Research Education in Statistical Genetics of Substance Abuse

药物滥用统计遗传学研究教育

• 批准号: 8305142
• 负责人: MICHAEL CHURTON NEALE
• 金额: $ 37.99万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305142
• 关键词: Addictive Behavior; Address; Adolescent; Alcohol or Other Drugs use; Alcohols; Animal Model; Area; Behavioral; Behavioral Genetics; Biometry; Clinical; Commit; Communities; Comorbidity; Computer Simulation; Computer software; DNA; Data; Data Analyses; Data Set; Databases; Dependence; Development; Doctor of Philosophy; Education; Education Projects; Educational Curriculum; Educational process of instructing; Educational workshop; Environment; Epidemiologist; Exposure to; Faculty; Fostering; Foundations; Funding; Future; Genes; Genetic; Genetic Polymorphism; Genetic Programming; Genetic Research; Genetics and Medicine; Genome Scan; Genotype; Goals; Grant; Health; Human; Human Genetics; Individual; Institutes; Institution; Interdisciplinary Study; Internet; Knowledge; Libraries; Machine Learning; Mathematics; Measurable; Mentors; Methodology; Methods; Mission; Modeling; Molecular; Molecular Biology; Molecular Genetics; Monitor; Mus; National Institute of Drug Abuse; O-(glucuronic acid 2-sulfate)-(1--4)-O-(2,5)-anhydromannitol 6-sulfate; Participant; Pattern; Pharmaceutical Preparations; Pharmacology; Pharmacology and Toxicology; Phenotype; Positioning Attribute; Postdoctoral Fellow; Predisposing Factor; Prevention; Psychiatry; Psychology; Psychometrics; Publishing; Queensland; Recruitment Activity; Relative (related person); Research; Research Personnel; Research Project Grants; Research Training; Resources; Sampling; Scientist; Series; Statistical Methods; Statistical Models; Structure; Students; Substance abuse problem; Time; Training; Training Programs; Twin Multiple Birth; Universities; Virginia; Work; Writing; addiction; base; career; career development; cohort; computer science; design; experience; field study; flexibility; genetic epidemiology; genome wide association study; human subject; medical specialties; meetings; model development; multidisciplinary; novel; population based; post-doctoral training; pre-doctoral; professor; programs; psychogenetics; software development; statistics; tool; web site

This application seeks support from the National Institute on Drug Abuse R25 mechanism for pre-doctoral and postdoctoral research positions at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). The overall goal of this research education program is to provide an environment that encourages the development and application of statistical genetics at the highest levels. To accomplish this goal, a research education program in statistical genetics will been developed to foster interdisciplinary research, a key tenet of the NIDA mission, and which we believe is essential to conducting research in this field. Two areas of research focus are identified: Advanced Genetic Epidemiology and Statistical Molecular Genetics. These areas are synergistic and address a diverse variety of statistical methods, both those in current use and those under development. The research education program consists of pre-doctoral and postdoctoral components. Pre-doctoral participants will pursue degrees in either Human and Molecular Genetics or Biostatistics. This component is designed to recruit, at the earliest time in their careers, potential future investigators to research in statistical genetics focused on substance use, abuse and dependence (SUAD). The aim is to create a cohort of PhD graduates who are have been extensively exposed to, and begun to publish research in, this area at the outset of their research training. The postdoctoral component recognizes that many promising young researchers have training in areas relevant to, but not focused on, the statistical genetics of substance use and abuse. This flexible 2-3 year postdoctoral training component will help guide young investigators to this field of study and will provide them with integrated and focused training that will enable them to pursue careers in statistical genetics of SUAD. Research education is intended for individuals with training in mathematics, statistics, biostatistics, genetics, psychology or pharmacology and to those who have completed their clinical requirements for the MD degree. The goal of the postdoctoral component is to educate independent investigators who will contribute to the efforts to identify and characterize the genetic and environmental determinants of SUAD; they are expected to do so at VCU and at other institutions nationwide. To accomplish the overall program goal we will: i) Offer and carefully monitor a multidisciplinary integrated research training program with a range of research opportunities; ii) Meet the needs for training in emerging research areas in SUAD; iii) Provide training to researchers from diverse academic and ethnic backgrounds and intensive mentoring; iv) Provide a specialized curriculum that will merge strengths in SUAD research at our institution; and v) Disseminate course materials, developed software, user guides and example scripts to the wider community by teaching workshops and establishing a website with web casts, pod casts and script libraries.

该申请寻求美国国家药物滥用研究所R25机制的支持，以在弗吉尼亚联邦大学（VCU）的弗吉尼亚精神病学和行为遗传学研究所（VIPBG）的博士前和博士后研究职位。该研究教育计划的总体目标是提供一个鼓励最高统计遗传学发展和应用的环境。为了实现这一目标，将制定一项研究统计遗传学的研究教育计划，以促进跨学科研究，这是NIDA任务的主要宗旨，我们认为这对于在该领域进行研究至关重要。确定了研究重点的两个领域：晚期遗传流行病学和统计分子遗传学。这些领域具有协同作用，并涉及各种统计方法，无论是当前使用和正在开发的方法。研究教育计划包括博士前和博士后组成部分。博士前的参与者将攻读人和分子遗传学或生物统计学的学位。该组成部分旨在在其职业生涯中最早招募潜在的未来研究人员，以研究统计遗传学的研究，重点是使用物质使用，滥用和依赖性（SUAD）。目的是创建一系列博士学位毕业生，这些毕业生在研究培训的一开始就广泛接触并开始在该领域发表研究。博士后部分认识到，许多有前途的年轻研究人员在与药物使用和滥用的统计遗传学有关的领域进行了培训。这个灵活的2 - 3年的博士后培训组成部分将有助于指导年轻的研究人员进入这一研究领域，并将为他们提供综合而专注的培训，使他们能够从事SUAD统计遗传学的职业。研究教育适用于接受数学，统计学，生物统计学，遗传学，心理学或药理学培训的人，以及完成了MD学位临床要求的人。博士后部分的目的是教育独立研究人员，他们将为识别和表征SUAD的遗传和环境决定因素做出贡献；预计他们将在VCU和全国其他机构这样做。为了实现总体计划目标：i）提供并仔细监视具有一系列研究机会的多学科综合研究培训计划； ii）满足SUAD新兴研究领域培训的需求； iii）为来自不同学术和种族背景和密集指导的研究人员提供培训； iv）提供专门的课程，该课程将在我们机构的SUAD研究中合并；和v）通过教授讲习班并建立一个网站，将课程材料，开发的软件，用户指南和示例脚本传播给更广泛的社区，并建立一个网站，其中包括网络演员，吊舱演员和脚本库。