Development of Clinical Trial Matching Engine Technology to Accelerate Participan

开发临床试验匹配引擎技术以加速参与者

• 批准号: 8312411
• 负责人: Ryan Luce
• 金额: $ 13.79万
• 依托单位: CORENGI, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-05 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312411
• 关键词: Algorithms; Applications Grants; Awareness; Benchmarking; Client; Clinical; Clinical Research; Clinical Trials; Code; Communities; Comprehension; Data; Development; Diabetes Mellitus; Directories; Disease; Enrollment; Exclusion Criteria; Failure; Feedback; Funding; Goals; Grant; Health Personnel; Human Volunteers; Individual; Internet; Interview; Location; Marketing; Medical; Medical Research; Methods; Metric; National Center for Research Resources; Non-Insulin-Dependent Diabetes Mellitus; Online Systems; Participant; Patient Recruitments; Patients; Phase; Press Releases; Prevention; Process; Public Health; Published Directory; Qualifying; Qualitative Research; Questionnaires; Recruitment Activity; Research; Research Personnel; Resources; Science; Small Business Innovation Research Grant; Social Network; Surveys; Technology; Testing; Time; United States; United States National Institutes of Health; Visit; Work; base; commercialization; cost effective; data mining; design; disease diagnosis; experience; human subject; improved; inclusion criteria; information processing; interest; outreach; programs; response; social; success; tool; usability; volunteer; web site

DESCRIPTION (provided by applicant): Conducting and completing clinical trials relies on successful recruitment of enough patient volunteers, who are appropriate matches, for any given study. Corengi, Inc. has developed a technology platform that supports a dedicated website with a matching engine and clinical trials directory and accompanying widget that can be embedded online by third parties. The purpose is to enable individuals to quickly identify geographically close trials, which they may be qualified for. The current focus is on Type 2 diabetes (T2D) but the tools can be enhanced to cover other diseases/conditions. Accelerating participant recruitment for clinical trials is an important public health goal that is specifically called out as a research topic of interest by the NCRR in the NIH SBIR omnibus solicitation. For this SBIR Phase 1 grant, Corengi, Inc. proposes the creation of new analogous clinical trial matching engines. The first component is to identify 3 to 5 diseases/conditions for which to create new clinical trials matching engines. This will be done by conducting survey and interview research and analyzing public data. The results will be used to determine the specific diseases/conditions optimally suited for a matching engine. An analysis of the universe of available trials on clinicaltrials.gov will also help determine the best candidates. The second component is the design, programming, and release of the new analogous matching engines. These efforts will build upon the Corengi team's experience in their development of the T2D engine. A medical questionnaire that the average patient can use and is effective at filtering the trials for each disease/condition will be designed for each of the new engines. New data import processes for the clinicaltrials.gov-based trial information will be developed and the criteria tex for each trial will be data mined and the appropriate algorithms coded. At this point, the new matching engines will be completed. The third component is to publicly release the new applications, analyze the resultant website metrics/user responses, and determine the commercialization potential. Press releases, social media integration, and search engine and social network marketing will be used to increase awareness of the matching tools. Research and feedback about the new engines will be correlated with the initial work done with T2D. The Corengi team has already demonstrated its ability to deliver a powerful T2D clinical trial matching engine, which has been well received by online diabetes communities and audiences. The company has taken successful initial steps in commercializing this product. Based on the firm's success to date and the ongoing public health need for patient volunteer recruitment to advance medical research, the NIH would be well- served to fund this SBIR Phase 1 grant proposal. PUBLIC HEALTH RELEVANCE: Corengi, Inc. has developed a technology platform, whose purpose is to enable individuals to quickly identify geographically close trials, which they may be qualified for, that supports a dedicated website with a matching engine and clinical trials directory and accompanying widget that can be embedded online by third parties. The current focus is on Type 2 diabetes but the tools can be enhanced to cover other diseases/conditions. This project proposal is to identify other diseases/conditions that may be suited to similar online resources, program the new applications, and analyze their impact on clinical trials recruitment by connecting a broader range of patients with clinical research.

描述（由申请人提供）：进行和完成临床试验依赖于成功招募足够的患者志愿者（适当的匹配者），以进行任何给定的研究。 Corengi，Inc。开发了一个技术平台，该技术平台支持一个专门的网站，该网站具有匹配的引擎和临床试验目录以及随附的小部件，该网站可以由第三方在线嵌入。目的是使个人能够快速识别地理上的封闭试验，他们可能有资格获得资格。当前的重点是2型糖尿病（T2D），但可以增强工具以涵盖其他疾病/疾病。 加速参与者招募临床试验是一个重要的公共卫生目标 NCRR在NIH SBIR综合招标中被称为研究主题。对于SBIR 1阶段赠款，Corengi，Inc。提议创建新的类似临床试验匹配引擎。 第一个组成部分是识别3至5种疾病/条件，以创建新的临床试验匹配引擎。这将通过进行调查和访谈研究和分析公共数据来完成。结果将用于确定最适合匹配引擎的特定疾病/条件。对ClinicalTrials.gov的可用试验宇宙的分析也将有助于确定最佳候选人。 第二个组件是新的类似匹配引擎的设计，编程和发布。这些努力将基于Corengi团队在T2D发动机开发方面的经验。普通患者可以使用并有效地过滤每种疾病/状况的试验的医学问卷将为每个新发动机设计。将开发基于临床的新数据导入过程。基于GOV的试验信息，每个试验的标准TEX将进行数据挖掘，并编码适当的算法。此时，新的匹配引擎将完成。 第三个组件是公开发布新应用程序，分析结果网站指标/用户响应，并确定商业化潜力。新闻稿，社交媒体集成以及搜索引擎和社交网络营销将用于提高对匹配工具的认识。有关新发动机的研究和反馈将与T2D进行的最初工作有关。 Corengi团队已经证明了其提供强大的T2D临床试验匹配引擎的能力，在线糖尿病社区和受众群体受到了很好的接待。该公司在商业化该产品方面已采取了成功的初步步骤。基于该公司迄今为止的成功以及持续的公共卫生需要志愿招募来推进医学研究的需求，NIH将为这一SBIR 1阶段授予的提案提供资金。 公共卫生相关性：Corengi，Inc。开发了一个技术平台，其目的是使个人能够快速识别地理位置近距离试验，他们可能是他们可能是 有资格获得的，它支持一个专门的网站，该网站具有匹配的引擎和临床试验目录以及随附的小部件，该网站可以由第三方在线嵌入。当前的重点是2型糖尿病，但可以增强工具以涵盖其他疾病/疾病。该项目建议是确定可能适合在线类似的其他疾病/疾病 资源，对新应用程序进行编程，并通过将更广泛的患者与临床研究联系起来，分析其对临床试验招聘的影响。