Exercise Treatment for Depressed Youth

抑郁青少年的运动治疗

基本信息

批准号：
7532396
负责人：
CARROLL W HUGHES
金额：
$ 22.49万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-17 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7532396
关键词：
Abbreviations Accounting Achievement Address Adherence Adolescence Adolescent Adult Adverse effects Advertisements Advocate Aerobic Aerobic Exercise Age Alcohols Ambulatory Care Facilities Antidepressive Agents Arts Attitude Behavior Body Image Cause of Death Child Childhood Clinical Cognitive Community Physician Condition Coronary Count Coupled DSM-IV Data Depressed mood Development Devices Diagnostic and Statistical Manual Disease Dose Drops Effectiveness of Interventions Energy Metabolism Exercise Exercise stress test Family Feasibility Studies Feedback Feeling Fluoxetine Future Gender Goals Heart Illicit Drugs Impairment Individual Institutes Internet Intervention Lead MCC protocol Major Depressive Disorder Manuals Measures Medical center Mental Depression Monitor Morbidity - disease rate NIH Program Announcements Nonparametric Statistics Numbers Online Systems Outcome Outcome Measure Outcome Study Outpatients Participant Patient Self-Report Patients Performance Pharmaceutical Preparations Physical activity Placebos Procedures Process Public Health Randomized Randomized Controlled Trials Rate Recovery Recruitment Activity Relative (related person)Research Project Grants Resistance Risk Role SAS Safety Schools Score Selective Serotonin Reuptake Inhibitor Services Severities Signal Transduction Social Adjustment Standards of Weights and Measures Statistical Models Stretching Suicide Techniques Testing Texas Time Training Week Wrist Writing Youth age group base career children&apos s depression rating scale compare effectiveness cost effective depressive symptoms design early onset functional outcomes impression improved mortality outcome forecast partial response preference prescription document prescription procedure psychosocial response size social therapy development tool treatment program unintended pregnancy

项目摘要

DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is common in adolescents and results in significant morbidity and mortality. Adolescent suicides are the third leading cause of death for this age group typically accounted for by depression. There is a high rate of only partial response to the most commonly used group of antidepressants (SSRIs) and increased controversy regarding their use for this age group. These findings coupled with recent decreased SSRI prescription rates with concomitant increases in suicide, constitutes an important public health problem. And for adolescents, there is a lack of available safe, effective, and easy to use nonmedication treatment alternatives with controlled data. Aerobic exercise can provide a safe, effective, minimal side effect treatment intervention that may be more acceptable to patients and potentially cost effective. This study proposes to 1) develop a depressed adolescent exercise treatment manual based on the recent successful UT Southwestern depressed adult exercise study, 2) evaluate the feasibility of using a standardized aerobic exercise regime to treat nonmedicated clinically depressed adolescents based on adherence and completion rates, 3) establish effect sizes for the primary outcome (the CDRS-R and Actical [energy expenditure data] as well as selected secondary outcomes; [e.g., QIDS-A17, attitudes], and 4) determine whether exercise versus stretching activity leads to clinically meaningful reduction in depressive symptoms and/ or improved psychosocial functioning. The proposed study will consist of providing AEROBIC EXERCISE or PLACEBO STRETCH to mild to moderately depressed nonmedicated adolescents recruited from community physicians, advertisements, and UT Southwestern outpatient clinics. Sixty clinically depressed adolescents of both genders between the ages of 12 -17 years who meet criteria for DSM-IV major depression (CDRS-R = 36 =70 and CDI-S = 4) will be randomized to an aerobic dose exercise or a placebo stretch condition for 12 weeks. Based on current recruitment, and rates achieved in the UT Southwestern adult depression exercise study at the Cooper Institute in Dallas, we anticipate at least 60 will be randomized to the 12 weeks exploratory feasibility trial in the allotted time. Comprehensive state of the art processes for monitoring adherence with web-based tools and Actical 24/7 monitoring are coupled with motivational techniques for depressed youth to assure a successful completion rate.

描述（由申请人提供）：重度抑郁症（MDD）在青少年中很常见，会导致显着的发病率和死亡率。青少年自杀是该年龄段的第三大死因，通常由抑郁症引起。最常用的抗抑郁药 (SSRIs) 仅有部分反应的比例很高，并且关于该年龄组使用这些药物的争议也越来越多。这些发现加上最近 SSRI 处方率的下降以及随之而来的自杀人数的增加，构成了一个重要的公共卫生问题。对于青少年来说，缺乏安全、有效、易于使用且数据受控的非药物治疗替代方案。有氧运动可以提供安全、有效、副作用最小的治疗干预措施，可能更容易被患者接受，并且可能具有成本效益。本研究建议 1) 根据最近成功的 UT 西南抑郁症成人运动研究制定抑郁症青少年运动治疗手册，2) 根据依从率和完成率评估使用标准化有氧运动方案治疗非药物临床抑郁症青少年的可行性， 3) 确定主要结果（CDRS-R 和实际[能量消耗数据]以及选定的次要结果；[例如 QIDS-A17、态度]）的效应大小，以及 4) 确定运动与伸展活动是否会导致临床上有意义的抑郁症状减轻和/或改善心理社会功能。拟议的研究将包括向从社区医生、广告和德州大学西南门诊诊所招募的轻度至中度抑郁的未接受药物治疗的青少年提供有氧运动或安慰剂拉伸。 60 名年龄在 12 -17 岁之间、符合 DSM-IV 重度抑郁症标准（CDRS-R = 36 = 70 和 CDI-S = 4）的临床抑郁青少年，将被随机分配到有氧运动或安慰剂组拉伸状态持续12周。根据目前的招募情况以及达拉斯库珀研究所 UT 西南成人抑郁症运动研究中所取得的比率，我们预计至少有 60 名患者将在规定的时间内被随机分配参加为期 12 周的探索性可行性试验。使用基于网络的工具和 Actical 24/7 监控来监控遵守情况的综合最先进流程与针对抑郁青少年的激励技术相结合，以确保成功完成率。