Fetal Programming and Environmental Exposures: Implications for Prenatal Care and

胎儿编程和环境暴露：对产前护理和治疗的影响

• 批准号: 8319101
• 负责人: Sudhansu K Dey
• 金额: $ 1.4万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-07 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319101
• 关键词: Academia; Academy; Address; Adult; Adverse effects; Advocate; Affect; Award; Basic Science; Behavior; Blindness; Cardiovascular Diseases; Cerebrum; Child; Childhood; Chronic; Clinical; Collaborations; Communities; Complex; Congresses; Decidual Cell Reactions; Development; Diabetes Mellitus; Discipline; Disease; Embryo; Endocrine Disruptors; Endocrinologist; Environment; Environmental Exposure; Epidemiologist; Epigenetic Process; Event; Faculty; Family; Fees; Fellowship; Fostering; Future; General Population; Genes; Genetic; Goals; Government; Guidelines; Health; Hormones; Human; Hypertension; Individual; Industry; Infant; International; Intervention; Kidney; Knowledge; Lead; Learning; Learning Disabilities; Link; Lung; Marketing; Medical; Medical center; Minority; Mission; Multimedia; National Institute of Environmental Health Sciences; Neonatal; New York; New York City; Nurses; Online Systems; Oral; Organogenesis; Outcome; Patients; Pediatric Hospitals; Pharmacologic Substance; Physicians; Placentation; Play; Policies; Postdoctoral Fellow; Predisposing Factor; Premature Birth; Prenatal care; Prevention; Prevention strategy; Preventive; Price; Public Health; Publications; Qualifying; Reporting; Reproductive Biology; Reproductive Medicine; Research; Research Personnel; Resolution; Risk; Role; Safety; Science; Scientific Advances and Accomplishments; Scientist; Societies; Solutions; Specialist; Term Birth; Therapeutic; Training; Translational Research; Travel; Woman; Work; abstracting; base; combat; design; disability; discount; economic cost; environmental chemical; environmental toxicology; evidence base; fetal; fetal programming; gene environment interaction; graduate student; hearing impairment; human disease; implantation; improved; in utero; lectures; literacy; member; multidisciplinary; pediatrician; posters; pregnancy disorder; preimplantation; premature; prenatal; prenatal influence; prevent; programs; psychologic; repository; symposium

DESCRIPTION (provided by applic) Over the past two decades, it has been increasingly recognized that the risk of adult health disorders can be markedly influenced by prenatal and infant environmental and pharmaceutical exposures. The New York Academy of Sciences (NYAS) and Cincinnati Children's Hospital Medical Center are jointly presenting a 1.5- day scientific symposium to explore recent discoveries, challenges, and future research directions that further our understanding of the complex environmental and genetic factors, and gene-gene and gene- environment interactions responsible for fetal programming in utero and pre-term birth. Organized by Drs. Sudhansu K. Dey, Jeffrey A. Whitsett, and Susan J. Fisher (investigators), this event will take place at the New York Academy of Sciences conference center in New York City on June 7-8, 2012. The goals of the symposium are to: (i) discuss genetic and epigenetic factors, in addition to environmental exposures in the intrauterine environment that have a profound effect on the trajectory of prenatal development and pre-term birth, including the effects on: implantation; placentation; organogenesis; and neonatal health, and how to combat these effects; (ii) foster and highlight the research contributions of young and minority investigators working in this field; and (iii) develop high-quality, open-access, web-based enduring materials, to disseminate the latest scientific findings from this fast-moving field to the global community. The conference agenda features a Keynote Address, plenary lectures with audience questions and discussion, breakout roundtable discussions, a panel discussion, and networking activities. We anticipate wide participation (200 attendees) by toxicologists, obstetricians, neonatologists, pediatricians, nurse specialists, endocrinologists, epidemiologists, public health and regulatory experts from basic research to clinical settings, including experts in embryonic, fetal, and childhood development, reproductive medicine and biology, and environmental toxicology. The incorporation of poster and short oral presentations by junior investigators selected from submitted abstracts, and the availability of discounted registration prices and travel fellowships will encourage participation of qualified junior investigators, fellos, physicians-in- training, graduate students, and post-docs to attend the conference. We will use targeted marketing to encourage women and minority scientists to apply for these fellowships and to participate in the conference. The discussions originating from this forum and their dissemination will foster cross-disciplinary dialogue and collaborations among complementary research and clinical groups and lead to enhanced translation of research discoveries into: (i) improved understanding of the factors involved in fetal programming in utero and pre-term birth; (ii) the identification of ways in which to predict, assess, and lower the risk of and/or prevent environmental and genetic factors that predispose to adverse fetal outcomes and pre-term birth; and (iii) related, new health and safety guidelines, and public health programs for families and children. 1 PUBLIC HEALTH RELEVANCE: Prenatal and infant environmental and pharmaceutical exposures can adversely influence fetal programming, which plays a role in pre-term birth and lasting adverse effects on pulmonary, renal, and cerebral function, behavior and learning disabilities, and vision and hearing loss and is linked to chronic adult conditions such as diabetes, high blood pressure, and cardiovascular disease. The 1.5-day scientific symposium presented by the New York Academy of Sciences and Cincinnati Children's Hospital Medical Center will provide a neutral forum for toxicologists, obstetricians, neonatologists, pediatricians nurse specialists, endocrinologists, epidemiologists, and public health and regulatory experts from basic research to clinical settings to explore recent discoveries regarding the complex array of environmental (chemical, pharmaceutical or environmental) and genetic factors responsible for fetal programming in utero and pre-term birth. This forum will generate enduring, open-access, online publications to highlight the effects of environmental exposures on embryonic, fetal, and childhood development and reproductive medicine and biology, and will be available to the global scientific community in perpetuity. Thus, this activity will foster cross-disciplinary dialogue and collaboration and promote the development of effective clinical interventions and guidelines, preventive strategies, and new policies to lower the risk of and/or prevent environmental and genetic interactions that predispose to adverse fetal outcomes and pre-term birth.

