Task Specific Project 2

任务特定项目 2

• 批准号: 8381292
• 负责人: Eva M. Sevick-Muraca
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8381292
• 关键词: Area; Back; Boxing; Canis familiaris; Collection; Color; Computers; Custom; Diagnostic; Dyes; Event; Extravasation; Fluoroscopy; Frequencies; Goals; Height; Image; Lasers; Light; Lighting; Malignant Neoplasms; Measurement; Medical; Molecular; Nodal; Nuclear; Operative Surgical Procedures; Phase; Process; Research Institute; Source; Staging; Surgeon; Surgical Instruments; System; Time; Width; Work; analog; arm; austin; base; charge coupled device camera; data acquisition; design; design and construction; detector; experience; foot; image processing; instrument; interest; lymph nodes; optical imaging; phase change; programs; software development; tomography

Task Specific Project #2: FDPM Surgical Instrument for intraoperative guidance The goal of this Specific Task Project is to adapt our FDPM instrument for use in the surgical suite to locate and identify cancer positive LNs delineated by NIR dyes conjugated to targeting moieties as described in the primary project. In year three, the first instrument will be developed and delivered for use at the MEDVAMC; the second will be assembled and delivered for use at BTGH in the early part of year four. This instrument will be designed for rapidly acquired fluorescent amplitude images rather than tomography. When the phase difference between gain modulation of the intensifier and the laser diode is kept constant, a stead-state image is captured that is sensitive to the magnitude of the phase delay. If we introduce a zero and 90 degree phase change between the modulated excitation light and the detector, two different stead-state images are collected. The difference between these two images results in the fluorescent amplitude image is obtained without the confounding effect of the ambient DC light levels. This approach was employed under light levels of fluoroscopy with our work with Mallinckrodt Medical and the Lovelace Research Institute in the mid 1990s to image reactive lymph nodes in canines [90].

任务特定项目＃2：FDPM术中指导的手术工具 这个特定任务项目的目的是调整我们的FDPM工具以供手术套件找到 并确定NIR染料所描述的癌症阳性LN，如在靶向部分的靶向部分 主要项目。在第三年级，将开发和交付第一个乐器，以便在MEDVAMC使用； 第二个将在第四年初在BTGH组装并供使用。该乐器将 设计用于快速获得的荧光振幅图像，而不是断层扫描。阶段时 增强器的增益调制和激光二极管的差异保持恒定，稳定状态图像 被捕获对相延迟的大小敏感。如果我们引入零和90度阶段 调制激发光和检测器之间的变化，收集了两个不同的稳态图像。 这两个图像之间的差异导致 获得荧光振幅图像，而没有混淆 环境直流光水平的影响。这种方法是 在我们的工作中使用的透视镜检查 Mallinckrodt Medical和Lovelace Research Institute 1990年代中期以犬类中的反应性淋巴结图像[90]。