2012 Intrinsically Disordered Proteins Gordon Research Conference

2012 年本质无序蛋白质戈登研究会议

• 批准号: 8399401
• 负责人: ROHIT V PAPPU
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399401
• 关键词: Alzheimer' s Disease; Amino Acid Sequence; Attention; Award; Behavior; Belgium; Binding; Biochemical; Biological Process; Biology; Cataloging; Catalogs; Cell physiology; Cells; Collaborations; Complex; Computer Simulation; Cues; Data; Development; Dimensions; Disease; Drug Delivery Systems; Emerging Technologies; Fostering; Funding; Future; Goals; Heterogeneity; Homeostasis; Huntington Disease; In Vitro; Knowledge; Lead; Light; Location; Malignant Neoplasms; Methods; Mind; Minority Groups; Modeling; Molecular; Molecular Biology; Natural regeneration; Nature; Nerve Degeneration; Neurodegenerative Disorders; Nucleic Acids; Parkinson Disease; Participant; Peptide Sequence Determination; Phase; Play; Post-Translational Protein Processing; Postdoctoral Fellow; Process; Proteins; Quality Control; Research; Resort; Role; Science; Scientist; Series; Shapes; Signal Pathway; Signal Transduction; Signaling Protein; Snow; Structure-Activity Relationship; Students; System; Therapeutic Intervention; Time; Tissues; Transcriptional Regulation; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Ursidae Family; Vermont; Washington; Woman; Work; base; coping; design; graduate student; human disease; in vivo; insight; meetings; molecular recognition; new technology; new therapeutic target; novel; posters; programs; protein function; protein structure; protein transport; response; self assembly; spatiotemporal; symposium; theories; three dimensional structure; tool; trafficking

DESCRIPTION (provided by applicant): The 2nd Intrinsically Disordered Proteins (IDP) Gordon Research Conference will be held between July 08 and July 13, 2012, at the Mt. Snow Resort in West Dover, Vermont, USA. The Co-chairs for this conference are Dr. Rohit Pappu from Washington University in St. Louis, USA and Dr. Peter Tompa from Vrije Universiteit Brussel in Belgium. The long-held view has been that proteins have to form ordered three-dimensional structures in order to achieve their proper biological functions. This view has been challenged by the observation that roughly 30% of eukaryotic proteins fail to fold autonomously and their inability to fold is required for function. Such proteins, referred to as intrinsically disordered proteins or IDPs are implicated in a wide variety of functions that include fundamental processes such as transcriptional regulation, signal transduction, protein trafficking, protein homeostasis and quality control. Most biological functions are based on molecular recognition and complex networks are organized around a series of inter-related protein-protein and protein-nucleic acid interfaces. In the traditional view, molecular recognition is achieved through a combination of shape complementarity and specific interactions between a protein and its binding partner. Small-scale changes in shape are envisaged to achieve highly specific complexes. IDPs add an entirely new dimension to molecular recognition because it requires large- scale conformational changes to achieve binding. It also raises the challenging question of how specific recognition can be achieved in the absence of precise pre-organized shape complementarity. And yet, IDPs are ubiquitous in nature and form the basis for a range of complex biological functions including novel functions that go beyond molecular recognition whereby IDPs play roles in self-assembly and as entropic machines. The growing recognition of the role of IDPs in complex biological functions makes this an opportune time to bring together scientists in the field to identify the important questions, take stock of current progress, and chart the course for rapid and meaningful progress in the study of conformational heterogeneity and its role in protein function. A point of special relevance to NIH is that IDPs are overrepresented in association with numerous human diseases such as neurodegenerative diseases and cancer. Viewed in this light of this, the 2012 Gordon Conference on Intrinsically Disordered Proteins (IDPs) is shaping up to be an exciting and important meeting. The conference will provide a timely opportunity to bring experts and young scientists together to take stock of progress and chart the course for future developments with regards to the role of IDPs in basic biology and identifying novel therapeutic targets in IDP-associated diseases such as neurodegenerative disorders and cancers. The program features an outstanding and diverse group of scientists at the forefront of research in the IDP field. The meeting will be organized around seven thematic sessions focusing on Transcriptional regulation, Signaling pathways & modules, IDP phase behavior and Molecular recognition, Emerging Technologies for Studying IDPs, IDP quality control and homeostasis, Regulated self-assembly and mis- assembly of IDPs, and IDP targeting, trafficking and processing. The meeting will be bookended by two keynote sessions. The tools traditionally used for studying protein structures and structure-function relationships are generally unsuitable in studies of IDPs because of their underlying conformational heterogeneity. Novel advances are needed and the IDP Gordon Conference will showcase the development of state-of-the art biophysical methods, advances in theory and computation, and the synergy with novel tools from molecular biology for studying IDPs and developing a quantitative perspective on their functions in vivo. Poster sessions will be organized to encourage active participation from young scientists. The organizers have arranged for postdocs and graduate students to compete for up to seven awards based on their poster presentations, which will be judged by leaders in the IDP field. The new location for this conference is scenic, convenient, and promises to be an excellent setting for numerous information discussions during the conference. A major goal associated with this request for R13 funding is to provide support for young scientists to participate in the Gordon Research Conference. In choosing the recipients for support through NIH funds, the organizers will pay special attention to the need for drawing young scientists who are women and belong to under-represented minority groups.

