Electrophysiological and psychophysical measures of auditory temporal processing

听觉时间处理的电生理学和心理物理学测量

• 批准号: 8316802
• 负责人: Sara K. Mamo
• 金额: $ 5.91万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-09 至 2015-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316802
• 关键词: Acoustics; Address; Affect; Age; Age-associated memory impairment; Aging; Aging-Related Process; Auditory; Auditory Brainstem Responses; Auditory system; Brain Stem; Burn injury; Characteristics; Clinical; Clinical assessments; Code; Cognitive; Complement; Complex; Cueing for speech; Cues; Data Analyses; Detection; Ear; Elderly; Evaluation; Evoked Potentials; Evoked Potentials, Auditory, Brain Stem; Exhibits; Frequencies; Generations; Goals; Hearing; Investigation; Knowledge; Masks; Measures; Mentorship; Methods; Modeling; Noise; Pattern; Performance; Periodicity; Phase; Population; Process; Psychophysiology; Research; Research Design; Sensory; Signal Transduction; Simulate; Speech; Speech Perception; Speech Sound; Stimulus; Testing; Training Programs; Translating; age related; aging population; base; clinically relevant; cognitive change; computerized data processing; design; experience; improved; indexing; interest; relating to nervous system; research study; response; sound; speech processing; tool; young adult; Acoustics; Address; Affect; Age; Age-associated memory impairment; Aging; Aging-Related Process; Auditory; Auditory Brainstem Responses; Auditory system; Brain Stem; Burn injury; Characteristics; Clinical; Clinical assessments; Code; Cognitive; Complement; Complex; Cueing for speech; Cues; Data Analyses; Detection; Ear; Elderly; Evaluation; Evoked Potentials; Evoked Potentials, Auditory, Brain Stem; Exhibits; Frequencies; Generations; Goals; Hearing; Investigation; Knowledge; Masks; Measures; Mentorship; Methods; Modeling; Noise; Pattern; Performance; Periodicity; Phase; Population; Process; Psychophysiology; Research; Research Design; Sensory; Signal Transduction; Simulate; Speech; Speech Perception; Speech Sound; Stimulus; Testing; Training Programs; Translating; age related; aging population; base; clinically relevant; cognitive change; computerized data processing; design; experience; improved; indexing; interest; relating to nervous system; research study; response; sound; speech processing; tool; young adult

DESCRIPTION (provided by applicant): The long-term aim of this project is to determine the relationship between temporal processing deficits apparent in the brainstem response to complex acoustic cues and speech perception difficulties in noisy backgrounds. The specific objective of the proposed research is to characterize the brainstem encoding of speech and other complex stimuli in young and older adults. The proposed experiments are designed to compare younger and older listeners with near-normal audiometric hearing in order to understand how reduced fidelity of temporal processing affects encoding of the temporal components of speech and, consequently, speech perception. Aim 1 will employ auditory brainstem response measures elicited by speech as an index of periodicity coding. This study will test the primary hypothesis that the degree of periodicity coding measured at the level of the brainstem is dependent on stimulus duration. Aim 2 will model temporal deficits exhibited in the aging auditory system by estimating a measure of 'internal noise' for the older adults. This study will rely on an evaluation of the brainstem response elicited by speech stimuli that has been corrupted using a temporal jitter model. Aim 3 will relate the electrophysiological measures to psychophysical and speech perception measures in young and older adults. Both the psychophysical task (detection of dichotic low-rate frequency modulation) and the speech task (modulation masking release) are designed to capture aspects of temporal processing. The training program involves strong mentorship in research design, especially in the domain of signal processing (stimulus generation, response analysis, etc.) and data analysis essential to the proposed research. Results will contribute to a more refined understanding of sub-cortical processing of speech sounds and the effects of temporal processing deficits on speech processing. The translational emphasis of this project is to optimize the use of complex-ABR measures for the assessment of clinical populations who experience difficulty perceiving speech despite audiometrically normal hearing. PUBLIC HEALTH RELEVANCE: Speech-evoked auditory brainstem responses have been used to investigate auditory processing in a variety of clinical populations. This project will advance our understanding of how these responses depend on the characteristics of the speech sound as well as on the integrity of temporal processing in the affected ear. Project results will have direct clinical relevance in terms of the use of speech-evoked auditory brainstem responses in the assessment of populations with speech perception difficulties.

描述（由申请人提供）：该项目的长期目的是确定脑干对复杂的声明提示和语音感知困难在嘈杂的背景下对脑干响应显而易见的关系之间的关系。拟议研究的具体目标是表征年轻和老年人中语音和其他复杂刺激的脑干编码。所提出的实验旨在将年轻听众和年龄较大的听众听力进行比较，以了解时间处理的忠诚度如何影响语音的时间成分的编码，从而影响语音感知。 AIM 1将采用听觉脑干响应措施通过语音引起的定期编码索引。这项研究将检验主要假设，即定期编码程度在 脑干取决于刺激持续时间。 AIM 2将通过估计老年人的“内部噪声”度量来模拟在老化听觉系统中表现出的时间缺陷。这项研究将依靠对使用时间抖动模型损坏的语音刺激引起的脑干反应的评估。 AIM 3将将电生理措施与年轻人和老年人的心理物理和语音感知措施联系起来。心理物理任务（检测到二分法低速频率调制）和语音任务（调制掩蔽释放）均旨在捕获时间处理的各个方面。该培训计划涉及研究设计方面的强大指导，尤其是在信号处理（刺激产生，响应分析等）的领域和对拟议研究必不可少的数据分析中。结果将有助于对语音语音的亚皮质处理以及时间处理缺陷对语音处理的影响有更精致的了解。该项目的转化重点是优化使用复杂的ABR措施来评估尽管听力正常的听力正常，但临床人群的评估却难以感知语音。 公共卫生相关性：言语诱发的听觉脑干反应已用于调查各种临床人群中的听觉处理。该项目将促进我们对这些响应如何取决于语音的特征以及受影响耳朵中时间处理的完整性的理解。项目结果将在使用语音感知困难的人群评估中使用言语引起的听觉脑干反应的直接临床相关性。