Ovarian Cancer: Prevention of the Disease and Its Recurrence

卵巢癌：预防疾病及其复发

• 批准号: 8256799
• 负责人: Robert Page Edwards
• 金额: $ 1万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256799
• 关键词: Advocate; Area; Bilateral oophorectomy; CA-125 Antigen; Cause of Death; Cessation of life; Chemopreventive Agent; Detection; Development; Diagnosis; Discipline; Disease; Early Diagnosis; Family; Foundations; Fright; Funding; Genetic; Goals; Gynecologic; High Risk Woman; Immunology; Incidence; Knowledge; Learning; Life; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Methods; Modality; Molecular; Morbidity - disease rate; Nature; Operative Surgical Procedures; Oral Contraceptives; Outcome; Ovarian; Participant; Personal Satisfaction; Policy Maker; Premalignant; Prevention; Preventive; Primary Prevention; Procedures; Recurrence; Research; Risk; Scientist; Screening procedure; Secondary Prevention; Series; Slide; Staging; Structure; Summary Reports; Survival Rate; Techniques; Technology; Time; Transvaginal Ultrasound; Virulent; Woman; Women' s Health; advanced disease; anticancer research; base; chemotherapy; disorder later incidence prevention; disorder prevention; high throughput technology; innovation; meetings; mortality; novel; outcome forecast; ovarian cancer prevention; prevent; success; symposium; tertiary prevention

DESCRIPTION (provided by applicant): Ovarian cancer is the most common cause of death from gynecologic malignancy in the US, resulting in 13,850 deaths in 2010. Most women have advanced disease at diagnosis. Despite aggressive treatment, prognosis for these women is poor: 5-year survival is less than 30%. This poor outcome is due to the lack of effective prevention and early detection strategies: when diagnosed at an early stage, the survival rate is 85-90%. Thus, prevention and early detection are key to overcoming this disease. However, few preventive modalities exist and current screening techniques have failed to reduce morbidity or mortality. Thus, we urgently need to identify better prevention, detection and screening methods. Moreover, because of the virulent and usually fatal nature of the disease, most women with ovarian cancer live with fear of recurrence, which happens in ~85% of cases. Current treatments offer little hope, and research into preventing recurrence is limited. New methods to prevent, detect and treat recurrence are urgently needed. With NCI funding in 2002 & 2005, we hosted symposia on ovarian cancer, bringing together the world's experts on prevention of the disease and its recurrence from various scientific disciplines. The success and enthusiasm generated by those meetings underscore the need for periodic meetings focused on ovarian cancer. No other meetings of this type exist. We propose to organize biennial symposia to facilitate interactions among scientists from different disciplines, policy makers and consumer advocates so that progress can be made in overcoming this disease. The Specific Aim of the symposia series is to expand our understanding of and research in the underlying mechanisms in ovarian cancer, with a focus on applying that knowledge to prevention and early detection of the diseases and its recurrence. The NCI has made molecular and biologic mechanisms, high-throughput technologies, genetics, and targeted therapies key goals in FY2011, with ovarian cancer a focus area. Recent scientific and technological advances, together with the lack of periodic scientific meetings specifically on ovarian cancer, support the need for a series of symposia on innovative approaches to research in ovarian cancer. PUBLIC HEALTH RELEVANCE: Ovarian cancer is the leading killer among gynecologic cancers in women. Little progress has been made in overcoming this disease. There is no periodic scientific meeting focused on ovarian cancer research. A small, well-focused meeting to facilitate cross-talk among ovarian cancer experts from various disciplines who do not typically or consistently interact is a key step in making progress in overcoming this killer.

描述（由申请人提供）：卵巢癌是美国妇科恶性肿瘤最常见的死亡原因，2010年导致13,850例死亡。大多数妇女在诊断时患有患病。尽管有积极的治疗，但这些女性的预后还是很差的：5年生存率小于30％。这种不良结果是由于缺乏有效的预防和早期检测策略所致：在早期诊断时，生存率为85-90％。因此，预防和早期检测是克服这种疾病的关键。但是，很少有预防模式，当前的筛查技术未能降低发病率或死亡率。因此，我们迫切需要确定更好的预防，检测和筛选方法。此外，由于疾病的有毒且通常是致命的性质，大多数卵巢癌的女性害怕复发，这发生在约85％的病例中。当前的治疗几乎没有希望，并且对预防复发的研究受到限制。迫切需要进行预防，检测和治疗复发的新方法。借助2002年和2005年的NCI资助，我们举办了关于卵巢癌的研讨会，将世界预防疾病的专家汇集在一起​​，及其从各种科学学科中复发。这些会议产生的成功和热情强调了针对卵巢癌的定期会议的需求。没有其他这种类型的会议。我们建议组织两年一次的研讨会，以促进来自不同学科，政策制定者和消费者倡导者的科学家之间的互动，以便在克服这种疾病方面取得进展。研讨会系列的具体目的是扩大我们对卵巢癌潜在机制的理解和研究，重点是将知识应用于预防和早期发现疾病及其复发。 NCI在2011财年制定了分子和生物学机制，高通量技术，遗传学和靶向疗法的关键目标，而卵巢癌是焦点区域。最近的科学和技术进步，加上缺乏有关卵巢癌的定期科学会议，支持了一系列关于卵巢癌研究创新方法的研讨会的需求。 公共卫生相关性：卵巢癌是女性妇科癌的主要杀手。克服这种疾病几乎没有取得进展。没有定期的科学会议重点是卵巢癌研究。一次小型，专注的会议，旨在促进来自各个学科的卵巢癌专家的跨话，这些专家通常不或一贯互动是在克服这一杀手方面取得进步的关键一步。