Mucosal Immunology Core

粘膜免疫学核心

基本信息

批准号：
7480739
负责人：
Peter A Anton
金额：
$ 6.05万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-15 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7480739
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Advertisements Applications Grants Area Awareness Biological Assay Biopsy Biostatistics Core Blood Blood Screening Blood specimen Books Cells Cervix Uteri Clinical Clinical Trials Colon, Rectum Communities Consent Forms Consult Consultations Core Facility Databases Development Epithelium Fostering Funding Gastroenterology Gastrointestinal tract structure Goals Grant HIV HIV Infections Human Immune response Immunologics Immunology Infection Institutes Knowledge Laboratories Link Lymphocyte Lymphoid Tissue Minority Mononuclear Mucous Membrane Operative Surgical Procedures Pathogenesis Patient Selection Patients Preparation Process Quality Control RNA Recruitment Activity Registries Research Research Design Research Ethics Committees Research Personnel Resources Sampling Seminal fluid Services Site Small Intestines Specimen Stomach Diseases Suspension substance Suspensions Techniques Technology Technology Transfer Testing Time Tissue Procurements Tissue Sample Tissues Tonsil Training United States National Institutes of Health Vaccines Validation Viral Load result Visit Woman chemokine cohort cytokine gastrointestinal innovation interest investigator training microbicide mucosal site novel rectum/anus research study response sample collection virology

项目摘要

The Mucosal Immunology Core Laboratory (MICL) was first proposed and funded in 1998 due to an emerging awareness that mucosal lymphoid tissues were critically important as a reservoir for HIV infection. To our knowledge, this was the first Core facility of its kind in CFAR and continues to be a unique resource nationally. Interested researchers had little access to freshly acquired tissue and there were no validated assays for quantifying tissue HIV viral burden as well as other relevant mucosal immunologic and virologic markers. Since the start of the most recent CFAR renewal 4.5 years ago, the MICL has collected over 8000 mucosal tissue biopsies for study from 362 subjects. An additional 407 MICL encounters include 235 subject visits for screening, blood or semen donation without biopsies and 172 tissue specimens received from collaborators for assays or tissue specimens received from the Tissue Procurement Core Laboratory (TPCL). Also the MICL has supported 21 researchers (8 non-UCLA), 21 grant applications (16 funded), and during the past 2 years the MICL has developed a Clinical Trial Registry of 317 potential subjects for proactive recruitment as needed. This resource in unmatched anywhere and is a very unique CFAR resource for HIV investigators.

粘膜免疫学核心实验室 (MICL) 于 1998 年首次提出并得到资助，原因是人们逐渐认识到粘膜淋巴组织作为艾滋病毒感染的储存库至关重要。据我们所知，这是 CFAR 中第一个此类核心设施，并且仍然是一种独特的资源全国范围内。感兴趣的研究人员几乎无法获得新获得的组织，并且没有经过验证的用于量化组织 HIV 病毒负荷以及其他相关粘膜免疫学和病毒学的测定标记。自 4.5 年前开始最近一次 CFAR 更新以来，MICL 已收集了 8000 多个对 362 名受试者进行粘膜组织活检以供研究。另外 407 次 MICL 遭遇包括 235 名受试者进行筛查、不进行活检的血液或精液捐献以及从以下机构收到的 172 份组织样本从组织采购核心实验室收到的化验或组织标本的合作者（TPCL）。 MICL 还支持了 21 名研究人员（8 名非加州大学洛杉矶分校）、21 份资助申请（16 份获得资助）和在过去 2 年中，MICL 开发了一个包含 317 名潜在受试者的临床试验登记册根据需要主动招聘。该资源在任何地方都是无与伦比的，并且是非常独特的 CFAR 艾滋病毒调查人员的资源。