2011 Proteins

2011 蛋白质

• 批准号: 8128057
• 负责人: JAMES U BOWIE
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128057
• 关键词: Amyloid; Biogenesis; Biological; Biological Process; Biology; Categories; Cells; Chemicals; Communities; Complex; Computer Simulation; Crystallography; Disease; Drug usage; Ethnic Origin; Fertilization; Fostering; Functional disorder; Funding Applicant; Future; Gender; Gene Expression; Health; Human; Image; Individual; Lead; Medical; Membrane Proteins; Metabolism; Molecular Structure; Motion; Mutation; New Hampshire; Participant; Pathway interactions; Physics; Property; Proteins; Research; Schools; Science; Scientist; Signal Pathway; Structure; Surveys; Techniques; Therapeutic; Time; Uncertainty; Underrepresented Minority; Woman; Wrestling; age group; amyloidogenesis; career; combat; design; drug discovery; engineering design; interest; meetings; posters; programs; protein aggregation; protein folding; single molecule; symposium; theories; tool; trend

DESCRIPTION (provided by applicant): Funds are requested to support the 2011 Proteins Gordon Research Conference to be held at the Holderness School in New Hampshire, June 19-24. This is a long-standing and usually oversubscribed meeting that serves the scientific community and is focused on the fundamental properties of protein molecules, including their structure, folding, dynamics, stability, and interactions. In the Gordon Conference tradition, we will meet in a small setting with plenty of time for discussion and casual interactions that lead to new ideas and research directions. The prior 2009 meeting was oversubscribed and survey results placed it in the "high performing" category of Gordon Conferences. The meeting is being organized by chairs James Bowie (UCLA) and Patricia Clarke (Notre Dame) and vice-chairs Bertrand Garcia-Moreno (Hopkins) and Amy Keating (MIT), who have all collaborated to put together the initial program. We believe the program reflects the diversity of protein science in terms of topics (theory, design, folding, membrane proteins, cellular assemblies), gender (half the organizers and nearly 40% of the speakers are women), region (speakers from all regions of the US and three non US speakers), age group (20% early career speakers) and ethnicity (an organizer and at least one speaker from underrepresented minorities). We have included space for a large number (11) talks that will be selected from posters which will certainly allow us to increase the fraction of early career speakers and we will further consciously seek to bolster the diversity of speakers by this mechanism. The meeting will be bookended with keynote talks by David Agard (UCSF), a pioneer in the study of macromolecular structure and Susan Lindquist (MIT), a leader in the field of amyloids. We plan regular sessions covering the following topics: Large Cellular Assemblies, Protein Folding, Design and Engineering, Protein Aggregation/Amyloidogenesis, Protein Biogenesis, Dynamics and Synthetic/Chemical Biology. We have little doubt that the conference will be of interest to a wide swath of the protein scientists and is likely expose all the participants to topics and ideas they do not regularly wrestle with. PUBLIC HEALTH RELEVANCE: including health-related significance Proteins are central actors in most biological processes, including those relevant to human health. Proteins are involved in such important biological processes as signaling pathways, metabolism, and gene expression that go awry in disease states. Protein mutation, misfolding or dysfunction is directly implicated in many diseases. Thus, proteins are the usual targets of drugs use to combat disease. The 2011 Proteins GRC will explore recent advances and future trends in understanding the structure, stability, motions, and interactions of protein molecules and how these fundamental properties impact function in biological and medical contexts. New pathways to therapeutic tools will also be a major focus.

描述（由申请人提供）：请求资金支持将于 6 月 19 日至 24 日在新罕布什尔州霍尔德内斯学校举行的 2011 年蛋白质戈登研究会议。这是一个长期存在且通常超额认购的会议，为科学界服务，重点关注蛋白质分子的基本特性，包括其结构、折叠、动力学、稳定性和相互作用。按照戈登会议的传统，我们将在一个小环境中会面，有充足的时间进行讨论和随意互动，从而产生新的想法和研究方向。 2009 年之前的会议获得了超额认购，调查结果将其归为戈登会议的“高绩效”类别。该会议由主席 James Bowie（加州大学洛杉矶分校）和 Patricia Clarke（圣母大学）以及副主席 Bertrand Garcia-Moreno（霍普金斯大学）和 Amy Keating（麻省理工学院）组织，他们共同制定了最初的计划。我们相信该计划反映了蛋白质科学在主题（理论、设计、折叠、膜蛋白、细胞组装）、性别（一半的组织者和近 40% 的演讲者是女性）、地区（来自所有地区的演讲者）方面的多样性。的美国人和三名非美国发言者）、年龄组（20％的早期职业发言者）和种族（一名组织者和至少一名来自代表性不足的少数族裔的发言者）。我们为大量（11）个演讲提供了空间，这些演讲将从海报中选出，这肯定会让我们增加早期职业演讲者的比例，并且我们将进一步有意识地寻求通过这种机制增强演讲者的多样性。大分子结构研究的先驱 David Agard（加州大学旧金山分校）和淀粉样蛋白领域的领导者 Susan Lindquist（麻省理工学院）将在会议结束时发表主题演讲。我们计划定期举办会议，涵盖以下主题：大细胞组装、蛋白质折叠、设计和工程、蛋白质聚集/淀粉样蛋白生成、蛋白质生物发生、动力学和合成/化学生物学。我们毫不怀疑，这次会议将引起广大蛋白质科学家的兴趣，并可能让所有参与者接触到他们不经常讨论的主题和想法。 公共卫生相关性：包括与健康相关的意义 蛋白质是大多数生物过程的核心参与者，包括与人类健康相关的生物过程。蛋白质参与信号通路、新陈代谢和基因表达等重要的生物过程，这些过程在疾病状态下会出错。蛋白质突变、错误折叠或功能障碍与许多疾病直接相关。因此，蛋白质是用于对抗疾病的药物的通常目标。 2011 年蛋白质 GRC 将探讨了解蛋白质分子的结构、稳定性、运动和相互作用以及这些基本特性如何影响生物和医学环境中的功能的最新进展和未来趋势。治疗工具的新途径也将成为主要焦点。