CORE -- DIAGNOSIS AND SYMPTOM ASSESSMENT

核心——诊断和症状评估

• 批准号: 7557421
• 负责人: JOSEPH VENTURA
• 金额: $ 7.89万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-13 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7557421
• 关键词: Aftercare; Certification; Chronic Schizophrenia; Classification; Clinical; Consensus; DSM-IV; Device or Instrument Development; Diagnosis; Diagnostic; Emotions; Ensure; Evaluation; Goals; Gold; Interview; Interviewer; Libraries; Life; Measurement; Measures; Mental disorders; Methods; Mission; Neurocognition; Patients; Phase; Procedures; Psychiatric Diagnosis; Purpose; Rate; Research; Research Project Grants; SCAP2 gene; Sampling; Schizophrenia; Screening procedure; Standards of Weights and Measures; Structure; Symptoms; Time; Training; Training Programs; Update; Validity and Reliability; Videotape; base; deficit syndrome; improved; insight; instrument; method development; prevent; programs; quality assurance; remediation; skills; statistics

The primary goal of the Diagnosis and Symptom Assessment Core (DSAC) is to provide specialized diagnostic and psychiatric symptom assessment training and quality assurance procedures to projects and cores within the Translational Center for Neurocognition and Emotion in Schizophrenia. The DSAC will train interviewers who conduct screening and evaluation of patients across three phases of illness in the Prodromal Research Project, the Aftercare Research Program, and the Chronic Schizophrenia Recruitment and Assessment Core. The DSAC will be responsible for establishing and maintaining high levels of interrater reliability, preventing rater drift, and improving the reliability and validity of Center instruments. To accomplish these goals, the DSAC will: 1) maintain well standardized, comprehensive and reliable training and quality assurance methods for prodromal signs assessment, diagnosis of DSM-IV disorders, psychiatric symptom assessment, and measurement of insight, 2) maintain reliability standards and criteria for certification of diagnosticians, diagnostic interviewers, and symptom raters who use assessment instruments such as the SCID-I, SCID-II, SIPS, SOPS, BPRS, SANS, SAPS, and SUMD-R, 3) ensure high levels of interrater reliability for diagnosticians who will be conducting training and quality assurance procedures, and 4) expand the DSAC training videotape library to include updated structured interviews for generating diagnoses and symptom rating scales. Phase I of the training program requires that diagnostic interviewers and symptom assessors rate a minimum of six training videotapes and have interrater reliability calculated using the accompanying "Gold Standard" consensus diagnoses and ratings. For the SIPS, SOPS, BPRS, SANS, SAPS, and SUMD-R, we will require that the trainee obtain a minimum Intraclass Correlation Coefficient (ICC) of .80 across all items and all six training videotapes. These requirements must be met or the trainee will attend remediation sessions before "graduating" to Phase II of training, which requires conducting 4 "live" assessments for each measure. The DSAC will also formally evaluate interviewer style, e.g., ability to probe for symptoms. All interviewers will enter a quality assurance program aimed at preventing rater "drift." Each interviewer will be required to demonstrate, as evaluated with kappa and ICC statistics, high levels of interrater reliability by continuing to conduct "live" interviews and co-rating assessments conducted by a senior Center diagnostician. The DSAC will collaborate with other Cores for Clinical Samples and Center Projects around research questions such as instrument development, method development, and improving interrater reliability.

诊断和症状评估核心 (DSAC) 的主要目标是为精神分裂症神经认知和情感转化中心的项目和核心提供专门的诊断和精神症状评估培训和质量保证程序。 DSAC 将培训访谈员，在前驱研究项目、善后研究项目以及慢性精神分裂症招募和评估核心中对患者的三个疾病阶段进行筛查和评估。 DSAC 将负责建立和维持高水平的评估者间可靠性，防止评估者漂移，并提高中心仪器的可靠性和有效性。为了实现这些目标，DSAC 将：1) 维持良好标准化、全面且可靠的培训和质量保证方法，用于前驱体征评估、DSM-IV 疾病诊断、精神症状评估和洞察力测量，2) 维持可靠性标准和使用 SCID-I、SCID-II、SIPS、SOPS、BPRS、SANS、SAPS 和 SUMD-R 等评估工具的诊断医师、诊断访谈员和症状评估员的认证标准， 3) 确保将进行培训和质量保证程序的诊断人员具有高水平的参与者间可靠性，以及 4) 扩展 DSAC 培训录像带库，以包括用于生成诊断和结果的更新的结构化访谈 症状评定量表。培训计划的第一阶段要求诊断访谈员和症状评估员至少对六盘培训录像带进行评分，并使用随附的“黄金标准”共识诊断和评级计算参与者间的可靠性。对于 SIPS、SOPS、BPRS、SANS、SAPS 和 SUMD-R，我们将要求学员在所有项目和所有六个培训录像带中获得最低 0.80 的类内相关系数 (ICC)。必须满足这些要求，否则受训者将在“毕业”到第二阶段培训之前参加补救课程，第二阶段需要对每项措施进行 4 次“实时”评估。 DSAC 还将正式评估访调员的风格，例如探查症状的能力。所有面试官都将参加旨在防止评估者“漂移”的质量保证计划。每位面试官都需要根据 kappa 和 ICC 的评估进行证明 通过继续进行“实时”访谈以及由中心高级诊断师进行的共同评级评估，可以提高统计数据的可靠性。 DSAC 将与其他临床样本核心和中心项目围绕仪器开发、方法开发和提高仪器间可靠性等研究问题进行合作。