Patient-Oriented Research and Mentoring in the Translational Neurobiology/Genetic

转化神经生物学/遗传学中以患者为导向的研究和指导

• 批准号: 8233537
• 负责人: ROBERT T MALISON
• 金额: $ 16.54万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8233537
• 关键词: Acetaldehyde; Adverse effects; Alcohol consumption; Alcohols; Area; Attenuated; Award; Chairperson; Clinical; Clinical Research; Cocaine; Cocaine Abuse; Cocaine Dependence; Comorbidity; Complex; Data; Development; Development Plans; Disease; Disulfiram; Doctor of Medicine; Dopamine-beta-monooxygenase; Drug Addiction; Educational Curriculum; Educational process of instructing; Epidemiology; Euphoria; Extramural Activities; Flushing; Foundations; Funding; Genes; Genetic; Genetic Variation; Goals; Grant; Immersion Investigative Technique; Individual; Industry; Judgment; Lead; Mentors; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; National Institute of Drug Abuse; Nausea and Vomiting; Neurobiology; Opiate Addiction; Peer Review; Pharmaceutical Preparations; Pharmacogenetics; Population; Preceptorship; Principal Investigator; Production; Productivity; Psychiatry; Psychopharmacology; Psychostimulant dependence; Publications; Qualifying; Reliance; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Self Administration; Substance Addiction; Substance abuse problem; Syndrome; Time; Training; Withdrawal; addiction; alcoholism therapy; aldehyde dehydrogenases; base; career development; clinically relevant; cocaethylene; cocaine use; design; expiration; improved; meetings; mental health center; neuroimaging; patient oriented; patient oriented research; professor; programs; research study; skills; symposium; trait

DESCRIPTION (provided by applicant): MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEARCH (K24) This K24 application seeks support that is essential for the candidate's continued career development as an independent, patient-oriented researcher and mentor. The candidate has attained considerable expertise in the clinical neurobiology of stimulant addiction, employing convergent methodologies (neuroimaging, psychopharmacology, drug self-administration, and most recently, genetics). He has demonstrated considerable productivity as evidenced by peer-reviewed publications (both as principal and senior author) and extramural research support (6 R01s, 1 R03, 2 research training grants, 2 center grant sections, scientific co-directorship of a major center, and 6 foundation grant awards). However, expiration of the candidate's K02 has resulted in him having to assume major (>50%) clinical and administrative responsibilities unrelated to this research. This occurs at a critical time, as this new area (genetics) requires highly specialized training and increasing reliance of trainees on this expertise. Thus, the K24 award is vital for sustaining the candidate's patient-oriented research and research-related mentoring activates. Moreover, the award will enable the candidate's immersion in an area of rapid change, thereby facilitating his mastery of newly independent research skills in substance dependence genetics. Justification for the award is provided by a comprehensive 5-year career development plan which 1) allows the candidate to enhance skills in the genetics / pharmacogenetics of complex traits, and 2) enables the candidate to continue his mentoring of beginning investigators in clinical research. Intensive training is provided by an integrated curriculum of intramural coursework, extramural didactics, individualized preceptorships, interactive symposia, and research-related organizational meetings. Two representative research studies are presented in detail - including 1) a study of drug dependence in an isolated population (active) and 2) a pharmacogenetic study of cocaine, disulfiram and genetic variation (C-1021T) in the gene for dopamine beta-hydroxylase (DBH).

描述（由申请人提供）：以患者为导向的研究（K24）的中级护理研究者奖（K24）寻求支持，这对于候选人作为独立的，注重患者的研究人员和导师的职业发展至关重要。该候选人在刺激性成瘾的临床神经生物学方面具有丰富的专业知识，采用收敛方法（神经影像学，心理药理学，药物自我管理，以及最近的遗传学）。他已经证明了相当大的生产力，可以通过同行评审的出版物（作为主要作者和高级作者）和校外研究支持（6 R01，1 R03、2个研究培训补助金，2个中心赠款部分，一个主要中心的科学共同指导和6个基金会赠款奖）证明了这一点。但是，候选人K02的到期导致他必须承担与这项研究无关的主要临床和行政责任。这发生在关键时刻，因为这个新领域（遗传学）需要高度专业化的培训，并增加对学员对这一专业知识的依赖。因此，K24奖对于维持候选人以患者为导向的研究和与研究相关的指导激活至关重要。此外，该奖项将使候选人能够沉浸在快速变化的领域，从而促进他掌握物质依赖遗传学新独立研究技能的掌握。该奖项的理由是由一项全面的5年职业发展计划提供的，1）候选人可以提高复杂特征的遗传学 /药物遗传学技能，以及2）使候选人能够继续他对临床研究的初学研究人员的指导。强化培训是由校园内课程，壁外教学，个性化录取，互动研讨会和与研究相关的组织会议的综合课程提供的。详细介绍了两项代表性研究 - 包括1）对多巴胺β-羟化酶（DBH）中可卡因，二硫酸酯和遗传变异（C-1021T）的药物遗传学研究的药物依赖性研究。