Structural and Biochemical Basis of the Vitamin K cycle

维生素 K 循环的结构和生化基础

• 批准号: 8166297
• 负责人: Weikai Li
• 金额: $ 24.9万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166297
• 关键词: Active Sites; Address; Amino Acids; Anticoagulants; Anticoagulation; Archaea; Bacteria; Binding; Biochemical; Biochemistry; Blood Coagulation Factor; Blood coagulation; Catalysis; Cells; Cellular biology; Complex; Coumarins; Coupled; Couples; Coupling; Crystallization; Cysteine; Deep Vein Thrombosis; Detergents; Disease; Disulfides; Drug Design; Electron Transport; Electrons; Environment; Enzymes; Glutamic Acid; Goals; Hemorrhage; Homologous Gene; Human; Hydroquinones; In Vitro; Injury; Instruction; Knowledge; Laboratories; Lead; Membrane; Mutation; Myocardial Infarction; Natural regeneration; Nature; Oral; Oxidation-Reduction; Pathway interactions; Pharmaceutical Preparations; Phase; Positioning Attribute; Post-Translational Protein Processing; Protein Biochemistry; Proteins; Pulmonary Embolism; Reaction; Research; Research Personnel; Schools; Site; Stroke; Structure; Testing; Therapeutic; Thioredoxin; Thrombosis; Time; Universities; Vitamin K; Warfarin; Washington; X-Ray Crystallography; alpha benzopyrone; base; carboxylation; cofactor; design; drug mechanism; gamma-glutamyl carboxylase; high risk; hydroquinone; improved; inhibitor/antagonist; luminal membrane; mutant; oxidation; prevent; professor; reconstitution; reduced vitamin K; research study; resistance mutation; vitamin K epoxide reductase; vitamin K1 oxide