Quantitative Chemical Biology(RMI)

定量化学生物学(RMI)

基本信息

批准号：
7483705
负责人：
TOBIAS MEYER
金额：
$ 26.84万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2010-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7483705
关键词：
Academia Active Sites Address Admission activity Advisory Committees Algorithms Amino Acid Sequence Anabolism Area Award Belief Binding Biochemical Biochemistry Bioinformatics Biological Biology Biomedical Research California Categories Cell Communication Cell Lineage Cell physiology Cells Characteristics Chemicals Chemistry Chromosome Mapping Class Cluster Analysis Collaborations Commit Committee Members Communities Complex Computational Biology Computing Methodologies Consultations Country Critiques DNA DNA Structure Data Development Developmental Biology Developmental Process Diffusion Discipline Doctor of Philosophy Educational Curriculum Educational process of instructing Educational workshop Embryo Embryonic Development Ensure Environment Enzymes Equation Equilibrium Esthetics Evaluation Event Evolution Exercise Experimental Designs Faculty Failure Feedback Figs - dietary Fostering Foundations Fourier Series Funding Future Genetic Genetic Polymorphism Genetic Recombination Genome Genomics Goals Grant Group Meetings Growth Hand Haplotypes Home environment Homeostasis Hormonal Humanities Immunology Individual Industry Inorganic Chemistry Insecta Institutes Institution Interdisciplinary Study Journals Kinetics Knowledge Laboratories Laboratory Research Laws Lead Leadership Learning Left Legal patent Life Ligands Linear Programming Location Mammals Markov Chains Mathematics Membrane Mentors Mentorship Metalloproteins Metals Methods Modeling Molecular Molecular Models Monitor National Institute of General Medical Sciences Nature Nematoda Neurosciences Nucleotides Numbers Object Attachment Oral Oral Examination Organic Chemistry Organism Oxidation-Reduction Paper Participant Pathway interactions Peptide Sequence Determination Performance Persons Pharmacology Phosphorylation Physics Positioning Attribute Postdoctoral Fellow Principal Investigator Process Progress Reports Property Proteins Proteolysis Purpose Pyridoxal Qualifying Range Reaction Reading Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Proposals Resources Role Rotation Safety San Francisco Schedule Schools Science Scientist Sequence Analysis Series Services Signal Transduction Signal Transduction Pathway Site Solutions Solvents Staging Standards of Weights and Measures Statistical Models Structure Students Suggestion Synthesis Chemistry System Systems Biology Techniques Testing Thermodynamics Thinking Time Time Management Today Training Training Programs Training Support Tumor Biology Universities Update Visit Week Work Writing base biological research career chemical bond chemical synthesis cofactor computer science concept day design electrical potential experience falls frontier gene therapy genetic manipulation genome database genome sequencing improved innovation instructor interest macromolecule mathematical model medical schools member molecular dynamics molecular orbital next generation parent grant peer post-doctoral training posters practical application pre-doctoral programs prospective reconstruction solute statistics structural biology symposium theories tool

项目摘要

DESCRIPTION (provided by applicant): Quantitative and chemical approaches to biomedical science are becoming increasingly important in the post-genomic era. Through the completion of multiple sequencing efforts, the scientific community has a panoramic view of nature's genetic 'parts', and it is now challenged with acquiring a functional knowledge of this complex machinery. Achieving this goal will require innovative approaches to biomedical research, and our next generation of scientists will therefore need training that seamlessly integrates quantitative, chemical, and biological methods. This application describes plans by Stanford University to create the Quantitative Chemical Biology (QCB) Program, an interschool initiative that will train predoctoral and postdoctoral students in interdisciplinary research. The QCB Program will be organized around several modules that include an interdepartmental graduate training program, a QCB Fellows program, specialized coursework, seminars and symposia, and two QCB faculty-directed facilities that will support post-genomic research projects. These activities and resources will establish a new paradigm for training young scientists, while synergizing with current programs at Stanford, such as the Bio-X initiative for multidisciplinary research. The University's ultimate goal is the creation of an interdepartmental, degree-granting QCB Program. In the interim, the Program will target students admitted to the Departments of Molecular Pharmacology and Chemistry who demonstrate an interest in interdisciplinary research, providing them with unrestricted access to nineteen QCB-affiliated laboratories in six academic departments. The QCB Program will also sponsor postdoctoral fellows who work collaboratively with two or more QCB-affiliated faculty members. Through these mechanisms, the QCB Training Program will support a diverse community that fosters interdisciplinary research and collaborative discovery, preparing future scientists for a scientific landscape without boundaries.

描述（由申请人提供）：在后基因组时代，生物医学的定量和化学方法变得越来越重要。通过完成多次测序工作，科学界对自然界的遗传“部分”有了全景了解，现在面临的挑战是获取这一复杂机制的功能知识。实现这一目标需要创新的生物医学研究方法，因此我们的下一代科学家将需要无缝整合定量、化学和生物方法的培训。该申请描述了斯坦福大学创建定量化学生物学（QCB）计划的计划，这是一项校际计划，旨在培训博士前和博士后学生进行跨学科研究。 QCB 计划将围绕多个模块进行组织，其中包括跨部门研究生培训计划、QCB 研究员计划、专业课程、研讨会和座谈会，以及两个由 QCB 教师指导的设施，以支持后基因组研究项目。这些活动和资源将为培训年轻科学家建立一个新的范式，同时与斯坦福大学当前的项目（例如用于多学科研究的 Bio-X 计划）产生协同作用。该大学的最终目标是创建一个跨部门、授予学位的 QCB 项目。在此期间，该计划将针对那些对跨学科研究表现出兴趣的分子药理学和化学系录取的学生，为他们提供不受限制地进入六个学术部门的 19 个 QCB 附属实验室的机会。 QCB 计划还将资助与两名或更多 QCB 附属教员合作工作的博士后研究员。通过这些机制，QCB 培训计划将支持多元化的社区，促进跨学科研究和协作发现，为未来的科学家迎接无边界的科学领域做好准备。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.

GCC185 中的多个 Rab GTP 酶结合位点表明了反高尔基体处囊泡束缚的模型。

DOI：
发表时间：
2009-01
期刊：
影响因子：
3.3
作者：
Hayes, Garret L;Brown, Frank C;Haas, Alexander K;Nottingham, Ryan M;Barr, Francis A;Pfeffer, Suzanne R
通讯作者：
Pfeffer, Suzanne R