Oxytocin regulation of social buffering following stress

催产素对压力后社会缓冲的调节

• 批准号: 8324842
• 负责人: Adam Steven Smith
• 金额: $ 3.69万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-03 至 2013-08-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324842
• 关键词: Adrenal Glands; Amygdaloid structure; Animal Model; Anti-Anxiety Agents; Anxiety; Area; Attenuated; Behavior; Behavioral; Biological Factors; Biological Models; Blood; Blood Pressure; Brain; Brain region; Breeding; Buffers; Cells; Cessation of life; Characteristics; Child; Corticosterone; Corticotropin; Corticotropin-Releasing Hormone; Data; Development; Divorce; Dose; Enzyme Immunoassay; Event; FOS gene; Female; Fluorescence; Glucocorticoids; Heart Rate; Human; Hydrocortisone; Immunohistochemistry; Individual; Label; Laboratories; Left; Life; Measures; Mediating; Mental Health; Mental disorders; Microdialysis; Microinjections; Microtus; Neurobiology; Neurons; Neuropeptides; Neurosecretory Systems; Neurotransmitters; Nucleus Accumbens; Occupations; Oxytocin; Oxytocin Receptor; Pair Bond; Panic Disorder; Patients; Phenotype; Pituitary Gland; Plasma; Process; Radioimmunoassay; Recovery; Regulation; Research; Risk; Rodent; Role; Sampling; Social Behavior; Social Interaction; Social support; Source; Spouses; Stress; Stressful Event; System; Testing; Therapeutic; Woman; Work; biobehavior; biological adaptation to stress; brain behavior; cohort; experience; hypothalamic-pituitary-adrenal axis; male; paraventricular nucleus; physical conditioning; prairie vole; preference; programs; psychological distress; putamen; response; restraint stress; social; stress management; stressor

DESCRIPTION (provided by applicant): Social support following a stressful life event can attenuate stress response systems, such as the activation of the hypothalamic-pituitary-adrenal (HPA) axis, and reduce the odds of psychological distress or a panic disorder; this is known as social buffering. This is particularly true when support is derived from a social partner (e.g., spouse). However, biological factors that are involved with social support and their influence on the HPA axis following a stressful event are understudied due to the lack of appropriate animal models that can examine support from a social partner. The pair-bonding behavior in monogamous prairie voles (Microtus ochrogaster) is well characterized and represents a unique model system to study brain-behavior relationships. This proposal will use prairie voles as a model system to identify neuroendocrine mechanisms of social support following a stressful experience, particularly the mediating effects of the neuropeptide oxytocin (OT). The prairie vole is a highly social, monogamous rodent that breeds readily in captivity and forms a long-term social preference for their partner, a traditional characteristic of pair-bond formation. Like humans, contact with a social partner can attenuate the behavioral and HPA axis response to a stressful event. In addition, positive social interactions promote brain OT release in prairie voles, and OT release in the hypothalamic paraventricular nucleus (PVN) - which also contains corticotropin-releasing hormone neurons that project to the pituitary to control adrenocorticotropic hormone secretion and subsequent adrenal glucocorticoid release - attenuates stress reactivity. Therefore, prairie voles may serve as a unique model system to study the anxiolytic effects of interaction with a social partner following a stressful event and the potentially mediating role of OT. By using prairie voles in a social buffering stress paradigm, the results from this proposal should: (1) characterize the anxiolytic effects of interactions with a social partner and OT following a stressful event, (2) identify the role that OT has in the social buffering of the biobehavioral stress response, and (3) present neuronal phenotypes in several brain regions that are influenced by social interaction-induced OT release following a stressful experience. This research program represents several steps in examining the neurobiology mechanism underlying the social buffering effect in prairie voles.

描述（由申请人提供）：紧张的生活事件后的社会支持可以减轻压力反应系统，例如下丘脑 - 垂体 - 肾上腺（HPA）轴的激活，并减少心理困扰或恐慌症的几率；这就是社会缓冲。当从社会伙伴（例如配偶）获得支持时，尤其如此。但是，由于缺乏适当的动物模型，可以检查社会伴侣的支持，因此对社会支持及其对HPA轴的影响及其对HPA轴的影响进行了研究。一夫一妻制的草原田鼠（Microtus ochrogaster）的成对结构行为是很好的特征，它代表了研究脑行为关系的独特模型系统。该建议将使用草原田鼠作为模型系统，以识别紧张的经历后，尤其是神经肽氧毒素（OT）的介导作用，以识别社会支持的神经内分泌机制。草原田鼠是一种高度社交，一夫一妻制的啮齿动物，可以轻松地被囚禁，并构成对伴侣的长期社会偏好，这是成对形成的传统特征。像人类一样，与社会伙伴的接触可以减轻对压力事件的行为和HPA轴的响应。此外，积极的社会相互作用促进了大草原田鼠中的大脑OT释放，以及在下丘脑旁脑室核（PVN）中释放的OT释放 - 它还包含释放皮质激素释放的激素神经元，这些激素神经元投射到垂体上，以控制肾上腺皮质激素分泌和肾上腺肾上腺胶状效应。因此，草原田鼠可以作为一个独特的模型系统，以研究压力大事件和OT的潜在中介作用后，研究与社会伴侣相互作用的抗焦虑作用。 By using prairie voles in a social buffering stress paradigm, the results from this proposal should: (1) characterize the anxiolytic effects of interactions with a social partner and OT following a stressful event, (2) identify the role that OT has in the social buffering of the biobehavioral stress response, and (3) present neuronal phenotypes in several brain regions that are influenced by social interaction-induced OT release following a stressful experience.该研究计划代表了研究草原田鼠社会缓冲效应的神经生物学机制的几个步骤。