Treatment of Opioid Dependence and Chronic Pain

阿片类药物依赖和慢性疼痛的治疗

• 批准号: 8239594
• 负责人: Jennifer Sharpe Potter
• 金额: $ 17.27万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8239594
• 关键词: Address; Alcohol or Other Drugs use; Attitude; Behavior Therapy; Behavioral; Characteristics; Client satisfaction; Clinical; Clinical Trials; Cognitive; Cognitive Therapy; Dependence; Development Plans; Doctor of Medicine; Doctor of Philosophy; Emotional; Emotions; Ethical Issues; Evidence based treatment; Health; Individual; Intervention; Knowledge; Literature; Longitudinal Studies; Manuals; Mentored Patient-Oriented Research Career Development Award; Opiate Addiction; Opioid; Opioid Analgesics; Outcome; Pain; Participant; Patients; Pilot Projects; Population; Population Study; Psychologist; Research; Role; Series; Staging; Symptoms; Testing; Training; Training Activity; avoidance behavior; base; career; career development; chronic pain; cognitive enhancement; cohort; design; experience; psychosocial; response; responsible research conduct; skills training; social; social cognitive theory; therapy development; treatment as usual; treatment strategy

DESCRIPTION (provided by applicant): Project Summary: This is a resubmission of an application reviewed initially in July 2006. This K23 Mentored Patient-Oriented Research Career Development Award will permit, Dr. Jennifer Potter, a clinical psychologist, to obtain advanced training in the treatment of chronic pain and opioid dependence in order to conduct treatment-related research on co-occurring chronic pain and opioid dependence. The specific aims of this career development plan are to: 1) obtain advanced training in chronic pain treatment and assessment; 2) develop a greater understanding of the design and statistical analysis of longitudinal studies and clinical trials; 3) acquire further knowledge of opioid dependence treatment; 4) explore integrated psychosocial treatment for co-occurring opioid dependence and chronic pain; and 5) obtain advanced training in responsible conduct of research including ethical issues related to chronic pain. Dr. Potter will be guided by her sponsor, Roger Weiss, M.D., and three co-sponsors, David Borsook, M.D., Robert Jamison, Ph.D., and Garrett Fitzmaurice, Sc.D. The primary objective of the proposed research is to develop an integrated psychosocial treatment for co-occurring opioid dependence and chronic pain based on formative research. Specific Aim 1 will test the hypothesis that individuals with co-occurring chronic pain and opioid dependence have specific physical, emotional, and situational antecedents for their substance misuse distinct from individuals without chronic pain. Specific Aim 2 will test the hypothesis that chronic pain-related factors predict illicit opioid use following treatment for opioid dependence. Specific Aim 3 is to develop and test the feasibility and acceptability of a cognitive-behavioral manualized treatment for co-occurring opioid dependence and chronic pain. To accomplish these aims, I propose a series of three studies sequenced to coincide with training activities. Specific Aims 1 and 2, addressed in the initial two studies, will inform Specific Aim 3 examined in the study. Findings from the first two studies will guide selection of evidence-based treatment strategies and development of original treatment strategies as necessary. PUBLIC HEALTH RELEVANCE: Existing literature suggests that co-occurring opioid dependence and chronic pain are common. Specific treatment needs of individuals with both conditions are not well characterized. This proposal examines treatment needs within this population and develops a psychosocial intervention to address them.

DESCRIPTION (provided by applicant): Project Summary: This is a resubmission of an application reviewed initially in July 2006. This K23 Mentored Patient-Oriented Research Career Development Award will permit, Dr. Jennifer Potter, a clinical psychologist, to obtain advanced training in the treatment of chronic pain and opioid dependence in order to conduct treatment-related research on co-occurring chronic pain and opioid dependence.该职业发展计划的具体目的是：1）获得慢性疼痛治疗和评估方面的高级培训； 2）对纵向研究和临床试验的设计和统计分析有更深入的了解； 3）获得有关阿片类药物依赖治疗的进一步知识； 4）探索综合的心理社会治疗，以进行同时发生的阿片类药物依赖性和慢性疼痛； 5）获得负责任进行研究的高级培训，包括与慢性疼痛有关的道德问题。 Potter博士将由她的赞助商Roger Weiss，医学博士和三位共同发起人，David Borsook，M.D。，Robert Jamison，Ph.D。和SC.D. Garrett Fitzmaurice。拟议的研究的主要目的是开发一种基于形成性研究的综合心理社会治疗，以用于同时发生的阿片类药物依赖和慢性疼痛。具体目标1将检验以下假设：慢性疼痛和阿片类药物依赖性的个人具有特定的身体，情感和情境先例，因为其物质滥用与没有慢性疼痛的个体不同。具体目标2将检验以下假设：慢性疼痛相关因素可以预测阿片类药物依赖性治疗后的非法阿片类药物使用。具体目的3是开发和测试认知行为手动治疗的可行性和可接受性，用于同时发生的阿片类药物依赖性和慢性疼痛。为了实现这些目标，我提出了一系列与培训活动一致的三项研究。在最初的两项研究中解决的具体目的1和2将在研究中检查特定目标3。前两项研究的发现将指导基于证据的治疗策略和必要的原始治疗策略的制定。 公共卫生相关性：现有的文献表明，阿片类药物依赖和慢性疼痛很常见。两种情况下的个体的特定治疗需求没有很好地表征。该提案检查了该人群中的治疗需求，并开发了一种社会心理干预来解决这些干预。

项目成果

Neurophysiological mechanisms in acceptance and commitment therapy in opioid-addicted patients with chronic pain.

• DOI: 10.1016/j.pscychresns.2016.03.001
• 发表时间: 2016-04-30
• 期刊: Psychiatry research. Neuroimaging
• 作者: Smallwood RF;Potter JS;Robin DA
• 通讯作者: Robin DA

Pain, psychological flexibility, and continued substance use in a predominantly hispanic adult sample receiving methadone treatment for opioid use disorder.

接受美沙酮治疗阿片类药物使用障碍的主要西班牙裔成人样本的疼痛、心理灵活性和持续物质使用。

• DOI: 10.1016/j.drugalcdep.2019.107681
• 发表时间: 2020
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Rosen,KristenD;Curtis,MeganE;Potter,JenniferS
• 通讯作者: Potter,JenniferS