Neural Basis of Temporal Order Memory

时间顺序记忆的神经基础

• 批准号: 8235072
• 负责人: Wendy A. Suzuki
• 金额: $ 37.34万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235072
• 关键词: Address; Affect; Aging; Alzheimer' s Disease; Animals; Area; Behavior; Brain; Color; Computer Simulation; Cues; Disease; Dorsal; Employee Strikes; Episodic memory; Event; Foundations; Goals; Hippocampus (Brain); Impairment; Individual; Lateral; Learning; Maintenance; Medial; Memory; Memory Disorders; Memory impairment; Monitor; Nature; Pattern; Performance; Prefrontal Cortex; Process; Records Controls; Relative (related person); Retrieval; Role; Sampling; Schizophrenia; Series; Short-Term Memory; Signal Transduction; Site; Stimulus; Structure; Techniques; Temporal Lobe; Testing; Time; base; cognitive control; cognitive function; design; developmental disease; entorhinal cortex; extrastriate visual cortex; insight; long term memory; memory encoding; memory retrieval; neurophysiology; novel; prospective; public health relevance; relating to nervous system; research study; response; therapy development

Episodic memory is defined as detail-rich and flexibly accessible memory for individual events or episodes. A key component of episodic memory is memory for the temporal order of items within an episode. While it is clear that the structures of the medial temporal lobe (MTL) and the prefrontal cortex (PFC) both contribute to memory for temporally ordered information, the nature of that contribution and the interactions between these key brain areas during temporal order memory remains to be elucidated. Also unresolved is the relative contribution of these areas to working memory versus long-term memory tasks for temporally ordered information. The proposed experiments are based on the underlying hypothesis that the MTL and PFC contribute in complementary but differentiable ways to the performance of both working memory and long- term memory tasks for temporal order memory. To test these hypothesis, we will conduct a series of hypothesis driven experiments designed to define the specific contributions and interactions of structures in the MTL and PFC during temporal order tasks requiring either working memory or long-term memory retrieval. In Specific Aim 1, we will record activity in the MTL and PFC both individually and simultaneously as animals perform a working memory temporal order memory task with objects. In Specific Aim 2, we will record simultaneously across both areas as animals perform a task requiring long-term memory for color-cue - temporal order associations. For both Aims, cross correlation analyses as well as LFP and spike-field coherence analyses will allow us to evaluate the timing and the nature of the interactions between these areas. Specifically, we predict that a major role of the MTL, mainly through the activity of the hippocampus, is to provide strong signals for particular trial events and trial timing during both the WM and the LTM versions of the temporal order task. In addition, we predict that the surrounding entorhinal and perirhinal cortex are engaged in mnemonic encoding of object and object-temporal order conjunctions for the working memory task and the perirhinal cortex is critical for the retrieval of the long-term memory for associations between color-cues and temporal order. In contrast, we hypothesize that the PFC is primarily involved in cognitive control processes including a prominent role in maintenance of temporal order information during the working memory delay period, though we may see trial timing-related activity in the PFC as well Understanding the specific contributions and functional interactions of the MTL and PFC in temporal order memory will not only provide new insight into the fundamental cognitive function of episodic memory, but also has important implications for the development of treatments for a wide variety of disease states that affect episodic memory including Alzheimer's disease, schizophrenia, and the memory impairments present in aging.

情节内存定义为单个事件或 情节。情节内存的关键组成部分是内存的内存 插曲。虽然很明显，内侧颞叶（MTL）和前额叶的结构 Cortex（PFC）都有助于记忆的时间订购信息，其性质 在时间顺序记忆中，这些关键大脑区域之间的贡献和相互作用 尚待阐明。这些领域对工作的相对贡献也未解决 记忆与长期记忆任务的时间订购信息。提议 实验是基于基本假设，即MTL和PFC在 互补但可不同的方法来表现工作记忆和长期 时间订单内存的术语内存任务。为了检验这些假设，我们将进行一系列 假设驱动的实验，旨在定义特定的贡献和相互作用 在需要工作内存或 长期记忆检索。在特定的目标1中，我们将在MTL和PFC中记录活动 当动物执行工作记忆时间订单记忆任务时，单独和同时同时进行 与对象。在特定的目标2中，我们将在动物执行时同时在两个区域记录 需要长期内存的任务 - 颜色提示 - 时间订单关联。对于两个目标， 跨相关分析以及LFP和Spike-Field相干分析将使我们能够 评估这些区域之间相互作用的时间和性质。具体来说，我们预测 MTL的主要作用，主要是通过海马活动来提供强大的 WM和LTM版本期间特定试验事件的信号和试验时间的信号 时间订单任务。此外，我们预测周围的内嗅和周围皮层是 从事对象和对象时期秩序连词的助记符编码 记忆任务和周围皮层对于检索长期记忆至关重要 颜色序列与时间顺序之间的关联。相反，我们假设PFC是 主要参与认知控制过程，包括在维持中的重要作用 在工作记忆延迟期间的时间订单信息，尽管我们可能会看到试用 PFC中与时间相关的活动以及了解特定贡献和功能 MTL和PFC在时间顺序内存中的相互作用不仅将提供新的见解 情节记忆的基本认知功能，但也对 开发影响情节记忆的多种疾病状态 包括阿尔茨海默氏病，精神分裂症和衰老中存在的记忆障碍。