ECC UNIT II

ECC 第二单元

• 批准号: 7508883
• 负责人: Avi Ma'ayan
• 金额: $ 16.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-18 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7508883
• 关键词: Back; Bioinformatics; Cluster Analysis; Code; Communities; Computer Simulation; Computer software; Copying Processes; Custom; Data; Data Set; Databases; Development; Documentation; Experimental Models; Extensible Markup Language; Facility Construction Funding Category; Gene Proteins; Genes; Image; Imagery; Information Management; Internet; Literature; Management Audit; Management Information Systems; Maps; Metadata; Microarray Analysis; Modeling; Names; Online Systems; Ontology; Output; Pharmaceutical Preparations; Proteins; PubMed; Publications; Purpose; Reporting; Research; Research Personnel; Research Project Grants; Retrieval; Security; Services; Source; Standardization; Standards of Weights and Measures; Study Section; SwissProt; System; data mining; data modeling; database design; human SLPI protein; image processing; member; programs; promoter; protein protein interaction; protocol development; repository; software development; tool; web based interface; wiki

ECC Unit 2. Information Management Unit (IMU) Investigator: Avi Ma'ayan Participating Investigators: Guillermo Cecchi and Gustavo Stolovitzky The Information Managements Unit (IMU) will centralize, federate, disseminate and manage all experimental data, models and computational results in a centralized coherent repository named Information Management System (IMS). The unit will also continue to expand current developments of data-mining by integrating and filtering qualitative and quantitative data from relevant external sources such as online databases and legacy experimental literature. The IMS repository will be continually populated with highcontent experimental data including imaging data from internal sources as described above, modeling results, models and software developed from internal sources, as well as data mined from external sources to enrich the content of the IMS repository. The IMU will maintain local copies of processed versions of publicly available external databases for genes, proteins, protein-protein interactions and drug-protein interactions (i.e. PubMed, EntrezGene (1), Swiss-Prot (2), and DrugBank(3)). The data produced by the internal experimental efforts and modeling efforts associated with the proposed projects will be annotated using metadata (data that describes the data). XML schemas(4), Object Oriented and Relational Database schemas (5) will be developed to organize all these data for the purpose of optimal search, visualization, web-access, download retrieval, statistical analysis and modeling, as well as for the purpose of configuration management, auditing, reporting, backup, and security. The computational modeling efforts and experimental efforts would both benefit from standardization of data exchange and storage schemas.

ECC 单元 2. 信息管理单元 (IMU) 调查员：阿维·马阿扬 参与调查员：Guillermo Cecchi 和 Gustavo Stolovitzky 信息管理单元（IMU）将集中、联合、传播和管理所有信息 实验数据、模型和计算结果存储在一个名为“信息”的集中式连贯存储库中 管理系统（IMS）。该部门还将继续扩大数据挖掘的当前发展 整合和过滤来自相关外部来源（例如在线）的定性和定量数据 数据库和遗留实验文献。 IMS 存储库将不断填充高内容 实验数据包括来自如上所述的内部来源的成像数据、建模结果、 从内部来源开发的模型和软件，以及从外部来源挖掘的数据以丰富 IMS 存储库的内容。 IMU 将维护公开的处理版本的本地副本 可用的基因、蛋白质、蛋白质-蛋白质相互作用和药物-蛋白质相互作用的外部数据库 （即 PubMed、EntrezGene (1)、Swiss-Prot (2) 和 DrugBank(3)）。内部产生的数据 与拟议项目相关的实验工作和建模工作将使用元数据进行注释 （描述数据的数据）。 XML 模式(4)、面向对象和关系数据库模式(5) 将被开发来组织所有这些数据，以实现最佳搜索、可视化、网络访问、 下载检索、统计分析和建模，以及用于配置管理的目的， 审计、报告、备份和安全。计算建模工作和实验工作将 两者都受益于数据交换和存储模式的标准化。