ANIMAL CORE

动物核心

基本信息

批准号：
7389838
负责人：
HUDA AKIL
金额：
$ 18.01万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-25 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7389838
关键词：
Addictive Behavior Address Affect Animal Husbandry Animal Model Animal Testing Animals Applications Grants Behavior Behavioral Birth Breeding Caring Characteristics Cocaine Condition Conflict (Psychology)Development Dimensions Disease Drug abuse Environment Exhibits Exploratory Behavior Food Gene Expression Generations Genotype Glucocorticoid Receptor Home environment Human Impulsivity Individual Laboratories Life Literature Measures Modeling Molecular Motor Activity Mus Normal Statistical Distribution Novelty-Seeking Behaviors Numbers Operant Conditioning Partner in relationship Pharmaceutical Preparations Phase Phenotype Population Program Research Project Grants Prosencephalon Protein Overexpression Psychotropic Drugs Purpose Rattus Research Personnel Resources Rewards Risk-Taking Rodent Self Administration Self-Administered Social Impacts Stimulus Stress Substance abuse problem Sucrose System Testing Tetanus Helper Peptide Time Tissues Transgenes Transgenic Animals Transgenic Mice Transgenic Model Wild Animals base brain morphology drug of abuse drug seeking behavior indexing mouse model novel programs psychostimulant relating to nervous system response social success trait

项目摘要

Animal Core will serve all of the proposed projects in this application. It will provide continued selective breeding and behavioral characterization of two lines of rats that have been bred for 8 generations on the basis of differences in novelty-seeking. This trait is related to differential responsiveness to drug abuse and to differences in other behavioral and neural characteristics. The Core will conduct the animal husbandry, the testing needed for continued breeding of the colony, the initial behavioral characterization (e.g. locomotor tests) of the animals prior to transferring them to the individual investigators for specific studies. Moreover, the Animal Core will maintain the two mouse lines necessary for Project 4, with either constitutive or inducible GR over-expression. It will conduct the genotyping necessary for identifying the transgenic animals and wild type littermates prior to their use for the proposed specific studies.

Animal Core 将服务于本申请中的所有拟议项目。它将提供持续的选择性已繁殖8代的两个品系大鼠的繁殖和行为特征追求新奇差异的基础。这一特征与对药物滥用的不同反应有关其他行为和神经特征的差异。核心将开展畜牧业、继续繁殖群体所需的测试、初始行为特征（例如运动在将动物转移给个别研究人员进行特定研究之前，对动物进行测试）。此外，动物核心将维持项目 4 所需的两个小鼠品系，其中任一组成型或诱导性 GR 过度表达。它将进行鉴定转基因所需的基因分型动物和野生型同窝动物在用于拟议的具体研究之前。