Functional Circuits as an Endophenotype for ADHD in Children

功能回路作为儿童多动症的内表型

基本信息

批准号：
8299841
负责人：
Damien A Fair
金额：
$ 24.9万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8299841
关键词：
Accounting Age Algorithms Architecture Attention Attention deficit hyperactivity disorder Award Behavior assessment Biological Assay Biological Markers Brain Cerebellum Characteristics Child Classification Clinical Clinical Research Clinical assessments Cognitive Communities Dementia Detection Development Dimensions Dorsal Emotional Environment Exhibits Family Functional Magnetic Resonance Imaging Funding Future Genetic Goals Graph Health Sciences Heterogeneity Hyperactive behavior Imaging Techniques Impulsivity Investigation Knowledge Laboratories Length Magnetic Resonance Imaging Maps Measures Mental disorders Mentors Metric Neuroanatomy Neurobiology Oregon Pathway interactions Patients Pattern Performance Phenotype Population Population Control Procedures Process Psychiatry Psychopathology Public Health Regulation Relative (related person)Research Research Personnel Rest Scientist Series Severities Short-Term Memory Siblings Subgroup Symptoms System Training Translating United States National Institutes of Health Universities Variant Washington Work Workplace Writing Youth base career career development endophenotype experience human subject improved inattention induced pluripotent stem cell insight medical schools meetings neural circuit neuropsychological novel patient population proband remediation theories trait trend

项目摘要

I am a 2nd year postdoctoral research scientist who arrived at OHSU after postgraduate training first at Yale University School of Medicine, and subsequently Washington University School of Medicine in St. Louis where I primarily focused on examining typical development of brain organization using fMRI and functional connectivity MRI. My goal is to establish my own independent laboratory in a University setting examining typical and atypical brain development in relation to mental disorders. In particular, I have well thought out ideas for a series of investigations regarding the potential for brain connectivity as a potential endophenotype in ADHD. To conduct such work, I need to gain expertise in issues related to research application of behavioral and clinical assessment, cognitive measures, neuropsychological measures, human subjects issues with clinical populations, and to gain expertise in writing and grantsmanship related to clinical problems. This agenda is the focus of my career development/training plan. The research environment provided by Oregon Health and Science University and the mentor of this award (Dr. Joel Nigg) is outstanding and a perfect fit for my career goals. Dr. Nigg, while not a neuroimager, is a well-known ADHD researcher with more than 10 years of continuous NIH R01 level funding. He has extensive mentoring experience and collaborates with other ADHD researchers around the world, providing ample opportunity for me to meet and interact with experts in many aspects of clinical research. The Pathway to Independence award, with its dual emphasis on training and independence, is an excellent fit for my future career goals.

我是一名二年级博士后研究科学家，在耶鲁大学完成研究生培训后来到 OHSU 大学医学院，随后是圣路易斯华盛顿大学医学院我主要专注于使用功能磁共振成像和功能性检查来检查大脑组织的典型发育。连接性 MRI。我的目标是在大学环境中建立自己的独立实验室与精神障碍相关的典型和非典型大脑发育。特别是我已经深思熟虑了关于大脑连接作为潜在内表型的潜力的一系列研究的想法多动症。为了进行此类工作，我需要获得与行为学研究应用相关的问题的专业知识和临床评估、认知测量、神经心理学测量、人类受试者问题临床人群，并获得与临床问题相关的写作和资助方面的专业知识。这议程是我职业发展/培训计划的重点。俄勒冈州提供的研究环境健康与科学大学和该奖项的导师（Joel Nigg 博士）非常出色，非常适合我的职业目标。 Nigg 博士虽然不是神经影像学家，但却是一位拥有 10 多年研究经验的著名 ADHD 研究人员持续的 NIH R01 级别资助。他拥有丰富的指导经验并与其他人合作世界各地的多动症研究人员为我提供了充足的机会与专家见面和互动临床研究的许多方面。独立之路奖双重强调培训和独立，非常适合我未来的职业目标。