Treating Youths With PTSD and Conduct Problems

治疗患有创伤后应激障碍和行为问题的青少年

• 批准号: 7470664
• 负责人: DANA K SMITH
• 金额: $ 15.26万
• 依托单位: OSLC COMMUNITY PROGRAMS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-19 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470664
• 关键词: Alcohol or Other Drugs use; Anxiety; Area; Award; Chronic; Clinical Research; Complement; Conduct Clinical Trials; Development; Female; Funding; Goals; Institutionalization; Instruction; Intervention; Intervention Studies; Intervention Trial; K-Series Research Career Programs; Knowledge; Measures; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Outcome; Phase; Post-Traumatic Stress Disorders; Problem behavior; Protocols documentation; Purpose; Rate; Recording of previous events; Research; Research Proposals; Review, Systematic (PT); Risk; Runaway Behavior; Sampling; Schools; Sex Behavior; Sleep; Specific qualifier value; Symptoms; Testing; Training; Training Activity; Trauma; Treatment Protocols; Youth; design; experience; girls; programs; size; skills; therapy development

DESCRIPTION (provided by applicant): The applicant is requesting 5 years of funding through the Mentored Career Development Award (K23) program to enhance her skills and knowledge in intervention research methodology with the ultimate goal of developing an independent program of research. The purpose of this award is to allow the applicant to build on her previous clinical and research experience indicating that female youths who have conduct problems have high rates of PTSD symptoms, which complicate treatment efforts. Specifically, the proposed training goals will provide specialized instruction and mentoring in the following areas: (1) the conduct of clinical trials, (2) intervention development for the integrated treatment of comorbid PTSD symptoms and conduct problems, (3) advanced statistical training in topics central to intervention research, and (4) training in the ethical conduct of research. The research plan is divided into three phases which complement the proposed sequence of training activities. During Phase I, the applicant will conduct a systematic review of existing assessments and interventions for treating PTSD. Under the guidance of mentors, assessments and interventions will be adapted for the treatment of PTSD symptoms with female youths who have comorbid conduct problems. During Phase II, the feasibility of the integrated intervention protocol will be tested on a small sample of female youths with comorbid PTSD symptoms and conduct problems. During Phase III, a small-scale pilot intervention trial will be conducted to test the integrated intervention protocol with a sample of female youths with comorbid PTSD symptoms and conduct problems. Each phase will build on previous phases, with the goal of producing a repeated assessment and an integrated intervention protocol for the treatment of PTSD symptoms in female youths who have comorbid conduct problems. Findings from the proposed research will be used to provide an effect-size estimate for the integrated treatment of comorbid PTSD symptoms and conduct problems, and ultimately, will provide the applicant with the knowledge and experience to pursue subsequent R01 applications and to expand this research to larger, more diverse samples.

描述（由申请人提供）：申请人请求通过导师职业发展奖（K23）计划获得 5 年的资助，以增强其在干预研究方法方面的技能和知识，最终目标是开发独立的研究计划。该奖项的目的是让申请人能够利用她之前的临床和研究经验，表明有品行问题的女性青少年出现创伤后应激障碍症状的比例很高，这使治疗工作变得复杂。具体而言，拟议的培训目标将在以下领域提供专门指导和指导：(1) 临床试验的进行，(2) 综合治疗 PTSD 共病症状和行为问题的干预措施开发，(3) 高级统计培训干预研究的核心主题；(4) 研究道德行为的培训。研究计划分为三个阶段，以补充拟议的培训活动顺序。在第一阶段，申请人将对治疗 PTSD 的现有评估和干预措施进行系统审查。在导师的指导下，将调整评估和干预措施，以治疗有共病行为问题的女性青少年的创伤后应激障碍症状。在第二阶段，将在一小部分患有 PTSD 症状和行为问题的女性青少年中测试综合干预方案的可行性。在第三阶段，将进行小规模试点干预试验，以患有 PTSD 症状和品行问题的女性青少年为样本，测试综合干预方案。每个阶段都将建立在前几个阶段的基础上，目标是制定重复评估和综合干预方案，以治疗患有共病行为问题的女性青少年的 PTSD 症状。拟议研究的结果将用于为合并 PTSD 症状和行为问题的综合治疗提供效果大小估计，并最终为申请人提供知识和经验，以追求后续的 R01 申请并将这项研究扩展到更大、更多样化的样本。