Cancer gene discovery using Sleeping Beauty transposon-mediated mutagenesis

利用睡美人转座子介导的诱变发现癌症基因

• 批准号: 8281731
• 负责人: TIMOTHY Kaehler STARR
• 金额: $ 24.15万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8281731
• 关键词: AKAP13 gene; Address; Advisory Committees; Agar; Animal Model; Apoptosis; Area; Automobile Driving; Bioinformatics; Biological; Biometry; CUL3 gene; Cancer Center; Cancer Etiology; Cell Line; Colon Carcinoma; Colorectal Cancer; Comparative Pathology; Complementary DNA; Core Facility; Coupled; Cytogenetics; Data; Development; Diagnostic; Disease; Epigenetic Process; Epithelial Cells; Event; Fellowship; Flow Cytometry; Gene Mutation; Genes; Genetic; Genetic Screening; Genome; Goals; Growth; Heterogeneity; Histocompatibility Testing; Human; Human Cell Line; Image; Individual; Insertion Mutation; Intestines; Knock-in Mouse; Knock-out; Laboratories; Location; Lung; Lung Neoplasms; Malignant Neoplasms; Malignant neoplasm of lung; Maps; Measures; Mediating; Mentors; Messenger RNA; Methods; Minnesota; Modeling; Modification; Molecular Target; Mus; Mutagenesis; Mutate; Mutation; Normal tissue morphology; Oncogenes; Oncogenic; PTEN gene; Phase; Phenotype; Positioning Attribute; Postdoctoral Fellow; Primary carcinoma of the liver cells; Proteins; RNA Interference; Refractory; Regulation; Research; Research Personnel; Research Proposals; Resistance; Resource Sharing; Role; Secure; Signal Pathway; Signal Transduction; Sleeping Beauty; Somatic Mutation; System; Techniques; Technology; Testing; Tissue Procurements; Tissues; Transgenic Organisms; Transposase; Tumor Tissue; Universities; Work; abstracting; anticancer research; base; cancer therapy; career; career development; clinically relevant; colorectal cancer screening; gain of function mutation; gene discovery; gene function; improved; leukemia; lung cancer screening; mouse genome; mouse model; novel; overexpression; research and development; research study; sarcoma; success; therapeutic target; tumor; tumor growth; tumorigenesis