描述（由申请人提供）：2012年7月8日至7月13日，在2012年7月8日至7月13日在美国佛蒙特州西多佛市的Snow Resort举行了第二个本质上无序的蛋白质（IDP）戈登研究会议。本次会议的联合主席是美国圣路易斯华盛顿大学的Rohit Pappu博士和比利时的Vrije Universiteit Brussel的Peter Tompa博士。 长期以来的观点是，蛋白质必须形成有序的三维结构，以实现其适当的生物学功能。观察到，这种观点的挑战是，大约30％的真核蛋白无法自主折叠，并且其功能无力折叠。这种蛋白质（称为本质上无序的蛋白质或IDP）与多种功能有关，其中包括基本过程，例如转录调控，信号转导，蛋白质运输，蛋白质稳态和质量控制。 大多数生物学功能基于分子识别，复杂的网络围绕一系列相关的蛋白质 - 蛋白质和蛋白核酸界面进行组织。从传统的角度来看，分子识别 通过形状互补性和蛋白质及其结合伴侣之间的特定相互作用的结合来实现。设想增加形状的小规模变化，以实现高度特异性的复合物。 IDP为分子识别增加了一个全新的维度，因为它需要大规模构象变化才能实现结合。这也提出了一个充满挑战的问题，即在没有精确的预构造形状互补性的情况下如何实现特定认识。然而，IDP本质上是无处不在的，并构成了一系列复杂的生物学功能的基础，包括新功能超出了分子识别，而IDP在自组装和作为熵机中起着作用。 对IDP在复杂生物学功能中的作用的认识日益认识到这是将科学家汇集在一起​​，以确定重要问题，库存当前进步，并为构象异质性研究及其在蛋白质功能中的作用而快速而有意义的进步绘制课程。与NIH的特殊相关点是，IDP与许多人类疾病（例如神经退行性疾病和癌症）相关。从这种情况下，2012年的戈登固有蛋白质（IDP）会议正在塑造是一个令人兴奋且重要的会议。 该会议将提供及时的机会，将专家和年轻科学家聚集在一起，以盘点进步，并在IDP在基本生物学中的作用以及确定与IDP相关疾病（例如神经退行性疾病和癌症）中的新型治疗靶标的未来发展的课程。该计划以IDP领域研究的最前沿的一群杰出而多样的科学家组为特色。这次会议将在七个主题会议上进行组织，重点是转录调节，信号通路和模块，IDP相行为和分子识别，用于研究IDP，IDP质量控制和体内稳定的新兴技术，规范的自组装和误差IDP和IDP的误差以及IDP靶向，贩运，贩运和处理。会议将由两个主题会议预订。传统上用于研究蛋白质结构和结构功能关系的工具在IDP的研究中通常不合适，因为它们的潜在构象异质性。需要新的进步，IDP戈登会议将展示最先进的生物物理方法，理论和计算的进步，以及从分子生物学的新型工具的协同作用，用于研究IDP并对其体内功能的定量观点。 海报会议将被组织，以鼓励年轻科学家的积极参与。组织者已经安排了博士后和研究生，根据其海报演示，最高七个奖项，这将由IDP领域的领导者判断。这次会议的新地点风景优美，方便，并且有望成为会议期间众多信息讨论的绝佳环境。与此要求R13资金有关的主要目标是为年轻科学家参加参加戈登研究会议的支持。在通过NIH资金选择接收者的支持者时，组织者将特别注意吸引妇女的年轻科学家并属于代表性不足的少数群体。