Neuroadaptions in Drug Self-Administration and Relapse

药物自我给药和复发的神经适应

• 批准号: 7513609
• 负责人: David W Self
• 金额: $ 22.34万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513609
• 关键词: Abstinence; Animals; Arts; Behavior; Behavioral; Behavioral Model; Brain-Derived Neurotrophic Factor; Chronic; Cocaine; Condition; Cyclic AMP-Responsive DNA-Binding Protein; Cyclin-Dependent Kinase 5; Dominant-Negative Mutation; Dopamine D2 Receptor; Dopamine Receptor; Exposure to; Extinction (Psychology); Gene Targeting; Gene Transfer; Genes; Goals; Incentives; Individual Differences; Intake; Knock-out; Learning; Locomotion; Maintenance; Mediating; Modeling; Mus; Nucleus Accumbens; Pharmaceutical Preparations; Phenotype; Procedures; Protein Overexpression; Proteins; Rattus; Receptor Signaling; Regulation; Reinforcement Schedule; Relapse; Research Design; Rewards; Role; Self Administration; Self Stimulation; Self-Administered; Sprague-Dawley Rats; System; Technology; Testing; Time; Transcriptional Activation; Transgenic Mice; Transgenic Organisms; Up-Regulation; Viral; Week; Withdrawal; Work; addiction; cell type; day; drug of abuse; human RGS2 protein; neuroadaptation; preference; protein function; putamen; research study