描述（由申请提供）在过去二十年中，人们越来越认识到，成人健康障碍的风险可能会受到产前和婴儿环境和药物暴露的显着影响。纽约科学院（NYAS）和辛辛那提儿童医院医疗中心（NYAS）和辛辛那提儿童医疗中心共同举办1.5天的科学研讨会，以探索最近的发现，挑战和未来的研究方向，以进一步了解我们对复杂的环境和遗传因素，以及基因 - 基因 - 基因和基因环境的相互作用，以及负责对Utero和Pre-Orter term-Omerm Birth和Pre-Omer-Omer-Omer-Orter-Omer-Omer-Omerm Birth和Pre-Omer-Omerm Birth and pre-Omerm Birth and pre-Omer-Omerm byter-Omer-ember byter-emern。由Drs组织。 Sudhansu K. Dey，Jeffrey A. Whitsett和Susan J. Fisher（调查人员）将于2012年6月7日至8日在纽约纽约市的纽约科学学院会议中心举行。研讨会的目标是：（i）遗传和表观遗传因素，除了在环境环境中的发展以及在临床环境中的发展，该遗传和表观性因素在临床环境中的发展效果和表观效果深刻效果，并且在临时环境中的发展效果是一项深刻的效果。出生，包括对：植入的影响；胎盘器官发生；和新生儿健康，以及如何对抗这些影响； （ii）培养和强调在该领域工作的年轻和少数民族研究人员的研究贡献； （iii）开发高质量的，开放式，基于网络的持久材料，以传播这个快速发展的领域的最新科学发现 到全球社区。会议议程设有主题演讲，全体会议讲座以及受众群体问题和讨论，突破性圆桌讨论，小组讨论和网络活动。我们预计毒理学家，妇产科医生，新生儿学家，儿科医生，护士专家，内分泌学家，流行病学家，毒理学家，新生儿学家，新生儿学家，新生儿学家，新生儿学家，年龄学家，200名参与者的参与（200名参与者） 公共卫生和监管专家从基础研究到临床环境，包括专家 胚胎，胎儿和儿童期发展，生殖医学和生物学以及环境毒理学。从提交的摘要中选出的初级调查人员的海报和简短的口头演讲以及折现注册价格和旅行奖学金的可用性将鼓励合格的初级调查人员，家伙，培训医师，研究生，研究生和课后参加会议的参与。我们将使用有针对性的营销来鼓励妇女和少数族裔科学家申请这些奖学金并参加会议。源自该论坛及其传播的讨论将促进跨学科的对话以及互补研究和临床小组之间的合作，并导致研究发现的翻译加剧：（i）对胎儿编程中涉及子宫内胎儿编程的因素的了解； （ii）鉴定预测，评估和降低和/或防止环境和遗传因素的风险和/或降低胎儿不利的胎儿结局和前分娩的风险的方法； （iii）有关家庭和儿童的新的健康与安全指南以及公共卫生计划。 1 公共卫生相关性：产前和婴儿的环境和药物暴露会对胎儿编程产生不利影响，这在肺部出生和对肺部，肾功能和脑功能，行为和学习障碍，视力和视力和障碍的持久不良影响中起作用，并与糖尿病等长期疾病（如高血压疾病）联系起来，并与慢性成人疾病联系起来。由纽约科学院和辛辛那提儿童医院医学中心举办的为期1.5天的科学研讨会将为毒理学家，产科医生，新生儿学家，新生儿学家，儿科专家，内分泌学家，内分泌学家，内分裂症学家，流行病学家以及临时性杂志的建筑群体提供一个中性的论坛药物或环境）以及负责子宫内胎儿编程的遗传因素。该论坛将产生持久的开放式在线出版物，以强调环境暴露对胚胎，胎儿和儿童期发展以及生殖医学和生物学的影响，并将永久地向全球科学界提供。因此，这项活动将促进跨学科的对话和协作，并促进有效的临床干预措施和指南，预防策略以及新政策的发展，以降低和/或防止环境和遗传相互作用的风险，这些风险易于不利的胎儿结果和前期出生。

项目成果

Fetal programming and environmental exposures: implications for prenatal care and preterm birth.

胎儿编程和环境暴露：对产前护理和早产的影响。

• DOI: 10.1111/nyas.12003
• 发表时间: 2012
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Schug,ThaddeusT;Erlebacher,Adrian;Leibowitz,Sarah;Ma,Liang;Muglia,LouisJ;Rando,OliverJ;Rogers,JohnM;Romero,Roberto;vomSaal,FrederickS;Wise,DavidL
• 通讯作者: Wise,DavidL