Immunobiology of Trauma

创伤免疫生物学

• 批准号: 8280447
• 负责人: Daniel G. Remick
• 金额: $ 23.89万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8280447
• 关键词: Immunobiology; Trauma

DESCRIPTION (provided by applicant): This T32 training grant proposal will provide post-doctoral training in the field of trauma and peri-operative injury. Traumatic injury is one of the major causes for the loss of life, loss of productivity and loss of years of life. Compared to other processes such as cancer or cardiovascular disease, trauma frequently occurs in a younger age group with corresponding increased years of life lost. Trauma also disproportionately affects underserved and minority populations making trauma a health disparities issue. Currently, traumatic injury represents an unmet medical need. Against this background we intend to train physicians and scientists in basic methods of research so that they may be applied to study of traumatic injury. We will request support for 3 fellows per year, and each fellow will spend 2 years working closely with a research mentor. It is useful to consider the grant in terms of 2 groups: One group consists of the training faculty who will provide the education and the second group is composed of the fellows who will be trained. We are fortunate to have a strong cadre of currently funded, active and senior mentors who will participate in this grant. There are a total of 18 investigators and labs that have collectively trained more than 200 fellows over the past 10 years. The strength of the faculty must be considered un-paralleled. The trainees will come from both the clinical programs and also the direct application to individual labs. An emphasis will be placed on recruiting physicians in the current residency programs since Boston University has a strong track record in recruiting a diverse group of physicians and placing our fellows in academic positions. Based on institutional information there are currently several physicians in training who wish to participate in basic science training. Boston University School of Medicine has a rich tradition of serving the underserved which attracts a significant number of minority physicians to our clinical training programs. They will be a significant source of potential trainees. The training program will recruit from several clinical departments above and beyond the Department of Surgery. The training program is specifically designed to minimize formal coursework and maximize the interactions with the mentors. Potential trainees will be exposed on a frequent basis during their clinical rotations to the training opportunities provided by this program. The concept is that bright young, energetic minds directly observing clinical problems will be stimulated to closely examine the mechanisms which directly cause morbidity and mortality in the trauma patients. Patients who have suffered a traumatic injury and survive the initial insult have increased loss of life over the next several years. Substantial morbidity occurs over the remainder of the patients' lives. The impact of the initial traumatic injury extends far beyond the first event. This grant will train physicians and scientists in the study of how traumatic injury causes this increase in loss of life and loss of function.

描述（由申请人提供）：该T32培训赠款建议将在创伤和围手术期伤害领域提供博士后培训。创伤性损伤是丧生，生产力丧失和生命年损失的主要原因之一。与其他过程（例如癌症或心血管疾病）相比，创伤经常发生在年龄段的人群中，相应地增加了生命年的增长。创伤也不成比例地影响服务不足和少数群体，这使创伤成为健康差异问题。目前，创伤性伤害代表了未满足的医疗需求。在这种背景下，我们打算培训医生和科学家的基本研究方法，以便将其应用于创伤性损伤的研究。我们将要求支持每年3名研究员的支持，每个研究员将与研究导师紧密合作2年。以两组的方式考虑赠款很有用：一个组由培训学院组成，他们将提供教育，第二组由将接受培训的研究员组成。我们很幸运能拥有一批目前有资助的，活跃和高级导师的干部，他们将参加这项赠款。在过去的10年中，共有18名调查人员和实验室对200多名研究员进行了培训。必须将教师的力量视为不相同。学员将来自两个临床计划，也将直接应用于单个实验室。自从波士顿大学在招募一群多样化的医生并将我们的研究员置于学术职位方面，将重点放在当前居住计划中的招聘医师。基于机构信息，目前有几位希望参加基础科学培训的医生。波士顿大学医学院拥有丰富的服务，可以为服务不足的服务提供服务，这吸引了大量少数族裔医生参加我们的临床培训计划。他们将是潜在学员的重要来源。该培训计划将从外科部以外的几个临床部门招募。该培训计划的专门设计旨在最大程度地减少正式课程并最大程度地提高与导师的互动。潜在的学员将在临床轮换期间频繁暴露与该计划提供的培训机会。这个概念是，将刺激直接观察临床问题的明亮，充满活力的头脑，以密切检查直接导致创伤患者发病率和死亡率的机制。在未来几年中，遭受创伤并生存的患者生命损失增加。在其余的患者生活中发生了大量发病率。最初的创伤损伤的影响远远超出了第一个事件。该赠款将培训医生和科学家，以研究创伤性损伤如何导致生命损失和功能丧失的增加。