Biostatistics and Bioinformatics

生物统计学和生物信息学

• 批准号: 8561359
• 负责人: BRIAN JOSEPH SMITH
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-20 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8561359
• 关键词: Adverse event; Archives; Area; Basic Science; Bioinformatics; Biometry; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Comprehensive Cancer Center; Computational Biology; Correlative Study; Country; Data; Data Analyses; Data Collection; Databases; Development; Disease; Epidemiologic Studies; Funding; Gene Mutation; Genes; Genomics; Genotype; Human; Human Resources; Immunologics; Informatics; Information Management; Laboratories; Link; Lymphoma; Malignant Neoplasms; Manuscripts; Monitor; Nature; Online Systems; Preparation; Procedures; Process; Quality Control; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Site; Specialized Program of Research Excellence; System; Testing; Time; Universities; abstracting; data management; design; innovation; member; research study

The Biostatistics and Bioinformatics Core (Biostats Core) provides collaborative statistical and informatics support to the UI/MC SPORE projects, developmental projects, and other cores. The comprehensive nature ofthe Core, which will have activities at both lowa and Maye, assures each SPORE investigator access to expertise that includes development of study designs and analysis plans, state of the art data analysis and interpretation, data management resources, and abstract and manuscript preparation. The Core builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one ofthe largest statistical groups in the country whose members have collaborated on more than 8,000 clinical and basic science research studies since 1966, as well as the University of lowa Holden Comprehensive Cancer Center, Biostatistics Department, and Coordinated Laboratory fer Computational Genomics. Design and analysis support will be provided across a range of fields, including epidemiological studies, basic sciences including translational and immunologic correlative studies, gene microarray, gene and mutation discovery, expression analysis and genomics, and computational biology. The Core developed the statistical plans for past studies initiated in the SPORE, and has been actively involved in the preparation of statistical plans for the four projects in this application. Support is also provided for the management and integration ef existing and newly collected data through consistent and compatible data handling. Areas of support include database development, data form development and processing, data collection and entry, data archiving, quality control, and management of information relating to gene mutation identification and genotyping data for disease linkage experiments. In the past funding periods, the Cere established the infrastructure te link lymphoma clinical and research databases between Ul and MC. This system is fully functional and allows web-based clinical registration and data entry from both sites into a common database. Furthermore, the Core has and will continue to provide data management for all studies, to monitor adverse events In conjunction with the Clinical Research Core, and to prepare data summaries for manuscript preparation. In summary, strengths of the Biostatistics and Bioinformatics Core are our collaboration with each of the projects and cores, the ability to utilize the established centralized research database as well as the operational and statistical infrastructure already in place in the SPORE, and the breadth of expertise provided by Biostatistics and Bioinformatics personnel.

生物统计学和生物信息学核心（Biostats Core）提供协作统计和信息学 支持 UI/MC SPORE 项目、开发项目和其他核心。综合性 ofthe Core 将在 lowa 和 Maye 开展活动，确保每个 SPORE 调查员都能访问 专业知识，包括制定研究设计和分析计划、最先进的数据分析和 解释、数据管理资源以及摘要和手稿准备。核心建立在 由梅奥诊所（Mayo Clinic）开发的创新且经过时间考验的程序和系统，梅奥诊所是最大的诊所之一 该国统计小组的成员已合作开展了 8,000 多项临床和基础研究 自1966年以来的科学研究，以及洛瓦霍顿大学综合癌症 中心、生物统计系和计算基因组学协调实验室。设计与 将在流行病学研究、基础科学等一系列领域提供分析支持 包括转化和免疫学相关研究、基因微阵列、基因和突变发现， 表达分析和基因组学以及计算生物学。核心制定了统计计划 过去在 SPORE 发起的研究，并一直积极参与统计计划的制定 此应用程序中的四个项目。还为现有的管理和集成提供支持 以及通过一致且兼容的数据处理新收集的数据。支持领域包括 数据库开发、数据表单开发和处理、数据收集和输入、数据归档、 基因突变鉴定和基因分型数据相关信息的质量控制和管理 用于疾病连锁实验。在过去的资助期间，Cere 建立了基础设施 te link Ul 和 MC 之间的淋巴瘤临床和研究数据库。该系统功能齐全，允许 基于网络的临床注册并将两个站点的数据输入到一个公共数据库中。此外， Core 已经并将继续为所有研究提供数据管理，以监测不良事件 与临床研究核心结合，并为稿件准备准备数据摘要。在 总之，生物统计学和生物信息学核心的优势在于我们与每个领域的合作 项目和核心，利用已建立的集中研究数据库以及 SPORE 已具备运营和统计基础设施以及广泛的专业知识 由生物统计学和生物信息学人员提供。