Vestibular thresholds, including psychophysical response dynamics

前庭阈值，包括心理物理反应动力学

基本信息

批准号：
8306313
负责人：
Daniel M Merfeld
金额：
$ 54.68万
依托单位：
MASSACHUSETTS EYE AND EAR INFIRMARY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8306313
关键词：
Acceleration Address Age Animals Audiometry Basic Science Behavior Bilateral Biological Assay Brain Characteristics Clinical Coupled Cues Data Detection Diagnosis Discontinuous Capillary Disease Frequencies Goals Head Human Investigation Knowledge Lead Macaca mulatta Measures Methodology Methods Modeling Monkeys Motion Motion Perception Noise Patients Perception Play Positioning Attribute Posture Procedures Process Psychophysiology Reflex action Reporting Research Research Design Role Rotation Sensory Sensory Process Signal Detection Analysis Stimulus Symptoms System Testing Theoretical model Translations Vision Visual Visual Acuity Yaws base behavior measurement clinically relevant design experience neglect neuromechanism otoconia public health relevance relating to nervous system research clinical testing research study response sensory integration sensory system statistics theories vestibulo-ocular reflex

项目摘要

DESCRIPTION (provided by applicant): Recent studies have shown that reflexes and perception evoked by vestibular cues can utilize qualitatively different mechanisms; yet there is a paucity of knowledge regarding vestibular perception. This may be why large percentages of vestibular patients report perceptual deficits that are undiagnosed. Regardless of explanation, the underlying causes of many perceptual deficits are not diagnosed. With the exception of the subjective visual vertical test, quantitative clinical tests focus exclusively on reflexive responses. However, the best way to assay undiagnosed motion perception symptoms is via perceptual testing. Therefore, the clinical goal for the research proposed herein is to establish precise efficient methods to quantify motion perception in general and, more specifically, to assay perceptual thresholds. To achieve these clinical goals, we propose patient testing alongside basic science studies. Specifically, one basic science goal of this proposal is to determine thresholds for rotation, translation, and tilt as functions of frequency. To our surprise, tilt thresholds evoked by dynamic tilt stimuli have never been reported. Furthermore, our knowledge of rotation and translation thresholds as a function of frequency - crucial both for clinical testing and for a scientific understanding of the dynamics of vestibular perception - is limited. Using threshold tests, we also propose to study another fundamental characteristic of vestibular perception. Specifically we propose to study the coordinate frame(s) utilized for motion perception. While we focus on perception, we also propose to measure VOR thresholds. To accomplish all of the above goals, we propose a comprehensive set of studies using patients, monkeys, and "normals" to achieve the following specific aims: SA 1. Measure perceptual thresholds in "normal" humans for A) rotations about an earth-vertical axis (canal only), B) for translations (otolith only), and C) for tilts (canal & otolith) across a wide range of frequencies. SA 2. Measure both perceptual and VOR thresholds for yaw rotation (canal only), inter-aural translation (otolith only) and roll tilt (canal and otolith) in rhesus monkeys. SA 3. Measure perceptual thresholds for rotation, translation, and tilt in patients suffering known vestibular disorders. PUBLIC HEALTH RELEVANCE: Large percentages of vestibular patients report perceptual deficits (e.g., illusory sway motions) that are undiagnosed. With the exception of the subjective visual vertical test, which assays integration of static visual and static tilt cues, quantitative clinical tests focus exclusively on reflexive responses (e.g., posture, VOR, etc.). It seems likely that the best way to assay undiagnosed motion perception symptoms is via perceptual testing using dynamic motion stimuli. Therefore, the clinical goal for the research proposed herein is to establish precise efficient methods to quantify motion perception in general and, more specifically, to assay perceptual thresholds.

描述（由申请人提供）：最近的研究表明，前庭提示引起的反射和感知可以利用定性不同的机制。然而，关于前庭感知的知识很少。这可能就是为什么大部分的前庭患者报告未诊断的感知缺陷的原因。不管有何解释，许多知觉缺陷的根本原因均未诊断出来。除主观视觉垂直测试外，定量临床测试仅着眼于反射反应。但是，测定未诊断运动感知症状的最佳方法是通过感知测试。因此，本文提出的研究的临床目标是建立精确的有效方法，以量化运动感知一般，更具体地说，更具体地说，以分析感知阈值。为了实现这些临床目标，我们建议与基础科学研究一起进行患者测试。具体而言，该提案的一个基本科学目标是确定旋转，翻译和倾斜作为频率功能的阈值。令我们惊讶的是，从未报道过动态倾斜刺激引起的倾斜阈值。此外，我们对旋转和翻译阈值的了解是频率的函数 - 对于临床测试和对前庭感知动力学的科学理解至关重要。使用阈值测试，我们还建议研究前庭感知的另一个基本特征。具体而言，我们建议研究用于运动感知的坐标框架。尽管我们专注于感知，但我们还建议测量阈值。 To accomplish all of the above goals, we propose a comprehensive set of studies using patients, monkeys, and "normals" to achieve the following specific aims: SA 1. Measure perceptual thresholds in "normal" humans for A) rotations about an earth-vertical axis (canal only), B) for translations (otolith only), and C) for tilts (canal & otolith) across a wide range of frequencies. SA 2。测量偏航旋转（仅运河），耳朵间翻译（仅耳石）的感知和VOR阈值，以及恒河猴中的倾斜倾斜（运河和耳石）。 SA 3。测量患有已知前庭疾病的患者的旋转，翻译和倾斜的感知阈值。公共卫生相关性：大部分的前庭患者报告了未诊断的知觉缺陷（例如，虚幻的摇摆动作）。除了主观视觉垂直测试（测定静态视觉和静态倾斜提示）的主观视觉垂直测试外，定量临床测试仅关注反射反应（例如姿势，VOR等）。测定未诊断运动感知症状的最佳方法似乎是使用动态运动刺激进行感知测试。因此，本文提出的研究的临床目标是建立精确的有效方法，以量化运动感知一般，更具体地说，更具体地说，以分析感知阈值。