Neuroimaging Youth with Callous-Unemotional CD & Comorbid Substance Abuse

冷酷无情 CD 的神经影像青少年

• 批准号: 8307462
• 负责人: GINA M VINCENT
• 金额: $ 18.12万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307462
• 关键词: Adolescence; Adolescent; Adult; Affect; Affective; Age; Age of Onset; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Amphetamines; Amygdaloid structure; Anterior; Attention; Behavior; Bilateral; Brain; Childhood; Chronic; Cognition; Community Networks; Comorbidity; Conduct Disorder; Cost Savings; Crime; Cues; Dependence; Development; Development Plans; Diagnosis; Disease; Drug Addiction; Drug abuse; Drug usage; Early identification; Emotional; Empathy; Esthesia; Etiology; Functional Magnetic Resonance Imaging; Functional disorder; Hares; Human; Image; Imaging technology; Imprisonment; Impulsivity; Individual; Intervention; Justice; Knowledge; Laboratories; Lead; Long-Term Effects; Longitudinal Studies; Magnetic Resonance Imaging; Male Adolescents; Massachusetts; Measures; Mental Health; Mental disorders; Mentors; Methodology; Methods; Monitor; Neurobiology; Neurocognitive; Neurons; Neurosciences; New Mexico; Pattern; Personality; Personality Assessment; Personality Disorders; Pharmaceutical Preparations; Pilot Projects; Population; Prevention strategy; Process; Psychopath; Psychosocial Factor; Public Health; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Retrospective Studies; Rewards; Sampling; Severities; Substance Use Disorder; Substance abuse problem; Superior temporal gyrus; System; Taxes; Time; Training; Translational Research; Universities; Violence; Youth; addiction; aged; anti social; blood oxygen level dependent; callous unemotional trait; career; career development; cingulate gyrus; craving; drug abuser; drug craving; drug of abuse; early onset drug use; effective intervention; experience; frontal lobe; hemodynamics; imaging modality; interest; juvenile delinquent; male; medical schools; neuroimaging; neuropsychological; offender; prevent; prospective; psychopathic personality; public health relevance; response; stimulant abuse; substance abuse treatment; substance abuser; trait; treatment strategy; young adult

DESCRIPTION (provided by applicant): Understanding the neurobiological and psychosocial factors that are associated with early drug abuse requires better knowledge of specific subtypes of adolescent drug abusers, including those who have underlying callous-unemotional traits and serious conduct disorder (CU-CD). Youth with CU-CD are on a trajectory toward psychopathic personality in adulthood and drug addiction, crime, and violent behavior. They have more severe drug use and an earlier onset than other adolescent drug abusers, and therefore may have a neurobiology and reward system that is non-selectively activated to any drugs of abuse. There may be a need for treatment and prevention strategies tailored for CU-CD youth. The Candidate proposes a five-year K01 career development plan to launch an independent research career that focuses on the CU-CD population and blending neuropsychological and personality assessments with neuroimaging to better understand the early trajectory towards drug addiction to inform treatment for this population. The training plan includes mentored experience and coursework to increase knowledge in research on drug abuse and treatment, drug craving methodology, the neurobiology of development, and functional magnetic resonance imaging (fMRI) methods. The research projects (conducted in two settings) will examine the presence of neurocognitive and affective processing abnormalities in CU-CD youth with co-morbid stimulant abuse/dependence, relative to non-CU-CD youth with stimulant abuse/dep and controls, in response to craving tasks. This application integrates the candidate's background in assessment of CU-CD in adolescents and longitudinal studies of their chronic antisociality with a mentor team experienced in neuroimaging: Drs. Jean King and Jean Frazier at the University of Massachusetts Medical School (UMMS), and Dr. Kent Kiehl at the University of New Mexico and the Mental Illness and Neuroscience Discovery (MIND) Research Network. UMMS and the MIND have unique resources; including, a 3T magnet for human fMRI research, a craving laboratory, a large adolescent addiction treatment population and community network, and a mobile 1.5T fMRI system with access to a serious young offender population in a correctional facility. PUBLIC HEALTH RELEVANCE: The relevance to public health will be to better understand this problem and how to adapt treatments for CU-CD youth, including ways to increase translational research through new studies. Better understanding the neurobiological and psychosocial factors affecting CU-CD youth should help the addiction, mental health, and justice system to have both an immediate and long term effect on reducing drug addiction.

描述（由申请人提供）：了解与早期药物滥用相关的神经生物学和社会心理因素需要更好地了解青少年药物滥用者的特定亚型，包括那些具有基本冷酷无情的特征和严重行为障碍（CU-CD）的人。 Cu-CD的青年在成年和吸毒，犯罪和暴力行为方面处于精神病性格的轨迹。与其他青少年滥用药物相比，它们具有更严重的药物使用和更早的发作，因此可能具有神经生物学和奖励系统，该系统非选择性地激活任何滥用药物。可能需要针对CU-CD青年量身定制的治疗和预防策略。候选人提出了一项为期五年的K01职业发展计划，旨在启动独立的研究职业，重点是CU-CD人群，并将神经心理学和个性评估与神经影像融为一体，以更好地了解早期的吸毒成瘾轨迹，以告知该人群的治疗。培训计划包括指导的经验和课程，以增加有关药物滥用和治疗的研究知识，渴望方法论，开发神经生物学以及功能磁共振成像（fMRI）方法。研究项目（在两种环境中进行）将研究与非CU-CD青少年的兴奋性滥用/DEP和控制的Cu-CD青年中神经认知和情感处理异常的存在。该应用程序将候选人在青少年评估CU-CD的背景以及对其长期反社会性的纵向研究中与神经影像学方面的导师团队相结合：DRS。马萨诸塞大学医学院（UMMS）的让·金（Jean King）和让·弗雷泽（Jean Frazier），以及新墨西哥大学的肯特·基尔（Kent Kiehl）博士以及精神疾病和神经科学发现（MIND）研究网络。 Umms和思想有独特的资源；包括3T磁铁用于人类功能磁共振成像研究，渴望实验室，大量的青少年成瘾治疗人群和社区网络以及一个可移动的1.5T fMRI系统，该系统可以在惩教设施中访问认真的年轻罪犯。 公共卫生相关性：与公共卫生的相关性将是更好地了解该问题以及如何适应Cu-CD青年的治疗方法，包括通过新研究增加转化研究的方法。更好地了解影响CU-CD青年的神经生物学和社会心理因素应有助于成瘾，心理健康和司法系统对减少药物成瘾产生直接和长期影响。