The Influence of Diet and Lifestyle on Patients with Advanced Colorectal Cancer

饮食和生活方式对晚期结直肠癌患者的影响

• 批准号: 8264385
• 负责人: JEFFREY A MEYERHARDT
• 金额: $ 62.48万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264385
• 关键词: Address; Area; Aspirin; Blood specimen; Body mass index; C-Peptide; Cancer Biology; Cancer Patient; Cancer and Leukemia Group B; Cardiovascular system; Cetuximab; Characteristics; Colon Carcinoma; Colorectal Cancer; Combination Drug Therapy; Comorbidity; Data; Databases; Development; Diagnosis; Diet; Dietary Intervention; Disease; Epidemiology; Epidermal Growth Factor Receptor; Future; Glycemic Index; Health Personnel; Human; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Integration Host Factors; Knowledge; Lead; Leptin; Life; Life Style; Malignant Neoplasms; Molecular; Mutate; NIH Program Announcements; National Cancer Institute; Neoplasm Metastasis; Newly Diagnosed; Non-Steroidal Anti-Inflammatory Agents; Obesity; Outcome; Paraffin Embedding; Pathway interactions; Patients; Pattern; Performance Status; Pharmaceutical Preparations; Physical activity; Plasma; Proteins; Proto-Oncogene Proteins c-akt; Recommendation; Research; Residual state; Risk; Specimen; Staging; Time; Toxic effect; Vitamin D; Vitamin D3 Receptor; abstracting; adiponectin; angiogenesis; bevacizumab; celecoxib; chemotherapy; cohort; cyclooxygenase 2; density; disease characteristic; energy balance; experience; follow-up; improved; indexing; lifestyle factors; lifestyle intervention; metastatic colorectal; mortality; outcome forecast; overexpression; pre-clinical; prevent; prospective; randomized trial; response; tumor; tumor growth; tumor progression

Project Summary/Abstract Epidemiologic and scientific research indicates that diet and other lifestyle factors have a significant influence on the risk of developing colorectal cancer. Emerging data suggest some of these factors impact on the outcomes of patients with early stage colon cancer. However, there are no data on the influence of diet, lifestyle and other host factors on the outcomes of patients with more advanced colorectal cancer. At the time of initial diagnosis, 20% of colorectal cancer patients have evidence of metastases and another 15- 20% will recur with metastatic disease within a few years of initial diagnosis. In the past 10 years, there have been substantial improvements in chemotherapy options for these patients, with median survival exceeding 2 years and increasing number of patients living 4 or more years. Patients often seek to understand what, if any, diet and lifestyle will improve their outcomes, both survival and tolerability of therapy. Moreover, how diet and lifestyle influence prognosis may depend, in part, on molecular characteristics of the tumor. In response to a NIH Program Announcement, PA-09-148, "Studies of Energy Balance and Cancer in Humans," we propose to address these gaps in knowledge by utilizing data from 2 National Cancer Institute-sponsored chemotherapy trials in newly diagnosed patients with stage IV colorectal cancer (CALGB 80203 and 80405) which provide a) prospective assessments of diet, medication, lifestyle and comorbidities; b) paraffin-embedded tumor specimens to examine how such factors interact with specific molecular alterations; c) blood samples for research purposes; and d) comprehensive data on cancer progression, mortality, and chemotherapy-related toxicity. Since stage, performance status, use of combination chemotherapy and follow-up were carefully defined in this trial, residual confounding by disease characteristics and use of chemotherapy should be minimized. This database will provide the unique opportunity to examine the influence of energy balance (Aim 1), diet and vitamin D (Aim 2) and aspirin/NSAIDs (Aim 3) on the outcomes of patients with advanced colorectal cancer. Beyond the aforementioned hypotheses, this cohort will allow for the rapid examination of future hypotheses as they emerge. Ultimately, this database will permit us to ascertain the influence of numerous factors on colorectal cancer survival, improve our understanding of colorectal cancer biology, and potentially offer substantive diet and lifestyle recommendations for patients and health care providers.

项目摘要/摘要 流行病学和科学研究表明，饮食和其他生活方式因素具有显着 对结直肠癌的风险的影响。新兴数据表明其中一些因素会影响 关于早期结肠癌患者的结果。但是，没有关于 饮食，生活方式和其他宿主因素关于更晚期结肠癌患者的结果。在 初始诊断的时间，有20％的大肠癌患者有转移的证据，另有15％ 20％将在初次诊断的几年内复发转移性疾病。在过去的10年中， 这些患者的化学疗法选择已大大改善，生存中位数 超过2年，居住4年或更长时间的患者数量增加。患者经常寻求 了解饮食和生活方式（如果有的话）会改善其成果，包括生存和耐受性 治疗。此外，饮食和生活方式如何影响预后可能部分取决于分子 肿瘤的特征。为了回应NIH计划公告，PA-09-148，“能源研究 在人类中的平衡与癌症，”我们建议通过利用来自2的数据来解决这些知识的差距 在新诊断的IV患者中，国家癌症研究所赞助的化学疗法试验 结直肠癌（CALGB 80203和80405），该癌症提供了饮食，药物，药物的前瞻性评估 生活方式和合并症； b）石蜡包裹的肿瘤标本，以检查这些因素如何相互作用 特定的分子改变； c）用于研究目的的血液样本； d）有关的全面数据 癌症的进展，死亡率和与化疗相关的毒性。自舞台，性能状态，使用 在此试验中仔细定义了联合化疗和随访，残留的混淆是由 疾病特征和化疗的使用应最小化。该数据库将提供 独特的机会来检查能量平衡的影响（AIM 1），饮食和维生素D（AIM 2）和 阿司匹林/NSAID（AIM 3）对晚结直肠癌患者的结局。超越 上述假设，该队列将允许对未来的假设进行快速检查 出现。最终，该数据库将允许我们确定众多因素对结直肠的影响 癌症的生存，提高我们对结直肠癌生物学的理解，并有可能提供实质性 为患者和医疗保健提供者提供饮食和生活方式建议。