using the most sophisticated approaches to address the most important questions in the field of prokaryotic cell and developmental biology, and provide a forum for them to share ideas. Thus, presentations are planned that focus on basic biochemical, molecular genetics, and cell biological approaches to fundamental questions - research at the level of one or a small number of genes and proteins - as well as systems-level research uncovering regulatory networks in whole organisms and communities of organisms. The scientists who have committed to speak at this conference are international leaders in their fields. This unique access to the best minds in this field will provide graduate students and postdoctoral fellows with an inspiring and very stimulating educational experience. The core subject matter involves five widely and successfully studied systems: Escherichia coli (cell division, cytoskeletal structures, cell wall biosynthesis), Bacillus subtilis (cell cycle regulation, cytoskeletal structures, development, biofilm formation, cell wall biosynthesis), Caulobacter crescentus (cell cycle, differentiation, polarity, cytoskeletal structures, cell wall biosynthesis), Streptomyces coelicolor (multicellular development, differentiation, cell cycle regulation, intercellular communication) and Myxococcus xanthus (multicellular development, differentiation, intercellular communication, polarity). We expect these five organisms to constitute a core of the meeting; however, emerging model systems and opportunistic pathogens will also be included. PUBLIC HEALTH RELEVANCE: One of the major discoveries in microbiology in the last two decades is the finding that prokaryotic cells are spatially highly organized and that this organization closely ties in with prokaryotic development. Therefore, prokaryotic cell biology and development is recognized as an important aspect of microbiology and is an area of intense research activity. Research in this area encompasses microbiology, molecular genetics, cell biology, biochemistry, structural biology, system biology, and theoretical modeling. This ASM-sponsored conference entitled "Prokaryotic Cell Biology and Development" is dedicated to exploring the state-of-the-art in this critical field. The aims of this conference are i) to promot information sharing that will encourage the development of new research directions by bringing together scientists working in different areas and on diverse organisms, ii) to promote junior investigators in the field and promote diversity within the research community, and iii) to provide a format for collegial interactions and discussion between scientists in different fields.

描述（由申请人提供）：在过去的十年中，主要的见解已获得了基本的原核病细胞内部组织的基本机制，以及这如何与原核发展和多细胞行为联系在一起。特别是，实质性细胞生物学的进步导致了我们对必需细胞的理解的基本见解 包括细胞分裂设备，细胞骨架，细胞壁以及涉及细菌运动的结构在内的结构。同样，通过复杂的细胞间通信系统和细胞内信号转导途径，细胞如何组织和相互作用以分化和形成生物膜。由于细胞分化涉及细胞形状，分裂，代谢和基因表达的重组，因此分化原核细胞的研究正在为这些基本细胞特性提供重要的见解。这些对细胞功能的见解至关重要 由于抗生素耐药病原体的患病率增加。开发下一代抗菌药物将需要新的思维，这利用我们对原核生物细胞功能，相互作用和发育的基本机制的了解所带来的知识。例如，细胞分裂设备，细胞骨架，细胞壁以及参与细菌运动的结构是高优先药物靶标。此外，将细胞行为配置为重要的毒力决定因素并破坏这些信号网络的细胞细胞信号传导机制是开发新型抗菌疗法的杰出策略。这个主题是这次会议的核心。这次会议的核心目标是使用最复杂的方法将研究人员汇集在一起​​，以解决原核生物细胞和发育生物学领域中最重要的问题，并为他们提供一个论坛来分享思想。因此，计划的介绍集中在基本的生物化学，分子遗传学以及细胞生物学方法上，用于基本问题 - 在一个或少数基因和蛋白质水平上的研究 - 以及系统级别的研究，揭示了整个生物体和社区中的调节网络。致力于在这次会议上发言的科学家是他们领域的国际领导人。这种在该领域的最佳思想的独特访问将为研究生和博士后研究员提供鼓舞人心且令人振奋的教育经验。 The core subject matter involves five widely and successfully studied systems: Escherichia coli (cell division, cytoskeletal structures, cell wall biosynthesis), Bacillus subtilis (cell cycle regulation, cytoskeletal structures, development, biofilm formation, cell wall biosynthesis), Caulobacter crescentus (cell cycle, differentiation, polarity, cytoskeletal structures, cell wall生物合成），链霉菌（多细胞发育，分化，细胞周期调节，细胞间通讯）和xanthus粘菌球（多细胞发育，分化，细胞间通信，极性）。我们希望这五种生物构成会议的核心。但是，还将包括新兴模型系统和机会性病原体。 公共卫生相关性：过去二十年来微生物学的主要发现之一是，原核生物细胞在空间上是有组织的，并且该组织与原核发展密切相关。因此，原核生物细胞的生物学和发育被认为是微生物学的重要方面，并且是强烈的研究活动的领域。该领域的研究包括微生物学，分子遗传学，细胞生物学，生物化学，结构生物学，系统生物学和理论模型。这次由ASM赞助的会议题为“原核细胞生物学和开发”致力于探索这个关键领域的最先进。这次会议的目的是i）促进信息共享，以通过在不同地区和不同生物上工作的科学家聚集在一起，以鼓励开发新的研究方向，ii）促进该领域的初级研究人员，并促进研究社区内的多样性，以及III），以提供） 不同领域的科学家之间的合作互动和讨论的格式。