SUPPRESSION OF BREAKTHROUGH BLEEDING IN USERS OF PROGESTIN CONTRACEPTIVES

抑制孕激素避孕药使用者的突破性出血

• 批准号: 7958423
• 负责人: OV D SLAYDEN
• 金额: $ 8.03万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-04 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958423
• 关键词: Animal Model; Breakthrough Bleeding; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Agents; Contraceptive methods; Endometrium; Funding; Goals; Grant; Hemorrhage; Implant; Institution; Intrauterine Devices; Levonorgestrel; Macaca mulatta; Methods; Mirena; Norplant; Primates; Progesterone; Progestins; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; Uterine hemorrhage; Woman; experience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levonorgestrel (LNG)-releasing implants (e.g. Norplant) and LNG-releasing intrauterine devices (LNG-IUS; e.g. Mirena IUS) are effective methods of contraception for women. However, women using these methods frequently experience breakthrough uterine bleeding (BTB) that often leads them to discontinue this form of contraception. Rhesus macaques also display BTB when treated with LNG-IUS, and can provide an animal model for assessing therapies to control the bleeding. Our goal in this research is to utilize rhesus macaques to characterize the effects of LNG-IUS on the endometrium and to test intermittent progesterone antagonist (PA) therapy as a treatment for BTB triggered by LNG-IUS use.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 释放左炔诺孕酮 (LNG) 的埋植剂（例如 Norplant）和释放 LNG 的宫内节育器（LNG-IUS；例如 Mirena IUS）是女性有效的避孕方法。 然而，使用这些方法的女性经常会出现突破性子宫出血 (BTB)，这往往导致她们停止这种避孕方式。 恒河猴在接受 LNG-IUS 治疗时也会表现出 BTB，并且可以提供用于评估控制出血疗法的动物模型。 我们这项研究的目标是利用恒河猴来表征 LNG-IUS 对子宫内膜的影响，并测试间歇性黄体酮拮抗剂 (PA) 疗法作为 LNG-IUS 使用引发的 BTB 的治疗方法。